المؤلفون: Marta Rodrigues, Marta Grilo, Maria João Baptista

المصدر: Journal of Pediatric and Neonatal Individualized Medicine, Vol 12, Iss 2, Pp e120206-e120206 (2023)

مصطلحات موضوعية: pediatric, traumatic brain injury, hyperosmolar therapy, mannitol, hypertonic saline, intracranial pressure, Medicine, Pediatrics, RJ1-570

الوصف: Background: Traumatic brain injury (TBI) is a prominent reason for morbidity and mortality in children. The use of hyperosmolar therapy to manage increased intracranial pressure (ICP) is portrayed in pediatric guidelines; however, there still remains some debate regarding which option to select. The aim of this systematic review was to assess which hyperosmolar therapy – mannitol or hypertonic saline (HTS) – is more effective in terms of lowering ICP and having better outcomes in treating children with TBI. Methods: A literature search was conducted using MEDLINE (through PubMed), Scopus, and Web of Science. This review included 6 retrospective and prospective studies comparing the use of mannitol and HTS in pediatric patients with TBI. Results: HTS was the most frequently described hyperosmolar agent, obtaining better results in managing ICP, cerebral perfusion pressure and osmolarity. It also showed to be effective in refractory intracranial hypertension, in situations where mannitol fails to lower ICP. Mannitol was less studied but demonstrated a higher incidence of mortality than HTS. There were several studies that did not report monitoring outcomes associated with serum osmolarity, despite the use of hyperosmolar therapies. Discrepancies were noticed between the studies in the overall study design in addition to reported monitoring parameters and length of stay. Conclusions: HTS seems to be safe and efficient in the treatment of severe TBI in children. The reduced existing studies regarding the use of mannitol do not permit a strong decision to be made concerning its practice. For the time being, the choice of hyperosmolar therapy in this context must be individualized and based on clinical practice and experience, not disregarding the latest guidelines that recommend the use of HTS.

وصف الملف: electronic resource

العلاقة: https://jpnim.com/index.php/jpnim/article/view/1393Test; https://doaj.org/toc/2281-0692Test

الوصول الحر: https://doaj.org/article/8a736d4538d044679c44de04255da0fcTest

المؤلفون: Georgios N. Katsaras, Dimitra Gialamprinou, Ilias Chatziioannidis, Paraskevi Karagianni, Georgios Mitsiakos

المصدر: Journal of Pediatric and Neonatal Individualized Medicine, Vol 11, Iss 2, Pp e110238-e110238 (2022)

مصطلحات موضوعية: f13a1 val34leu, polymorphism, recurrent pregnancy loss, prolonged umbilical cord bleeding, intracranial hemorrhage, Medicine, Pediatrics, RJ1-570

الوصف: Coagulation factor XIII deficiency (FXIIID) is a rare inherited autosomal recessive bleeding disorder. FXIIID is the only coagulation factor deficiency that has been associated with pregnancy loss. Regarding neonates, prolonged umbilical cord bleeding and intracranial hemorrhage, a life-threatening condition in the neonatal period, have been reported in cases with inherited FXIIID. In this report, we present a case of a newborn of a homozygous F13A1 Val34Leu variant mother, while reviewing the current literature.

وصف الملف: electronic resource

العلاقة: https://jpnim.com/index.php/jpnim/article/view/1174Test; https://doaj.org/toc/2281-0692Test

الوصول الحر: https://doaj.org/article/fcfac20db06043389bee459a4fdab063Test

المؤلفون: Labeyrie PE, Goulay R, Martinez de Lizarrondo S, Hébert M, Gauberti M, Maubert E, Delaunay B, Gory B, Signorelli F, Turjman F, Touzé E, Courthéoux P, Vivien D, Orset C.

المساهمون: Labeyrie, Pe, Goulay, R, Martinez de Lizarrondo, S, Hébert, M, Gauberti, M, Maubert, E, Delaunay, B, Gory, B, Signorelli, F, Turjman, F, Touzé, E, Courthéoux, P, Vivien, D, Orset, C.

