المؤلفون: Banerjee, Gargi, Wilson, Duncan, Ambler, Gareth, Hostettler, Isabel Charlotte, Shakeshaft, Clare, Cohen, Hannah, Yousry, Tarek, Al-Shahi Salman, Rustam, Lip, Gregory Y H, Houlden, Henry, Muir, Keith W, Brown, Martin M, Jäger, Hans Rolf, Werring, David J, on behalf of the CROMIS-2 collaborators, Shaw, Louise, Harkness, Kirsty, Sword, Jane, MohdNor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Lovelock, Caroline, Birns, Jonathan, Cohen, David, Sekaran, L, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O’Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, O’Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Staals, Julie, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil

مصطلحات موضوعية: Cerebrovascular disease

الوصف: Objective To evaluate the influence of intracerebral haemorrhage (ICH) location on stroke outcomes. Methods We included patients recruited to a UK hospital-based, multicentre observational study of adults with imaging confirmed spontaneous ICH. The outcomes of interest were occurrence of a cerebral ischaemic event (either stroke or transient ischaemic attack) or a further ICH following study entry. Haematoma location was classified as lobar or non-lobar. Results All 1094 patients recruited to the CROMIS-2 (Clinical Relevance of Microbleeds in Stroke) ICH study were included (mean age 73.3 years; 57.4% male). There were 45 recurrent ICH events (absolute event rate (AER) 1.88 per 100 patient-years); 35 in patients presenting with lobar ICH (n=447, AER 3.77 per 100 patient-years); and 9 in patients presenting with non-lobar ICH (n=580, AER 0.69 per 100 patient-years). Multivariable Cox regression found that lobar ICH was associated with ICH recurrence (HR 8.96, 95% CI 3.36 to 23.87, p<0.0001); similar results were found in multivariable completing risk analyses. There were 70 cerebral ischaemic events (AER 2.93 per 100 patient-years); 29 in patients presenting with lobar ICH (AER 3.12 per 100 patient-years); and 39 in patients with non-lobar ICH (AER 2.97 per 100 patient-years). Multivariable Cox regression found no association with ICH location (HR 1.13, 95% CI 0.66 to 1.92, p = 0.659). Similar results were seen in completing risk analyses. Conclusions In ICH survivors, lobar ICH location was associated with a higher risk of recurrent ICH events than non-lobar ICH; ICH location did not influence risk of subsequent ischaemic events. Trial registration number NCT02513316 .

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/91/8/840Test; http://dx.doi.org/10.1136/jnnp-2020-323079Test

الإتاحة: https://doi.org/10.1136/jnnp-2020-323079Test
http://jnnp.bmj.com/cgi/content/short/91/8/840Test

