دورية أكاديمية
Herpes simplex virus type 1 induces AD-like neurodegeneration markers in human progenitor and differentiated ReNcell VM cells
| العنوان: | Herpes simplex virus type 1 induces AD-like neurodegeneration markers in human progenitor and differentiated ReNcell VM cells |
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| المؤلفون: | Salgado Fuentes, Blanca, Sastre, Isabel, Bullido Gómez-Heras, María Jesús, Aldudo, Jesús |
| المساهمون: | UAM. Departamento de Biología Molecular |
| بيانات النشر: | MDPI |
| سنة النشر: | 2023 |
| المجموعة: | Universidad Autónoma de Madrid (UAM): Biblos-e Archivo |
| مصطلحات موضوعية: | Human Alphaherpesvirus 1, Infection, Fungus Antibody, Biología y Biomedicina / Biología |
| الوصف: | An increasing body of evidence strongly suggests that infections or reactivations of herpes simplex virus type 1 (HSV-1) may be closely linked to Alzheimer’s disease (AD). Promising results have been obtained using cell and animal models of HSV-1 infection, contributing to the understanding of the molecular mechanisms linking HSV-1 infection and AD neurodegeneration. ReNcell VM is a human neural stem cell line that has been used as a model system to study the impact of various infectious agents on the central nervous system. In this study, we demonstrate the suitability of the ReNcell VM cell line for developing a new in vitro model of HSV-1 infection. By following standard differentiation protocols, we were able to derive various nervous cell types, including neurons, astrocytes, and oligodendrocytes, from neural precursors. Additionally, we demonstrated the susceptibility of ReNcell VM cells, including precursor and differentiated cells, to HSV-1 infection and subsequent viral-induced AD-like neurodegeneration. Our findings support the use of this cell line to generate a new research platform for investigating AD neuropathology and its most significant risk factors, which may lead to important discoveries in the context of this highly impactful disease ; This work was funded by the Spanish Ministerio de Ciencia e Innovación (PID2020-113921RBI00) |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | Microorganisms; https://doi.org/10.3390/microorganisms11051205Test; Gobierno de España. PID2020-113921RB-I00; Microorganisms 11.5 (2023): 1205; 2076-2607 (online); http://hdl.handle.net/10486/707939Test; 1205-1; 1205-18; 11 |
| DOI: | 10.3390/microorganisms11051205 |
| الإتاحة: | https://doi.org/10.3390/microorganisms11051205Test http://hdl.handle.net/10486/707939Test |
| حقوق: | © 2023 by the authors ; Reconocimiento ; openAccess |
| رقم الانضمام: | edsbas.DC8B0718 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/microorganisms11051205 |
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