التفاصيل البيبلوغرافية
| العنوان: |
Association of a PAI-1 Gene Polymorphism and Early Life Infections with Asthma Risk, Exacerbations, and Reduced Lung Function. |
| المؤلفون: |
Cho, Seong H., Min, Jin-Young, Kim, Dong Young, Oh, Sam S., Torgerson, Dara R., Pino-Yanes, Maria, Hu, Donglei, Sen, Saunak, Huntsman, Scott, Eng, Celeste, Farber, Harold J., Rodriguez-Cintron, William, Rodriguez-Santana, Jose R., Serebrisky, Denise, Thyne, Shannon M., Borrell, Luisa N., Williams, L. Keoki, DuPont, William, Seibold, Max A., Burchard, Esteban G. |
| المصدر: |
PLoS ONE; 8/24/2016, Vol. 11 Issue 8, p1-13, 13p |
| مصطلحات موضوعية: |
ASTHMA risk factors, LUNG physiology, GENETIC polymorphisms, PLASMINOGEN activator inhibitors, AIRWAY (Anatomy), DISEASE exacerbation |
| مستخلص: |
Background: Plasminogen activator inhibitor-1 (PAI-1) is induced in airways by virus and may mediate asthmatic airway remodeling. We sought to evaluate if genetic variants and early life lower respiratory infections jointly affect asthma risk. Methods: We included Latino children, adolescents, and young adults aged 8–21 years (1736 subjects with physician-diagnosed asthma and 1747 healthy controls) from five U.S. centers and Puerto Rico after excluding subjects with incomplete clinical or genetic data. We evaluated the independent and joint effects of a PAI-1 gain of function polymorphism and bronchiolitis / Respiratory Syncytial Virus (RSV) or other lower respiratory infections (LRI) within the first 2 years of life on asthma risk, asthma exacerbations and lung function. Results: RSV infection (OR 9.9, 95%CI 4.9–20.2) and other LRI (OR 9.1, 95%CI 7.2–11.5) were independently associated with asthma, but PAI-1 genotype was not. There were joint effects on asthma risk for both genotype-RSV (OR 17.7, 95% CI 6.3–50.2) and genotype-LRI (OR 11.7, 95% CI 8.8–16.4). A joint effect of genotype-RSV resulted in a 3.1-fold increased risk for recurrent asthma hospitalizations. In genotype-respiratory infection joint effect analysis, FEV1% predicted and FEV1/FVC % predicted were further reduced in the genotype-LRI group (β -2.1, 95% CI -4.0 to -0.2; β -2.0, 95% CI -3.1 to -0.8 respectively). Similarly, lower FEV1% predicted was noted in genotype-RSV group (β -3.1, 95% CI -6.1 to -0.2) with a trend for lower FEV1/FVC % predicted. Conclusions: A genetic variant of PAI-1 together with early life LRI such as RSV bronchiolitis is associated with an increased risk of asthma, morbidity, and reduced lung function in this Latino population. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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