المؤلفون: Hostettler, Isabel Charlotte, Morton, Matthew J, Ambler, Gareth, Kazmi, Nabila, Gaunt, Tom, Wilson, Duncan, Shakeshaft, Clare, Jäger, H R, Cohen, Hannah, Yousry, Tarek A, Al-Shahi Salman, Rustam, Lip, Gregory, Brown, Martin M, Muir, Keith, Houlden, Henry, Bulters, Diederik O, Galea, Ian, Werring, David J, On behalf of the CROMIS-2 collaborators, Aeron-Thomas, John, Aghoram, Prasanna, Amis, Elaine, Anderton, Peter, Andole, Sreeman, Anwar, Ijaz, Bamford, John, Banaras, Azra, Barry, Aian, Bellfied, Ruth, Benford, Aienne, Bhalla, Ajay, Bhargava, Maneesh, Bhaskaran, Biju, Bhupathiraju, Neelima, Birns, Jonathan, Blight, Aian, Bowring, Angie, Brown, Ellen, Bruce, David, Buck, Amanda, Bunworth, Kerry, Burger, Ilse, Burgess, Laura, Burn, Mathew, Burssens, Evelyn, Burton, Mauian, Butler, Nicola, Button, Denise, Carpenter, Michael, Chadha, Dinesh, Chatterjee, Kausik, Choy, Lillian, Cohen, David, Connell, Lynne, Cooper, Martin, Corrigan, John, Cotterill, Donna, Courtauld, Gillian, Crawford, Susan, Cullen, Claire, Dani, Krishna, Daniel, Amelia, Daniel, Prabel, Davis, Michelle, Day, Nicola, Doherty, Mandy, Douglas, Catherine, Dunne, Karen, Edwards, Collette, Eglinton, Charlotte, Elmarimi, Abduelbaset, Elmarimi, Hedley, England, Timothy, Epstein, Daniel, Epstein, Renuka, Esisi, Bernard, Evans, Rachel, Farren, Pamela, Fitzell, Pauline, Fletcher, Glyn, Gallifent, Rachel, Gascoyne, Rachel, Giallombardo, Elio, Gregary, Bindu, Gunathilagan, Gunaratam, Guyler, Paul, Hairsine, Brigid, Haley, Michael, Hardwick, Anne, Hargroves, David, Harrington, Frances, Hedstrom, Amanda, Holmes, Clare, Hussein, Senussi, Ingram, Tanya, Ispoglou, Sissi, Iveson, Liz, Johnson, Venetia, Justin, Frances, Kausar, Shahid, Kee, Karen, Keeling, Michael, Khan, Shagufta, Kieliszkowska, Agnieszka, Kingwell, Hayley, Krishnamurthy, Vinodh, Kullane, Sagal, Kumar, Balakrishna, Leach, Simon, Leason, Sana, Lopez, Paula, Luder, Robert, Madigan, Barbara, Maguire, Stuart, Maguire, Holly, Mahawish, Karim, Makawa, Linetty, Mamun, Maam, Manawadu, Dulka, Mangion, David, Manoj, Aravindakshan, Mansoor, Syed, Marsden, Tracy, Marsh, Rachel, Mashate, Sheila, McCormick, Michael, McGolick, Clare, McKee, Madeleine, Mckenzie, Emma, Meenakishundaram, Sanjeevikumar, Mellor, Zoe, Misra, Amulya, Mistri, Amit, Nor, Azlisham Mohd, Mpelembue, Mushiya, Murphy, Peter, Nallasivam, Arumug, Needle, Ann, Nguyen, Vinh, O'Connell, Janice, O’Mahony, Paul, Okwera, James, Orefo, Chukwuka, Owusu-Agyei, Peter, Parry, Anthea, Parry-Jones, Adrian, Pasco, Kath, Patterson, Chris, Peixoto, Cassilda, Perez, Jane, Persad, Nicola, Porteous, Mia, Power, Michael, Price, Christopher, Proschel, Harald, Punekar, Shuja, Putterill, Janet, Randall, Marc, Redjep, Ozlem, Rehman, Habib, Richards, Emma, Riddell, Victoria, Roffe, Christine, Rogers, Gill, Rudd, Anthony, Saastamoinen, Kari, Sajid, Mahmud, Sandhu, Banher, Schofield, Christine, Scott, Jon, Sekaran, Lakshmanan, Sharma, Pankaj, Sharma, Jagdish, Sharpe, Simon, Smith, Matthew, Smith, Anew, Sprigg, Nikola, Staals, Julie, Steele, Amy, Storey, Gail, Storey, Kelley, Subramonian, Santhosh, Sword, Jane, Tallon, Grainne, Tan, Garryck, Tate, Margaret, Teke, Jennifer, Temple, Natalie, Thompson, Teresa, Tysoe, Sharon, Vahidassr, Djamil, Kwaak, Anouk van der, Veltkamp, Roland, Walstow, Deborah, Watchurst, Caroline, Watson, Fran, Waugh, Dean, Wilkinson, Peter, Wilson, David, Wilson-Owen, Sarah, Wroath, Belinda, Wynter, Inez, Young, Emma