مصطلحات موضوعية: animals, intracranial aneurysm, mice, physiopathology, tissue plasminogen activator

الوصف: Background and Purpose—Although the mechanisms that contribute to intracranial aneurysm (IA) formation and rupture are not totally elucidated, inflammation and matrix remodeling are incriminated. Because tPA (tissue-type plasminogen activator) controls both inflammatory and matrix remodeling processes, we hypothesized that tPA could be involved in the pathophysiology of IA. Methods—Immunofluorescence analyses of tPA and its main substrate within the aneurysmal wall of murine and human samples were performed. We then compared the formation and rupture of IAs in wild-type, tPA-deficient and type 1 plasminogen activator inhibitor–deficient mice subjected to a model of elastase-induced IA. The specific contribution of vascular versus global tPA was investigated by performing hepatic hydrodynamic transfection of a cDNA encoding for tPA in tPA-deficient mice. The formation and rupture of IAs were monitored by magnetic resonance imaging tracking for 28 days. Results—Immunofluorescence revealed increased expression of tPA within the aneurysmal wall. The number of aneurysms and their symptomatic ruptures were significantly lower in tPA-deficient than in wild-type mice. Conversely, they were higher in plasminogen activator inhibitor–deficient mice. The wild-type phenotype could be restored in tPA-deficient mice by selectively increasing circulating levels of tPA via hepatic hydrodynamic transfection of a cDNA encoding for tPA. Conclusions—Altogether, this preclinical study demonstrates that the tPA present in the blood stream is a key player of the formation of IAs. Thus, tPA should be considered as a possible new target for the prevention of IAs formation and rupture.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28754830; info:eu-repo/semantics/altIdentifier/wos/WOS:000408438000059; journal:STROKE; http://hdl.handle.net/11586/218701Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85030434751

الإتاحة: http://hdl.handle.net/11586/218701Test

المؤلفون: Econimo, Laura, Zeni, Letizia, Cortinovis, Roberta, Alberici, Federico, Izzi, Claudia, Scolari, Francesco

المساهمون: Econimo, Laura, Zeni, Letizia, Cortinovis, Roberta, Alberici, Federico, Izzi, Claudia, Scolari, Francesco

مصطلحات موضوعية: ADPKD, intracranial aneurysm, risk of rupture, screening, treatment, Follow-Up Studie, Human, Kidney, Kidney Failure, Chronic, Polycystic Kidney, Autosomal Dominant

الوصف: Autosomal dominant polycystic kidney disease (ADPKD) is the most frequent hereditary nephropathy and is the fourth most common cause for end-stage renal disease in Europe. ADPKD is a systemic disease; besides the typical renal involvement, characterized by progressive cyst expansion leading to massive enlargement and distortion of the kidney architecture and, ultimately, to end-stage renal disease, multiple extrarenal manifestations can be observed included cysts in other organs, diverticulosis, cardiac valvulopathies, abdominal and inguinal hernias, vascular anomalies. The rupture of an intracranial aneurysm is one of the most serious complications in ADPKD patients. Aim of this review is to provide useful indications for the clinician to define the risk of intracranial aneurysms in ADPKD population, to identify screening criteria (which patients to screen, how often and with which diagnostic methods), to estimate the risk of rupture of intracranial aneurysms, which may require intervention.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/34713642; volume:38; issue:5; journal:GIORNALE ITALIANO DI NEFROLOGIA; http://hdl.handle.net/11379/554239Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85121191412

الإتاحة: http://hdl.handle.net/11379/554239Test

العنوان البديل: The impact of hygienic care on intracranial pressure in patients with severe head injury: a review of the literature. (English)

المؤلفون: CAPELLINI, VERA, TERZONI, STEFANO, DESTREBECQ, ANNE, LONGOBARDI, ANTONIO

المصدر: SCENARIO: Official Italian Journal of ANIARTI; 2015, Vol. 32 Issue 2, p31-35, 5p

مصطلحات موضوعية: BRAIN injuries, HYGIENE, INTENSIVE care nursing, INTRACRANIAL pressure, NEUROLOGICAL nursing, NURSING assessment

