المساهمون: SeongShick Ryu, Jung-Eun Park, Young Jin Ham, Daniel C Lim, Nicholas P Kwiatkowski, Do-Hee Kim, Debabrata Bhunia, Nam Doo Kim, Michael B Yaffe, Woolim Son, Namkyoung Kim, Tae-Ik Choi, Puspanjali Swain, Cheol-Hee Kim, Jin-Young Lee, Nathanael S Gray, Kyung S Lee, Taebo Sim, Sim, Taebo

مصطلحات موضوعية: Animals, Cell Cycle Proteins / antagonists & inhibitors, Cell Cycle Proteins / chemistry, Cell Cycle Proteins / metabolism, HEK293 Cells, HeLa Cells, Humans, Molecular Docking Simulation, Molecular Structure, Peptides, Cyclic / chemical synthesis, Cyclic / metabolism, Cyclic / pharmacology, Peptidomimetics / chemical synthesis, Peptidomimetics / metabolism, Peptidomimetics / pharmacology, Protein Binding, Protein Domains, Protein Kinase Inhibitors / chemical synthesis, Protein Kinase Inhibitors / metabolism, Protein Kinase Inhibitors / pharmacology, Protein Serine-Threonine Kinases / antagonists & inhibitors, Protein Serine-Threonine Kinases / chemistry, Protein Serine-Threonine Kinases / metabolism, Proto-Oncogene Proteins / antagonists & inhibitors, Proto-Oncogene Proteins / chemistry, Proto-Oncogene Proteins / metabolism, Structure-Activity Relationship, Zebrafish

العلاقة: JOURNAL OF MEDICINAL CHEMISTRY; J01588; OAK-2022-00700; https://ir.ymlib.yonsei.ac.kr/handle/22282913/188018Test; T202200436; JOURNAL OF MEDICINAL CHEMISTRY, Vol.65(3) : 1915-1932, 2022-01

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01359Test
https://ir.ymlib.yonsei.ac.kr/handle/22282913/188018Test

المؤلفون: Yang, Z., Liang, S.Q., Yang, H., Xu, D., Bruggmann, R., Gao, Y., Deng, H., Berezowska, S., Hall, SRR, Marti, T.M., Kocher, G.J., Zhou, Q., Schmid, R.A., Peng, R.W.

المصدر: Cancer research, vol. 81, no. 11, pp. 3121-3133

مصطلحات موضوعية: Aged, Animals, Apoptosis, Benzamides/pharmacology, CRISPR-Cas Systems, Cell Cycle, Cell Cycle Proteins/antagonists & inhibitors, Cell Cycle Proteins/genetics, Cell Proliferation, Combined Modality Therapy, Gene Amplification, Gene Expression Regulation, Neoplastic, Humans, Lung Neoplasms/genetics, Lung Neoplasms/metabolism, Lung Neoplasms/pathology, Lung Neoplasms/therapy, Male, Mice, Piperazines/pharmacology, Protein Kinase Inhibitors/pharmacology, Protein Serine-Threonine Kinases/antagonists & inhibitors, Protein Serine-Threonine Kinases/genetics, Proto-Oncogene Proteins/antagonists & inhibitors, Proto-Oncogene Proteins/genetics, Pyrazoles/pharmacology, Receptor, Fibroblast Growth Factor, Type 1/antagonists & inhibitors

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33685992; info:eu-repo/semantics/altIdentifier/eissn/1538-7445; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_6D844130F3DD5; https://serval.unil.ch/notice/serval:BIB_6D844130F3DDTest; urn:issn:0008-5472; https://serval.unil.ch/resource/serval:BIB_6D844130F3DD.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6D844130F3DD5Test

الإتاحة: https://doi.org/10.1158/0008-5472.CAN-20-2276Test
https://serval.unil.ch/notice/serval:BIB_6D844130F3DDTest
https://serval.unil.ch/resource/serval:BIB_6D844130F3DD.P001/REF.pdfTest
http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_6D844130F3DD5Test

