التفاصيل البيبلوغرافية
| العنوان: |
Interaction between the p75 neurotrophin receptor and a novel adaptor protein |
| المؤلفون: |
Lee, Seung-Pyo, Lee, Yun-Hee, Yu, Ji-Hee, Cho, Jung-Sun, Park, Han-Jeong, Paik, Ki-Suk, Chang, Mi-Sook |
| المساهمون: |
이승표, 이연희, 유지혜, 조정순, 박한정, 박기숙, 장미숙 |
| بيانات النشر: |
Korean Acadamy of Oral Biology |
| سنة النشر: |
2008 |
| المجموعة: |
Seoul National University: S-Space |
| مصطلحات موضوعية: |
neurotrophins, p75 neurotrophin receptor, neuron, signal transduction, adaptor protein |
| الوصف: |
The neurotrophin plays an important role in the development, differentiation and survival of the nervous system in vertebrates. It exerts its cellular effects through two different receptors, the Trk receptor tyrosine kinase neurotrophin receptor and the p75 neurotrophin receptor, a member of the tumor necrosis factor receptor superfamily. Trk and p75 neurotrophin receptors utilize specific target proteins to transmit signals into the cell. An ankyrin-rich membrane spanning protein (ARMS) was identified as a new p75 interacting protein and serves as a novel downstream target of p75 neurotrophin receptor. We sought to delineate the interaction between p75 and ARMS by deletion constructs of p75 and green fluorescent protein (GFP)-tagged ARMS. We examined the interaction between these two proteins after overexpressing them in HEK-293 cells. Using both Western blot analysis and immunocytochemistry followed by confocal laser scanning microscopy, we found out that the intracellular domain of the p75 neurotrophin receptor was important for the interaction with ARMS. The results from this study suggest that ARMS may play an important role for mediating the signals from p75 neurotrophin receptor into the cell. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
Korean |
| تدمد: |
1226-7155 |
| العلاقة: |
International Journal of Oral Biology. 33:71-76; http://hdl.handle.net/10371/69796Test |
| الإتاحة: |
http://hdl.handle.net/10371/69796Test |
| رقم الانضمام: |
edsbas.1D635393 |
| قاعدة البيانات: |
BASE |