المؤلفون: Fabrizio Lazzara, Federica Giorda, Katia Varello, Maria Teresa Mandara, Simona Zoppi, Mariella Goria, Milena Monnier, Tiziana Avanzato, Cristina Casalone and Barbara Iulini

المساهمون: Lazzara, Fabrizio, Giorda, Federica, Varello, Katia, Mandara, Maria Teresa, Zoppi, Simona, Goria, Mariella, Monnier, Milena, Avanzato, Tiziana, Casalone and Barbara Iulini, Cristina

مصطلحات موضوعية: Intracranial, Ovis aries, Papillomavirus, Squamous cell carcinoma

الوصف: Squamous cell carcinoma (SCC) is a malignant mucoepithelial tumor that affects pets and farm animals. Common sites are dorsal areas and/or areas of poor skin pigmentation exposed to mutagenic ultraviolet (UV) radiation. Novel ovine papillomavirus (OaPV3) was recently described in SCC lesions in Sardinia breed ovines. In 2017, a 7‐year‐old half‐breed aries was presented with symptoms compatible with a vestibular syndrome. The animal was euthanized 1 month after the onset of clinical signs due to a lack of response to treatment and poor prognosis. A complete postmortem examination was performed. Necropsy revealed only a loss of incisors, associated with alveolar necrotic osteomyelitis, and left unilateral purulent nasal discharge. No other thoracic or abdominal lesions were observed. Opening of the skull revealed a cauliflower‐like space‐occupying mass. Histological examination showed trabecules and islands of squamous, neoplastic epithelial cells with the formation of concentric keratin layers. This raised the suspicion of SCC, which was confirmed with cytokeratin‐positive immunostaining. Simplex PCR on the frozen tissue mass was negative for OaPV1, OaPV2, and OaPV3. This case report suggests that SCC, although rare, should be included in the differential diagnosis of cases of vestibular disorder. Fabrizio Lazzara1*, Federica Giorda1, Katia Varello1, Maria Teresa Mandara2, Simona Zoppi1, Mariella Goria1, Milena Monnier1, Tiziana Avanzato1, Cristina Casalone1 and Barbara Iulini1Intracranial squamous cell carcinoma in an Ovis ariesVeterinaria Italiana 2020, 56 (2), 141‐144. doi:10.12834/VetIt.1911.10405.2Accepted: 31.01.2020 | Available on line: 31.12.2020

وصف الملف: STAMPA

العلاقة: volume:56; issue:2; firstpage:141; lastpage:144; numberofpages:4; journal:VETERINARIA ITALIANA; http://hdl.handle.net/11391/1490881Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85099201505

الإتاحة: https://doi.org/10.12834/VetIt.1911.10405.2Test
http://hdl.handle.net/11391/1490881Test

المؤلفون: Luca Masotti, Alessandro Pampana, Paolo Pennati, Giancarlo Landini

المصدر: Italian Journal of Medicine, Vol 5, Iss 1, Pp 34-44 (2013)

مصطلحات موضوعية: Intracranial haemorrhage, Oral anticoagulant therapy, Prothrombin complex concentrate, Fresh frozen plasma, Recombinant activated factor VII, Medicine