المؤلفون: Cuttano, Roberto, Rudini, Noemi, Bravi, Luca, Corada, Monica, Giampietro, Costanza, Papa, Eleanna, Morini, Marco Francesco, Maddaluno, Luigi, Baeyens, Nicolas, Adams, Ralf H, Jain, Mukesh MK, Owens, Gary GK, Schwartz, Martin A, Lampugnani, Maria Grazia, Dejana, Elisabetta

المصدر: EMBO molecular medicine, 8 (1

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Animals, Bone Morphogenetic Protein 6 -- antagonists & inhibitors -- genetics -- metabolism, Cell Proliferation, Disease Models, Animal, Disease Progression, Endothelial Cells -- cytology -- metabolism, HEK293 Cells, Hemangioma, Cavernous, Central Nervous System -- genetics -- metabolism -- pathology, Humans, Kruppel-Like Transcription Factors -- antagonists & inhibitors -- genetics -- metabolism, Mice, Inbred C57BL, Knockout, Microtubule-Associated Proteins -- antagonists & inhibitors -- genetics -- metabolism, Mitogen-Activated Protein Kinase 7 -- metabolism, Mutation, Proto-Oncogene Proteins -- antagonists & inhibitors -- genetics -- metabolism, RNA Interference, Signal Transduction, Smad1 Protein -- metabolism, Transforming Growth Factor beta -- metabolism, CCM, EndMT, KLF4, TGFβ‐BMP, endothelial cells

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.15252/emmm.201505433; uri/info:pii/emmm.201505433; uri/info:pmid/26612856; uri/info:pmcid/PMC4718159; https://dipot.ulb.ac.be/dspace/bitstream/2013/260000/4/doi_243627.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/260000Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/260000Test

المؤلفون: Andrade Da Cunha, Daniel, Igoillo Esteve, Mariana, Gurzov, Esteban Nicolas, Germano, Carla Maria Ramos C.M., Naamane, Najib, Marhfour, Ihsane, Fukaya, Makiko, Vanderwinden, Jean-Marie, Gysemans, Conny, Mathieu, Chantal, Marselli, Lorella, Marchetti, Piero, Harding, Heather HP, Ron, David, Eizirik, Decio, Cnop, Miriam

المصدر: Diabetes (New York, N.Y.), 61 (11

مصطلحات موضوعية: Sciences bio-médicales et agricoles, Aged, Animals, Apoptosis, Apoptosis Regulatory Proteins -- antagonists & inhibitors -- genetics -- metabolism, Cell Line, Cells, Cultured, Endoplasmic Reticulum Stress, Gene Expression Profiling, Humans, Insulin-Secreting Cells -- cytology -- metabolism, Male, Mice, Inbred C57BL, Knockout, Middle Aged, Mitochondria -- metabolism, Palmitic Acid -- adverse effects, Proto-Oncogene Proteins -- antagonists & inhibitors -- genetics -- metabolism, RNA Interference, RNA, Messenger -- metabolism, Small Interfering, Rats

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.2337/db12-0123; uri/info:pii/db12-0123; uri/info:pmid/22773666; uri/info:pmcid/PMC3478544; https://dipot.ulb.ac.be/dspace/bitstream/2013/222103/1/doi_205730.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/222103Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/222103Test

المؤلفون: Diviani, D., Raimondi, F., Del Vescovo, C.D., Dreyer, E., Reggi, E., Osman, H., Ruggieri, L., Gonano, C., Cavin, S., Box, C.L., Lenoir, M., Overduin, M., Bellucci, L., Seeber, M., Fanelli, F.

