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مصطلحات موضوعية: Male, medicine.medical_specialty, Ischemia, In Vitro Techniques, Rats, Sprague-Dawley, chemistry.chemical_compound, Atrial natriuretic peptide, Internal medicine, medicine, Animals, Bile, Biliary Tract, Pyruvates, Glutathione Disulfide, L-Lactate Dehydrogenase, Hepatology, business.industry, Gastroenterology, medicine.disease, Glutathione, Rats, Perfusion, Intracellular signal transduction, Endocrinology, Liver, chemistry, Reperfusion Injury, Lactates, Glutathione transport, Glutathione disulfide, Liver function, business, Reperfusion injury, Atrial Natriuretic Factor, hormones, hormone substitutes, and hormone antagonists, Liver Circulation
الوصف: Background/Aims: Atrial natriuretic peptide (ANP) protects against hypoxia/reoxygenation-induced damage of cultured hepatocytes, thus suggesting a therapeutic potential in the liver. Therefore, the effects of ANP on hepatic ischemia/reperfusion injury after warm ischemia were studied. Methods: Livers of male Sprague-Dawley rats subjected to 60 minutes of warm ischemia at 37°C were perfused in the presence or absence of 200 and 20 nmol/L ANP. Results: Sinusoidal lactate dehydrogenase efflux increased to 2000 ± 264 and 126 ± 50 mU · min−1 · g liver−1 after 1 minute and 60 minutes of reperfusion, but it only increased to 1240 ± 160 and 22 ± 16 mU · min−1 · g liver−1 in the presence of 200 nmol/L ANP during the preischemic and postischemic perfusion period. The postischemic bile flow (0.67 ± 0.18 μL · min−1 · g liver−1) was significantly improved with 200 nmol/L ANP (0.92 ± 0.05) and showed a linear correlation to biliary glutathione excretion. In contrast, 20 nmol/L ANP had no protective effects. Administration of 200 nmol/L ANP during the preischemic perfusion period alone (but not after starting reperfusion) markedly preserved postischemic liver function. Conclusions: Continuous ANP administration or ANP pretreatment alone prevents hepatic ischemia/reperfusion injury, possibly because of influences on intracellular signal transduction processes. The correlation between bile flow and biliary glutathione excretion supports the hypothesis that biliary glutathione transport is one of the osmotic driving forces in postischemic bile formation.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2776af42756c42db6ca84ebc9a15f364Test
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المصدر: Deutsche medizinische Wochenschrift (1946). 89
مصطلحات موضوعية: medicine.medical_specialty, Erythrocytes, Reticulocytes, Iron, Glutathione reductase, Pyruvate Kinase, Jaundice, Glucosephosphate Dehydrogenase, Hemolysis, Diagnosis, Differential, chemistry.chemical_compound, Drug Therapy, Bone Marrow, Cholelithiasis, Internal medicine, Lactate dehydrogenase, Chromium Isotopes, medicine, Humans, Radionuclide Imaging, Hyperbilirubinemia, Radioisotopes, Urobilinogen, L-Lactate Dehydrogenase, business.industry, General Medicine, medicine.disease, medicine.anatomical_structure, Endocrinology, Glutathione Reductase, chemistry, Phosphoglucomutase, Glycine, Ion Exchange Resins, Bone marrow, business, Pyruvate kinase
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02ffba1517ec51ca43d68f91aa542077Test
https://pubmed.ncbi.nlm.nih.gov/14218222Test -
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المؤلفون: Otfrid Butenandt
المصدر: Zeitschrift fur Kinderheilkunde. 111(2)
مصطلحات موضوعية: Adult, Aging, Erythrocytes, Adolescent, L-Lactate Dehydrogenase, business.industry, Infant, Newborn, Infant, Glucosephosphate Dehydrogenase, Catalase, Molecular biology, Glutathione, Enzymes, Phenylhydrazines, Glutathione Reductase, Peroxidases, Child, Preschool, Pediatrics, Perinatology and Child Health, Medicine, Humans, business, Child, Heinz Bodies, Infant, Premature
الوصف: Bei Neugeborenen, Sauglingen, Kindern und Erwachsenen wurden folgende Erythrocytenenzyme untersucht: Glutathionperoxydase, Glutathionreduktase, Glucose-6-Phosphatdehydrogenase, Lactatdehydrogenase und Katalase. Auserdem wurde oxydiertes und reduziertes Glutathion gemessen.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7f41abadd59f88b6aaede64a9ee86c5Test
https://pubmed.ncbi.nlm.nih.gov/5127304Test