الوصف: Introduction: Intracranial haemorrhage (ICH) is associated with high mortality and morbidity, and for this reason it is the most feared complication of oral anticoagulant therapy (OAT). Recommendations are available for the immediate reversal of OAT, but these measures are not always used uniformly and rapidly. The aim of this study was to critically review the treatment of spontaneous OAT-related ICH in our hospital. Materials and methods: We retrospectively analyzed the medical records of patients admitted to our ward between January 2006 and January 2010 for spontaneous OAT-related ICH. Results: In the analyzed period, 15 patients were hospitalized for OAT-related ICH (supratentorial in 66.5%, infratentorial in 20%, acute subdural hematoma in 13.5%). In 66.5% of the patients, the INR on arrival was within the therapeutic range. In 60% of the cases, the Glasgow Coma Scale (GCS) on arrival was > 8/15. Three-factor prothrombin complex concentrate (PCC) was administered in 80% of the cases, and 30% of patients received fresh frozen plasma (FFP) and recombinant activated factor VII (FVIIra). One patient received PCC plus PFC, and another received PCC with FVIIra. FFP alone was used in 13.5% of the patients. All of the patients received intravenously administered vitamin K1. Treatment was started in the Emergency Room in 33.5% of the cases; in the other 66.5% it began on our ward. In 66.5% of the patients, the treatment was effective in reversing OATwithin 8 hours. In 2 cases, the hematoma was surgically evacuated, and the patients survived. Total mortality for OAT-related ICH was 46.5% (32.9% in non-OAT-related ICH). In 71.5% of the patients with OAT-related haemorrhages, death occurred within 48 hours of arrival. Sixty percent of the patients with ICH > 60 cm3 (20% in patients with ICH < 60 cm3) and 100% of those with GCS < 7/15 died. For survivors, the median modified Rankin Scale at discharge was 3. All survivors were still alive at 3 months after discharge. Conclusions: Our study shows that in ICH ...

العلاقة: http://www.italjmed.org/index.php/ijm/article/view/147Test; https://doaj.org/toc/1877-9344Test; https://doaj.org/toc/1877-9352Test; https://doaj.org/article/8cacb6860b0247d4b45a4a75f293a394Test

الإتاحة: https://doi.org/10.4081/itjm.2011.34Test
https://doaj.org/article/8cacb6860b0247d4b45a4a75f293a394Test

المؤلفون: Giuseppe, Tarantini, Gianpiero, D'Amico, Claudio, Baracchini, Andrea, Berni, Sergio, Berti, Massimo, Chessa, Giovanni, Esposito, Achille, Gaspardone, Alberto, Menozzi, Francesco, Meucci, Giuseppe, Musumeci, Eustaquio, Onorato, Stefano, Rigattieri, Francesco, Saia, Pino, Santoro, Paolo, Scacciatella, Daniela, Trabattoni, Chiara, Fraccaro, Cristian, Pristipino

مصطلحات موضوعية: Italy, Risk Factors, Thromboembolism, Decision Making, Cardiology, Foramen Ovale, Patent, Humans, Cryptogenic stroke, Patent foramen ovale, Intracranial Thrombosis

الوصف: Patent foramen ovale (PFO) is implicated in the pathogenesis of different clinical syndromes in which it plays variable roles. In 2017 and 2018, four randomized clinical trials were published, allowing for the clarification of certain issues pertaining to cryptogenic stroke. Recently, eight European scientific societies collaborated to the writing of an interdisciplinary international position paper on PFO and cryptogenic stroke, based upon best available evidence, with the aim of defining the principles needed to guide decision making. Nonetheless, a tailored approach is not suitably addressed by standard position documents, considering that decisions about optimal management of PFO patients with left circulation thromboembolism are often challenging, mostly due to comorbidities and complex clinical scenarios.A panel of Italian cardiology experts gathered under the auspices of the Italian Society of Interventional Cardiology (SICI-GISE) for comprehensive discussion and consensus development, with the aim of providing practical recommendations, for both clinical and interventional cardiologists, regarding optimal management of PFO in patients with cerebral or systemic thromboembolism. In this position paper, various clinical scenarios in patients with and without high-risk PFO features are presented and discussed, including PFO patients with associated conditions (e.g. hypercoagulable states, deep vein thrombosis/pulmonary embolism, short runs of atrial fibrillation), and special subsets (e.g. patients with risk factors for atrial fibrillation, patients aged ≥65 years, patients who refused percutaneous PFO closure), with the Panel's recommendations being provided for each scenario.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::c3ae5ee7ef18f1473796449f188a8babTest
http://hdl.handle.net/11577/3351930Test

المؤلفون: Luca, Montecchiani, Jacopo, Alfonsi, Mariano, Cefarelli, Paolo, Berretta, Filippo, Capestro, Marco, Di Eusanio

المساهمون: Montecchiani L., Alfonsi J., Cefarelli M., Berretta P., Capestro F., Di Eusanio M.