المصدر: Cell Chemical Biology, vol. 23, no. 9, pp. 1135-1146

مصطلحات موضوعية: A Kinase Anchor Proteins/antagonists & inhibitors, A Kinase Anchor Proteins/metabolism, Humans, Minor Histocompatibility Antigens/metabolism, Models, Molecular, Molecular Structure, Neoplasms/drug therapy, Neoplasms/metabolism, Protein Binding/drug effects, Proto-Oncogene Proteins/antagonists & inhibitors, Proto-Oncogene Proteins/metabolism, Signal Transduction/drug effects, Small Molecule Libraries/chemistry, Small Molecule Libraries/pharmacology, rho GTP-Binding Proteins/antagonists & inhibitors, rho GTP-Binding Proteins/metabolism, AKAP13 oncogene, Ras GTPases, RhoGEFs, comparative modeling, virtual screening

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27593112; info:eu-repo/semantics/altIdentifier/eissn/2451-9456; https://serval.unil.ch/notice/serval:BIB_7D29A4D26F55Test

الإتاحة: https://doi.org/10.1016/j.chembiol.2016.07.015Test
https://serval.unil.ch/notice/serval:BIB_7D29A4D26F55Test

المؤلفون: Gary Gk Owens, Roberto Cuttano, Monica Corada, Ralf H. Adams, Marco Francesco Morini, Martin A. Schwartz, Maria Grazia Lampugnani, Elisabetta Dejana, Costanza Giampietro, Luigi Maddaluno, Nicolas Baeyens, Noemi Rudini, Mukesh Mk Jain, Eleanna Papa, Luca Bravi

المصدر: EMBO molecular medicine, 8 (1
Cuttano, R, Rudini, N, Bravi, L, Corada, M, Giampietro, C, Papa, E, Morini, M F, Maddaluno, L, Baeyens, N, Adams, R H, Jain, M K, Owens, G K, Schwartz, M, Lampugnani, M G & Dejana, E 2016, ' KLF4 is a key determinant in the development and progression of cerebral cavernous malformations ', EMBO Molecular Medicine, vol. 8, no. 1, PMID 26612856, pp. 6-24 . https://doi.org/10.15252/emmm.201505433Test
EMBO Molecular Medicine, 8 (1)
EMBO Molecular Medicine

مصطلحات موضوعية: 0301 basic medicine, Hemangioma, Cavernous, Central Nervous System, Vascular Biology & Angiogenesis, Bone Morphogenetic Protein 6, Proto-Oncogene Proteins -- antagonists & inhibitors -- genetics -- metabolism, Microtubule-Associated Proteins -- antagonists & inhibitors -- genetics -- metabolism, TGF beta-BMP, Cardiovascular System, Mice, Transforming Growth Factor beta, EndMT, News & Views, KRIT1 Protein, Endothelial Cells -- cytology -- metabolism, Mice, Knockout, Basic Medicine, Sciences bio-médicales et agricoles, Phenotype, Hemangioma, Cavernous, Central Nervous System -- genetics -- metabolism -- pathology, KLF4, endothelial cells, 3. Good health, Bone morphogenetic protein 6, medicine.anatomical_structure, TGFβ‐BMP, embryonic structures, Disease Progression, Molecular Medicine, RNA Interference, Smad1 Protein -- metabolism, Signal transduction, Microtubule-Associated Proteins, Signal Transduction, CCM, Endothelial cells, TGFβ-BMP, Medicinska och farmaceutiska grundvetenskaper, Central nervous system, Kruppel-Like Transcription Factors, Mitogen-Activated Protein Kinase 7 -- metabolism, Biology, Bone morphogenetic protein, Smad1 Protein, 03 medical and health sciences, Kruppel-Like Factor 4, Kruppel-Like Transcription Factors -- antagonists & inhibitors -- genetics -- metabolism, Proto-Oncogene Proteins, medicine, Animals, Humans, Transforming Growth Factor beta -- metabolism, Mitogen-Activated Protein Kinase 7, Cell Proliferation, HEK 293 cells, Endothelial Cells, Transforming growth factor beta, Bone Morphogenetic Protein 6 -- antagonists & inhibitors -- genetics -- metabolism, Mice, Inbred C57BL, Disease Models, Animal, 030104 developmental biology, HEK293 Cells, Mutation, Cancer research, biology.protein, Genetics, Gene Therapy & Genetic Disease

وصف الملف: application/pdf; 1 full-text file(s): application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40d09206d63d5e3952c0a878de00d86eTest
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-276831Test