مصطلحات موضوعية: Cerebrovascular disease

الوصف: Objective Haptoglobin is a haemoglobin-scavenging protein that binds and neutralises free haemoglobin and modulates inflammation and endothelial progenitor cell function. A HP gene copy number variation (CNV) generates HP1 and HP2 alleles, while the single-nucleotide polymorphism rs2000999 influences their levels. The HP1 allele is hypothesised to improve outcome after spontaneous (non-traumatic) intracerebral haemorrhage (ICH). We investigated the associations of the HP CNV genotype and rs2000999 with haematoma volume, perihaematomal oedema (PHO) volume, functional outcome and mortality after ICH. Methods We included patients with neuroimaging-proven ICH, available DNA and 6-month follow-up in an observational cohort study (CROMIS-2). We classified patients into three groups according to the HP CNV: 1–1, 2–1 or 2–2 and also dichotomised HP into HP1-containing genotypes (HP1-1 and HP2-1) and HP2-2 to evaluate the HP1 allele. We measured ICH and PHO volume on CT; PHO was measured by oedema extension distance. Functional outcome was assessed by modified Rankin score (unfavourable outcome defined as mRS 3–6). Results We included 731 patients (mean age 73.4, 43.5% female). Distribution of HP CNV genotype was: HP1-1 n=132 (18.1%); HP2-1 n=342 (46.8%); and HP2-2 n=257 (35.2%). In the multivariable model mortality comparisons between HP groups, HP2-2 as reference, were as follows: OR HP1-1 0.73, 95% CI 0.34 to 1.56 (p value=0.41) and OR HP2-1 0.5, 95% CI 0.28 to 0.89 (p value=0.02) (overall p value=0.06). We found no evidence of association of HP CNV or rs200999 with functional outcome, ICH volume or PHO volume. Conclusion The HP2-1 genotype might be associated with lower 6-month mortality after ICH; this finding merits further study.

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/91/3/298Test; http://dx.doi.org/10.1136/jnnp-2019-321774Test

الإتاحة: https://doi.org/10.1136/jnnp-2019-321774Test
http://jnnp.bmj.com/cgi/content/short/91/3/298Test

المؤلفون: Nugent, J. Kevin, Lester, Barry M., Greene, Sheila M., Wieczorek-Deering, Dorith, O'Mahony, Paul

المصدر: Child Development, 1996 Aug 01. 67(4), 1806-1815.