مصطلحات موضوعية: Aged, 80 and over, Male, Extracorporeal Circulation, Aortic Diseases, Calcinosis, Heart Valves, Embolic Protection Devices, Treatment Outcome, Intracranial Embolism, Italy, Aortic Valve, Preoperative Care, Humans, Mitral Valve, Female, Cardiac Surgical Procedures, Intraoperative Complications, Tomography, X-Ray Computed, transcatheter cerebral protection systems, Aged

الوصف: BACKGROUND: Neurological events after cardiac surgery or transcatheter aortic valve implantation (TAVI) have a dramatic effect on patients' prognosis. Recent development of transcatheter cerebral protection systems aims to reduce their incidence, even if their use is currently limited to TAVI. Here we report our initial experience with transcatheter cerebral protection devices used in patients at high brain embolic risk undergoing cardiac surgery. METHODS: Between December 2018 and March 2020, at the Cardiac Surgery Unit of Lancisi Cardiovascular Center in Ancona, Italy, 9 patients (mean age 77 years; median EuroSCORE II: 2.2%) underwent cardiac surgery using a transcatheter cerebral protection system (Sentinel, Claret Medical, Santa Rosa, CA, USA). In all cases, a preoperative computed tomography scan highlighted the presence of severely calcified ascending aorta. RESULTS: The brain protection system was successfully implanted in all patients. Total time for device implantation and removal was less than 10 min in all cases. Four patients underwent aortic valve replacement, 2 mitral surgery, whereas 3 received combined valve surgery. Calcified debris were found within filters in 100% of patients. Postoperatively, there were neither neurological events nor major complications. CONCLUSIONS: In our experience, transferring transcatheter brain protection techniques and technologies to cardiac surgery allowed us (with excellent results) to avoid palliative percutaneous or medical management in patients with severe aortic calcifications. Waiting for more solid evidence, we believe that our example supports the concept of hybrid surgery as a therapeutic approach capable of extending traditional surgical indications with improved patients' outcomes.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::ce3d9fe26b2015f7b5a5159d0c577d53Test
http://hdl.handle.net/11585/794975Test

المؤلفون: Rezoagli, E, Ageno, W, Masotti, L, Godoy, D, Di Napoli, M, Paciaroni, M, Rabinstein A.

المساهمون: Rezoagli, E, Ageno, W, Masotti, L, Godoy, D, Di Napoli, M, Paciaroni, M, Rabinstein, A

مصطلحات موضوعية: Intracranial bleeding, Deep vein thrombosi, Pulmonary embolism, Prophylaxi, Low molecular weigh heparin, Unfractionated heparin, Physical methods, MED/41 - ANESTESIOLOGIA

الوصف: Spontaneous intracerebral haemorrhage (SIH) represents a severe clinical event that is associated with high rates of mortality and morbidity. Only a minority of SIH patients receive surgical treatment, whereas the majority are treated conservatively. Venous thromboembolism (VTE) is one of the most common complications in SIH patients and a potential cause of death. Because of the lack of adequate evidences from the literature, the risk to benefit ratio of pharmacologic prophylaxis of VTE, represented on the one hand by hematoma enlargement and/or rebleeding and on the other hand by an expected reduction of the risk of VTE, remains controversial. Mechanical prophylaxis is a potentially safer alternative, but the efficacy of this approach is uncertain. In the absence of specific clinical guidelines containing clear-cut recommendations, physicians have insufficient tools to assist their therapeutic decisions.

وصف الملف: STAMPA

العلاقة: volume:2; issue:1s; firstpage:109; lastpage:114; numberofpages:6; journal:REVIEWS IN HEALTH CARE; http://hdl.handle.net/10281/287246Test; https://journals.seedmedicalpublishers.com/index.php/rhc/article/view/32/91Test

الإتاحة: http://hdl.handle.net/10281/287246Test
https://journals.seedmedicalpublishers.com/index.php/rhc/article/view/32/91Test