المؤلفون: Bruce, E, Shenoy, V, Rathinasabapathy, A, Espejo, A, Horowitz, A, Oswalt, A, Francis, J, Nair, A, Unger, T, Raizada, M K, Steckelings, Ulrike Muscha, Sumners, C, Katovich, M J

المصدر: Bruce , E , Shenoy , V , Rathinasabapathy , A , Espejo , A , Horowitz , A , Oswalt , A , Francis , J , Nair , A , Unger , T , Raizada , M K , Steckelings , U M , Sumners , C & Katovich , M J 2015 , ' Selective activation of angiotensin AT 2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis ' , British Journal of Pharmacology , vol. 172 , no. 9 , pp. 2219-2231 . https://doi.org/10.1111/bph.13044Test

مصطلحات موضوعية: Angiotensin II Type 2 Receptor Blockers/pharmacology, Angiotensin II/analogs & derivatives, Animals, Cardiovascular Agents/pharmacology, Disease Models, Animal, Fibrosis, Hemodynamics/drug effects, Hypertension, Pulmonary/chemically induced, Hypertrophy, Right Ventricular/chemically induced, Imidazoles/pharmacology, Lung/drug effects, Male, Monocrotaline, Myocardium/metabolism, Peptide Fragments/pharmacology, Proto-Oncogene Proteins/antagonists & inhibitors, Pulmonary Fibrosis/chemically induced, Pyridines/pharmacology, Rats, Sprague-Dawley, Receptor, Angiotensin, Type 2/agonists, Receptors, G-Protein-Coupled/antagonists & inhibitors, Signal Transduction/drug effects, Vascular Remodeling/drug effects

العلاقة: https://portal.findresearcher.sdu.dk/da/publications/9a3e9de0-246f-4aaf-bda2-dd58392a466dTest

الإتاحة: https://doi.org/10.1111/bph.13044Test
https://portal.findresearcher.sdu.dk/da/publications/9a3e9de0-246f-4aaf-bda2-dd58392a466dTest

المؤلفون: Bruce, E, Shenoy, V, Rathinasabapathy, A, Espejo, A, Horowitz, A, Oswalt, A, Francis, J, Nair, A, Unger, T, Raizada, M K, Steckelings, Ulrike Muscha, Sumners, C, Katovich, M J

المصدر: Bruce, E, Shenoy, V, Rathinasabapathy, A, Espejo, A, Horowitz, A, Oswalt, A, Francis, J, Nair, A, Unger, T, Raizada, M K, Steckelings, U M, Sumners, C & Katovich, M J 2015, ' Selective activation of angiotensin AT 2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis ', British Journal of Pharmacology, vol. 172, no. 9, pp. 2219-2231 . https://doi.org/10.1111/bph.13044Test

مصطلحات موضوعية: Male, Myocardium/metabolism, Pyridines, Angiotensin II Type 2 Receptor Blockers/pharmacology, Hypertension, Pulmonary, Pulmonary Fibrosis, Ventricular Dysfunction, Right, Proto-Oncogene Proteins/antagonists & inhibitors, Ventricular Remodeling/drug effects, Angiotensin II Type 2 Receptor Blockers, Vascular Remodeling, Proto-Oncogene Mas, Receptor, Angiotensin, Type 2, Receptors, G-Protein-Coupled, Rats, Sprague-Dawley, Signal Transduction/drug effects, Proto-Oncogene Proteins, Animals, Angiotensin II/analogs & derivatives, Ventricular Dysfunction, Right/chemically induced, Lung, Imidazoles/pharmacology, Pyridines/pharmacology, Receptors, G-Protein-Coupled/antagonists & inhibitors, Peptide Fragments/pharmacology, Monocrotaline, Lung/drug effects, Hypertrophy, Right Ventricular, Ventricular Remodeling, Angiotensin II, Myocardium, Ventricular Function, Right/drug effects, Hemodynamics, Imidazoles, Pulmonary Fibrosis/chemically induced, Hypertrophy, Right Ventricular/chemically induced, Cardiovascular Agents, Receptor, Angiotensin, Type 2/agonists, Research Papers, Fibrosis, Peptide Fragments, Disease Models, Animal, Hemodynamics/drug effects, Cardiovascular Agents/pharmacology, Hypertension, Pulmonary/chemically induced, Ventricular Function, Right, Vascular Remodeling/drug effects, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::b3e044c48f01f109844d8f467705bbddTest
https://europepmc.org/articles/PMC4403089Test/