الوصول الحر: https://www.jstor.org/stable/1131733Test

المؤلفون: Wilson, Duncan, Ambler, Gareth, Lee, Keon-Joo, Lim, Jae-Sung, Shiozawa, Masayuki, Koga, Masatoshi, Li, Linxin, Lovelock, Caroline, Chabriat, Hugues, Hennerici, Michael, Wong, Yuen Kwun, Mak, Henry Ka Fung, Prats-Sánchez, Luis, Martínez-Domeño, Alejandro, Inamura, Shigeru, Yoshifuji, Kazuhisa, Arsava, Ethem Murat, Horstmann, Solveig, Purrucker, Jan, Lam, Bonnie Yin Ka, Wong, Adrian, Kim, Young Dae, Song, Tae-Jin, Schrooten, Maarten, Lemmens, Robin, Eppinger, Sebastian, Gattringer, Thomas, Uysal, Ender, Tanriverdi, Zeynep, Bornstein, Natan M., Assayag, Einor Ben, Hallevi, Hen, Tanaka, Jun, Hara, Hideo, Coutts, Shelagh B., Hert, Lisa, Polymeris, Alexandros, Seiffge, David J., Lyrer, Philippe, Algra, Ale, Kappelle, Jaap, Al-Shahi Salman, Rustam, Jäger, Hans R., Lip, Gregory Y. H., Mattle, Heinrich P., Panos, Leonidas D., Mas, Jean-Louis, Legrand, Laurence, Karayiannis, Christopher, Phan, Thanh, Gunkel, Sarah, Christ, Nicolas, Abrigo, Jill, Leung, Thomas, Chu, Winnie, Chappell, Francesca, Makin, Stephen, Hayden, Derek, Williams, David J., Kooi, M. Eline, van Dam-Nolen, Dianne H. K., Barbato, Carmen, Browning, Simone, Wiegertjes, Kim, Tuladhar, Anil M., Maaijwee, Noortje, Guevarra, Christine, Yatawara, Chathuri, Mendyk, Anne-Marie, Delmaire, Christine, Köhler, Sebastian, van Oostenbrugge, Robert, Zhou, Ying, Xu, Chao, Hilal, Saima, Gyanwali, Bibek, Chen, Christopher, Lou, Min, Staals, Julie, Bordet, R. gis, Kandiah, Nagaendran, de Leeuw, Frank-Erik, Simister, Robert, van der Lugt, Aad, Kelly, Peter J., Wardlaw, Joanna M., Soo, Yannie, Fluri, Felix, Srikanth, Velandai, Calvet, David, Jung, Simon, Kwa, Vincent I. H., Engelter, Stefan T., Peters, Nils, Smith, Eric E., Yakushiji, Yusuke, Orken, Dilek Necioglu, Fazekas, Franz, Thijs, Vincent, Heo, Ji Hoe, Mok, Vincent, Veltkamp, Roland, Ay, Hakan, Imaizumi, Toshio, Gomez-Anson, Beatriz, Lau, Kui Kai, Jouvent, Eric, Rothwell, Peter M., Toyoda, Kazunori, Bae, Hee-Joon, Marti-Fabregas, Joan, Werring, David J., Harkness, Kirsty, Shaw, Louise, Sword, Jane, Mohd Nor, Azlisham, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Birns, Jonathan, Cohen, David, Sekaran, Lakshmanan, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, Sprigg, Nikola, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil, Shakeshaft, Clare, Brown, Martin, Charidimou, Andreas, Cohen, Hannah, Banerjee, Gargi, Houlden, Henry, White, Mark, Yousry, Tarek, Flossmann, Enrico, Muir, Keith, el-Koussy, Marwan, Gratz, Pascal, Molad, Jeremy, Korczyn, Amos, Kliper, Efrat, Maeder, Philippe, Gass, Achim, Pachai, Chahin, Bracoub, Luc, Douste-Blazy, Marie-Yvonne, Fratacci, Marie Dominique, Vicaut, Eric, Sato, Shoichiro, Miwa, Kaori, Fujita, Kyohei, Ide, Toshihiro, Ma, Henry, Ly, John, Singhal, Shahoo, Chandra, Ronil, Slater, Lee-Anne, Soufan, Cathy, Moran, Christopher, Traenka, Christopher, Thilemann, Sebastian, Fladt, Joachim, Gensicke, Henrik, Bonati, Leo, Kim, Beom Joon, Han, Moon-Ku, Kang, Jihoon, Ko, Eunbin, Yang, Mi Hwa, Jang, Myung Suk, Murphy, Sean, Carty, Fiona, Akijian, Layan, Thornton, John, Schembri, Mark, Douven, Elles, Delgado-Mederos, Raquel, Marín, Rebeca, Camps-Renom, Pol, Guisado-Alonso, Daniel, Nuñez, Fidel, Medrano-Martorell, Santiago, Merino, Elisa, Iida, Kotaro, Ikeda, Syuhei, Nishihara, Masashi, Irie, Hiroyuki, Demirelli, Derya Selcuk, Medanta, Jayesh Modi, Zerna, Charlotte, Hernández, Maria Valdés, Armitage, Paul, Heye, Anna, Muñoz-Maniega, Susana, Sakka, Eleni, Thrippleton, Michael, Dennis, Martin, Beigneux, Ysoline, Silva, Mauro, Venketasubramanian, Narayanaswamy, Ho, Shu Leung, Cheung, Raymond Tak Fai, Chan, Koon Ho, Teo, Kay Cheong, Hui, Edward, Kwan, Joseph Shiu Kwong, Chang, Richard, Tse, Man Yu, Hoi, Chu Peng, Chan, Chung Yan, Chan, Oi Ling, Cheung, Ryan Hoi Kit, Wong, Edmund Ka Ming, Leung, Kam Tat, Tsang, Suk Fung, Ip, Hing Lung, Ma, Sze Ho, Ma, Karen, Fong, Wing Chi, Li, Siu Hung, Li, Richard, Ng, Ping Wing, Wong, Kwok Kui, Liu, Wenyan, Wong, Lawrence, Ramos, Lino, de Schryver, Els, Jöbsis, Joost, van der Sande, Jaap, Brouwers, Paul, Roos, Yvo, Stam, Jan, Bakker, Stef, Verbiest, Henk, Schoonewille, Wouter, Linn, Cisca, Hertzberger, Leopold, van Gemert, Maarten, Berntsen, Paul, Hendrikse, Jeroen, Nederkoorn, Paul, Mess, Werner, Koudstaal, Peter, Leff, Alexander, Ward, Nicholas, Nachev, Parashkev, Perry, Richard, Ozkan, Hatice, Mitchell, John

المصدر: Wilson , D , Ambler , G , Lee , K-J , Lim , J-S , Shiozawa , M , Koga , M , Li , L , Lovelock , C , Chabriat , H , Hennerici , M , Wong , Y K , Mak , H K F , Prats-Sánchez , L , Martínez-Domeño , A , Inamura , S , Yoshifuji , K , Arsava , E M , Horstmann , S , Purrucker , J , Lam , B Y K , Wong , A , Kim , Y D , Song , T-J , ....

