كتاب
Challenges in the Medicinal Chemical Optimization of Binding Kinetics
| العنوان: | Challenges in the Medicinal Chemical Optimization of Binding Kinetics |
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| المؤلفون: | Waring, Michael J., Leach, Andrew G., Miller, Duncan C. |
| المصدر: | Waring , M J , Leach , A G & Miller , D C 2015 , Challenges in the Medicinal Chemical Optimization of Binding Kinetics . in Thermodynamics and Kinetics of Drug Binding . John Wiley & Sons Ltd , pp. 191-210 . https://doi.org/10.1002/9783527673025.ch10Test |
| بيانات النشر: | John Wiley & Sons Ltd |
| سنة النشر: | 2015 |
| المجموعة: | The University of Manchester: Research Explorer - Publications |
| مصطلحات موضوعية: | Binding kinetics, Medicinal chemistry optimisation, Residence time, Structure-kinetic relationships |
| الوصف: | This chapter describes the key considerations and challenges to optimizing binding kinetics. The challenges relate both to our ability to measure on and off rates in a manner that informs optimization but also in our limited molecular understanding of the processes that govern on and off rates. The effects of individual molecular interactions and bulk physicochemical properties are discussed. A number of significant case studies from the literature are described, which serve to highlight these principles. These examples also illustrate that empirical optimization of residence time is possible if given adequate attention during optimization and that some of the principles discussed may have general applicability. |
| نوع الوثيقة: | book part |
| اللغة: | English |
| DOI: | 10.1002/9783527673025.ch10 |
| الإتاحة: | https://doi.org/10.1002/9783527673025.ch10Test https://research.manchester.ac.uk/en/publications/1799a53e-ad2a-4b8b-8fb8-b60005352d91Test http://www.scopus.com/inward/record.url?scp=84979719172&partnerID=8YFLogxKTest |
| حقوق: | info:eu-repo/semantics/restrictedAccess |
| رقم الانضمام: | edsbas.E927D8B8 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/9783527673025.ch10 |
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