المؤلفون: Gazit, Aviv, Yee, Kevin, Uecker, Andrea, Böhmer, Frank-D., Sjöblom, Tobias, Östman, Arne, Waltenberger, Johannes, Golomb, Gershon, Banai, Shmuel, Heinrich, Michael C., Levitzki, Alexander

المصدر: Bioorganic & Medicinal Chemistry. 11(9):2007-2018

مصطلحات موضوعية: Animals, Cell Line, Enzyme Inhibitors/chemistry/*pharmacology, Humans, Proto-Oncogene Proteins/*antagonists & inhibitors/metabolism, Proto-Oncogene Proteins c-kit/*metabolism, Quinoxalines/chemistry/*pharmacology, Receptor Protein-Tyrosine Kinases/*antagonists & inhibitors/metabolism, Receptors, Platelet-Derived Growth Factor/*antagonists & inhibitors/metabolism, Swine, fms-Like Tyrosine Kinase 3

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-10494Test
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed&cmd=Retrieve&list_uids=12670652&dopt=CitationTest

المؤلفون: Amiable, Claire, Paoletti, Julie, Haouz, Ahmed, Padilla, André, Labesse, Gilles, Kaminski, Pierre-Alexandre, Pochet, Sylvie

المساهمون: Université Paris Descartes - Paris 5 (UPD5), Chimie et Biocatalyse, Institut Pasteur Paris (IP)-Institut de Chimie - CNRS Chimie (INC-CNRS)-Centre National de la Recherche Scientifique (CNRS), Cristallographie (Plateforme) - Crystallography (Platform), Institut Pasteur Paris (IP)-Centre National de la Recherche Scientifique (CNRS), Centre de Biochimie Structurale Montpellier (CBS), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), This work was supported by grants from the Fondation pour la Recherche Médicale (DCM20111223063 to S. Pochet), Institut Pasteur, CNRS, INSERM and the French Infrastructure for Integrated Structural Biology (FRISBI, ANR-10-INSB-05-01)., ANR-10-INBS-0005,FRISBI,Infrastructure Française pour la Biologie Structurale Intégrée(2010)

المصدر: ISSN: 0223-5234.

مصطلحات موضوعية: Cancer, Cross-coupling reaction, Crystal structure, DNPH1, Inhibitor, Nucleoside analogues, MESH: Animals, MESH: Antineoplastic Agents/chemical synthesis, MESH: Enzyme Inhibitors/chemistry, MESH: Enzyme Inhibitors/metabolism, MESH: Enzyme Inhibitors/pharmacology, MESH: Humans, MESH: Molecular Docking Simulation, MESH: Molecular Targeted Therapy, MESH: N-Glycosyl Hydrolases/antagonists & inhibitors, MESH: N-Glycosyl Hydrolases/chemistry, MESH: N-Glycosyl Hydrolases/metabolism, MESH: Nuclear Proteins/antagonists & inhibitors, MESH: Antineoplastic Agents/chemistry, MESH: Nuclear Proteins/chemistry, MESH: Nuclear Proteins/metabolism, MESH: Protein Conformation, MESH: Proto-Oncogene Proteins/antagonists & inhibitors, MESH: Proto-Oncogene Proteins/chemistry, MESH: Proto-Oncogene Proteins/metabolism, MESH: Purine Nucleotides/chemical synthesis, MESH: Purine Nucleotides/chemistry, MESH: Purine Nucleotides/metabolism, MESH: Purine Nucleotides/pharmacology, MESH: Antineoplastic Agents/metabolism

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25108359; pasteur-01483767; https://pasteur.hal.science/pasteur-01483767Test; PUBMED: 25108359

الإتاحة: https://doi.org/10.1016/j.ejmech.2014.07.110Test
https://pasteur.hal.science/pasteur-01483767Test