دورية أكاديمية
AgRP neurons control structure and function of the medial prefrontal cortex
| العنوان: | AgRP neurons control structure and function of the medial prefrontal cortex |
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| المؤلفون: | Stutz, Bernardo, Waterson, Michael J., Šestan-Peša, Matija, Dietrich, Marcelo O., Škarica, Mario, Sestan, Nenad, Racz, Bence, Magyar, Aletta, Sotonyi, Peter, Liu, Zhong-Wu, Gao, Xiao-Bing, Matyas, Ferenc, Stoiljkovic, Milan, Horvath, Tamas L. |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2022 |
| المجموعة: | MTAK: REAL (Library and Information Centre of the Hungarian Academy of Sciences / Magyar Tudományos Akadémia Könyvtár és Információs Központ) |
| مصطلحات موضوعية: | Q1 Science (General) / természettudomány általában, QP Physiology / élettan |
| الوصف: | Hypothalamic agouti-related peptide and neuropeptide Y-expressing (AgRP) neurons have a critical role in both feeding and non-feeding behaviors of newborn, adolescent, and adult mice, suggesting their broad modulatory impact on brain functions. Here we show that constitutive impairment of AgRP neurons or their peripubertal chemogenetic inhibition resulted in both a numerical and functional reduction of neurons in the medial prefrontal cortex (mPFC) of mice. These changes were accompanied by alteration of oscillatory network activity in mPFC, impaired sensorimotor gating, and altered ambulatory behavior that could be reversed by the administration of clozapine, a non-selective dopamine receptor antagonist. The observed AgRP effects are transduced to mPFC in part via dopaminergic neurons in the ventral tegmental area and may also be conveyed by medial thalamic neurons. Our results unmasked a previously unsuspected role for hypothalamic AgRP neurons in control of neuronal pathways that regulate higher-order brain functions during development and in adulthood. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | text |
| اللغة: | Hungarian |
| العلاقة: | http://real.mtak.hu/149187/1/s41380-022-01691-8.pdfTest; Stutz, Bernardo and Waterson, Michael J. and Šestan-Peša, Matija and Dietrich, Marcelo O. and Škarica, Mario and Sestan, Nenad and Racz, Bence and Magyar, Aletta and Sotonyi, Peter and Liu, Zhong-Wu and Gao, Xiao-Bing and Matyas, Ferenc and Stoiljkovic, Milan and Horvath, Tamas L. (2022) AgRP neurons control structure and function of the medial prefrontal cortex. Molecular Psychiatry, 27. pp. 3951-3960. ISSN 1359-4184 (In Press) |
| DOI: | 10.1038/s41380-022-01691-8 |
| الإتاحة: | https://doi.org/10.1038/s41380-022-01691-8Test http://real.mtak.hu/149187Test/ http://real.mtak.hu/149187/1/s41380-022-01691-8.pdfTest |
| رقم الانضمام: | edsbas.5648F1AA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41380-022-01691-8 |
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