الوصف: Background: Cerebral microbleeds are a neuroimaging biomarker of stroke risk. A crucial clinical question is whether cerebral microbleeds indicate patients with recent ischaemic stroke or transient ischaemic attack in whom the rate of future intracranial haemorrhage is likely to exceed that of recurrent ischaemic stroke when treated with antithrombotic drugs. We therefore aimed to establish whether a large burden of cerebral microbleeds or particular anatomical patterns of cerebral microbleeds can identify ischaemic stroke or transient ischaemic attack patients at higher absolute risk of intracranial haemorrhage than ischaemic stroke. Methods: We did a pooled analysis of individual patient data from cohort studies in adults with recent ischaemic stroke or transient ischaemic attack. Cohorts were eligible for inclusion if they prospectively recruited adult participants with ischaemic stroke or transient ischaemic attack; included at least 50 participants; collected data on stroke events over at least 3 months follow-up; used an appropriate MRI sequence that is sensitive to magnetic susceptibility; and documented the number and anatomical distribution of cerebral microbleeds reliably using consensus criteria and validated scales. Our prespecified primary outcomes were a composite of any symptomatic intracranial haemorrhage or ischaemic stroke, symptomatic intracranial haemorrhage, and symptomatic ischaemic stroke. We registered this study with the PROSPERO international prospective register of systematic reviews, number CRD42016036602. Findings: Between Jan 1, 1996, and Dec 1, 2018, we identified 344 studies. After exclusions for ineligibility or declined requests for inclusion, 20 322 patients from 38 cohorts (over 35 225 patient-years of follow-up; median 1·34 years [IQR 0·19–2·44]) were included in our analyses. The adjusted hazard ratio [aHR] comparing patients with cerebral microbleeds to those without was 1·35 (95% CI 1·20–1·50) for the composite outcome of intracranial haemorrhage and ischaemic stroke; 2·45 ...

العلاقة: https://research.vumc.nl/en/publications/8b89e017-7580-47d4-834d-d49abdc04320Test

الإتاحة: https://doi.org/10.1016/S1474-4422Test(19)30197-8
https://research.vumc.nl/en/publications/8b89e017-7580-47d4-834d-d49abdc04320Test
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067010802&origin=inwardTest
https://www.ncbi.nlm.nih.gov/pubmed/31130428Test

المؤلفون: Corr, Mary-Louise, O'Mahony, Paul, Lovett, Jo, Kelly, Liz

المصدر: Corr , M-L , O'Mahony , P , Lovett , J & Kelly , L 2009 , Different systems, similar outcomes? Tracking attrition in reported rape cases in eleven countries : Country Briefing: Ireland . < https://cwasu.org/wp-content/uploads/2016/07/Ireland.pdfTest >

الإتاحة: https://pure.qub.ac.uk/en/publications/different-systems-similar-outcomes-tracking-attrition-in-reported-rape-cases-in-eleven-countriesTest(a292ba50-35d2-46a2-bbdb-ab7c9e53f4ac).html
https://cwasu.org/wp-content/uploads/2016/07/Ireland.pdfTest

المؤلفون: O'Mahony, Paul

المصدر: Studies: An Irish Quarterly Review, 1999 Jul 01. 88(350), 120-125.

الوصول الحر: https://www.jstor.org/stable/30096099Test

المؤلفون: O'Mahony, Paul G., Thomson, Richard G., Dobson, Ruth, Rodgers, Helen, James, Oliver F. W.

المصدر: Journal of Public Health Medicine, 1999 Jun 01. 21(2), 166-171.

الوصول الحر: https://www.jstor.org/stable/45161147Test

المؤلفون: O'Mahony, Paul G., Thomson, Richard G., Rodgers, Helen, Dobson, Ruth, James, Oliver F. W.

المصدر: Journal of Epidemiology and Community Health (1979-), 1997 Apr 01. 51(2), 206-207.

