دورية أكاديمية
Lanthanide-doped CaF2 and SrF2 nanoparticles for biomedical applications: in vivo and in vitro experimental studies
| العنوان: | Lanthanide-doped CaF2 and SrF2 nanoparticles for biomedical applications: in vivo and in vitro experimental studies |
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| المؤلفون: | Corinne Portioli, Marco Pedroni, Donatella Benati, Stefano Dusi, Marta Donini, Raffaella Mariotti, Roberta Bonafede, Luigi Perbellini, Marzia Cerpelloni, Adolfo Speghini, Marina Bentivoglio |
| المساهمون: | Portioli, Corinne, Pedroni, Marco, Benati, Donatella, Dusi, Stefano, Donini, Marta, Mariotti, Raffaella, Bonafede, Roberta, Perbellini, Luigi, Cerpelloni, Marzia, Speghini, Adolfo, Bentivoglio, Marina |
| سنة النشر: | 2015 |
| المجموعة: | Università degli Studi di Verona: Catalogo dei Prodotti della Ricerca (IRIS) |
| مصطلحات موضوعية: | Lanthanide ion, Nanoparticle, Cell viability, Biodistribution |
| الوصف: | Among the wide range of nanoparticles (NPs) studied for diagnostic and thera-peutic applications lanthanide-doped nanosystems have raised special interest [1]. Their very small dimension (10 nm) and upconversion emission property have increased the range of their applications from contrast agent probes in bioimaging to drug delivery systems [2,3]. Here, the cytotoxicity of rare earth (Yb and Er)-doped CaF2 and SrF2 NPs has been investigated both in vitro and in vivo. In vitro studies have been conducted in a motoneuron cell line as model of neuronal interaction, and in a line of human dendritic cells which play a key role in the immune response. In the motoneuron cell line, a weak response was observed at early time points while the cell viability showed an increment, except for the highest concentration of lan-thanide-doped NPs. The levels of cytokines released from human dendritic cells were low and dose-dependent. The NP biodistribution was investigated after a sin-gle peripheral administration in mice. Aggregates of NPs were shown, with differ-ent techniques, mostly in peripheral organs (spleen and liver) after one day. A limited penetration of both CaF2 and SrF2 NPs was seen in the brain parenchyma, associated with a mild astrocytic activation. Since the present in vitro findings indicate that lan-thanide-doped NPs are safe, and the in vivo data show that they can enter the brain parenchyma crossing the blood-brain barrier, these NPs may represent promising tools for diagnostic and therapeutical applications Lanthanide-doped CaF2 and SrF2 nanoparticles for biomedical applications: in vivo and in vitro experimental studies |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | STAMPA |
| اللغة: | Italian |
| العلاقة: | volume:120; issue:1 (Supplement); firstpage:185; lastpage:185; numberofpages:1; journal:ITALIAN JOURNAL OF ANATOMY AND EMBRYOLOGY; http://hdl.handle.net/11562/985215Test |
| DOI: | 10.13128/ijae-17080 |
| الإتاحة: | https://doi.org/10.13128/ijae-17080Test http://hdl.handle.net/11562/985215Test |
| رقم الانضمام: | edsbas.D7E92441 |
| قاعدة البيانات: | BASE |
| DOI: | 10.13128/ijae-17080 |
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