دورية أكاديمية
Dissemination of high-level mupirocin-resistant CC22-MRSA-IV in Saxony
| العنوان: | Dissemination of high-level mupirocin-resistant CC22-MRSA-IV in Saxony |
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| المؤلفون: | Monecke, Stefan, Ruppelt-Lorz, Antje, Müller, Elke, Reissig, Annett, Thürmer, Alexander, Shore, Anna C., Coleman, David C., Ehricht, Ralf, Jatzwauk, Lutz |
| المصدر: | GMS Hygiene and Infection Control, Vol 12, p Doc19 (2017) |
| بيانات النشر: | German Medical Science GMS Publishing House, 2017. |
| سنة النشر: | 2017 |
| المجموعة: | LCC:Medicine LCC:Public aspects of medicine LCC:Microbiology |
| مصطلحات موضوعية: | methicillin-resistant Staphylococcus aureus, MRSA, mupirocin, high-level mupirocin resistance, mupA, “Barnim Epidemic Strain”, Medicine, Public aspects of medicine, RA1-1270, Microbiology, QR1-502 |
| الوصف: | Mupirocin is used for eradicating methicillin-resistant (MRSA) in nasal colonization. A plasmid-borne gene, , is associated with high-level mupirocin resistance. Despite the fact that, among all MRSA from a tertiary care center in the German state of Saxony, the prevalence of , encoding high-level mupirocin resistance, was approximately 1% over a 15-year period from 2000–2015, a sharp increase to nearly 20% was observed in 2016/2017. DNA microarray profiling revealed that this was due to the dissemination of a variant of CC22-MRSA-IV (“Barnim Epidemic Strain” or “UK-EMRSA-15”), which, in addition to , harbors , , , and – in most isolates – (C). In order to prevent therapy failures and a further spread of this strain, the use of mupirocin should be more stringently controlled as well as guided by susceptibility testing. In addition, MRSA decolonization regimens that rely on other substances, such as betaisodona, polyhexanide or octenidine, should be considered. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | German English |
| تدمد: | 2196-5226 |
| العلاقة: | http://www.egms.de/static/en/journals/dgkh/2017-12/dgkh000304.shtmlTest; https://doaj.org/toc/2196-5226Test |
| DOI: | 10.3205/dgkh000304 |
| الوصول الحر: | https://doaj.org/article/9d784aaa3a3246b9a9ff9fde219b59baTest |
| رقم الانضمام: | edsdoj.9d784aaa3a3246b9a9ff9fde219b59ba |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 21965226 |
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| DOI: | 10.3205/dgkh000304 |