الوصول الحر: https://www.jstor.org/stable/25568442Test

المؤلفون: Banerjee, Gargi, Chan, Edgar, Ambler, Gareth, Wilson, Duncan, Cipolotti, Lisa, Shakeshaft, Clare, Cohen, Hannah, Yousry, Tarek, Lip, Gregory YH, Muir, Keith W, Brown, Martin M, Jaeger, Hans Rolf, Werring, David J, Salman, Rustam Al-Shahi, Shaw, Louise, Harkness, Kirsty, Sword, Jane, Nor, Azlisham Mohd, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Lovelock, Caroline, Birns, Jonathan, Cohen, David, Sekaran, L, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Staals, Julie, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas, Vahidassr, Djamil

الوصف: Post-stroke dementia is common but has heterogenous mechanisms that are not fully understood, particularly in patients with atrial fibrillation (AF)-related ischaemic stroke or TIA. We investigated the relationship between MRI small-vessel disease markers (including a composite cerebral amyloid angiopathy, CAA, score) and cognitive trajectory over 12 months. We included patients from the CROMIS-2 AF study without pre-existing cognitive impairment and with Montreal Cognitive Assessment (MoCA) data. Cognitive impairment was defined as MoCA < 26. We defined "reverters" as patients with an "acute" MoCA (immediately after the index event) score < 26, who then improved by ≥ 2 points at 12 months. In our cohort (n = 114), 12-month MoCA improved overall relative to acute performance (mean difference 1.69 points, 95% CI 1.03-2.36, p < 0.00001). 12-month cognitive impairment was associated with increasing CAA score (per-point increase, adjusted OR 4.09, 95% CI 1.36-12.33, p = 0.012). Of those with abnormal acute MoCA score (n = 66), 59.1% (n = 39) were "reverters". Non-reversion was associated with centrum semi-ovale perivascular spaces (per-grade increase, unadjusted OR 1.83, 95% CI 1.06-3.15, p = 0.03), cerebral microbleeds (unadjusted OR 10.86, 95% CI 1.22-96.34, p = 0.03), and (negatively) with multiple ischaemic lesions at baseline (unadjusted OR 0.11, 95% CI 0.02-0.90, p = 0.04), as well as composite small-vessel disease (per-point increase, unadjusted OR 2.91, 95% CI 1.23-6.88, p = 0.015) and CAA (per-point increase, unadjusted OR 6.71, 95% CI 2.10-21.50, p = 0.001) scores. In AF-related acute ischaemic stroke or TIA, cerebral small-vessel disease is associated both with cognitive performance at 12 months and failure to improve over this period.

وصف الملف: text

العلاقة: http://livrepository.liverpool.ac.uk/3041216/1/Banerjee2019_Article_EffectOfSmall-vesselDiseaseOnC.pdfTest; Collapse authors list. Banerjee, Gargi, Chan, Edgar, Ambler, Gareth, Wilson, Duncan, Cipolotti, Lisa, Shakeshaft, Clare, Cohen, Hannah, Yousry, Tarek, Lip, Gregory YH orcid:0000-0002-7566-1626 , Muir, Keith W et al (show 80 more authors) , Brown, Martin M, Jaeger, Hans Rolf, Werring, David J, Salman, Rustam Al-Shahi, Shaw, Louise, Harkness, Kirsty, Sword, Jane, Nor, Azlisham Mohd, Sharma, Pankaj, Kelly, Deborah, Harrington, Frances, Randall, Marc, Smith, Matthew, Mahawish, Karim, Elmarim, Abduelbaset, Esisi, Bernard, Cullen, Claire, Nallasivam, Arumug, Price, Christopher, Barry, Adrian, Roffe, Christine, Coyle, John, Hassan, Ahamad, Lovelock, Caroline, Birns, Jonathan, Cohen, David, Sekaran, L, Parry-Jones, Adrian, Parry, Anthea, Hargroves, David, Proschel, Harald, Datta, Prabel, Darawil, Khaled, Manoj, Aravindakshan, Burn, Mathew, Patterson, Chris, Giallombardo, Elio, Smyth, Nigel, Mansoor, Syed, Anwar, Ijaz, Marsh, Rachel, Ispoglou, Sissi, Chadha, Dinesh, Prabhakaran, Mathuri, Meenakishundaram, Sanjeevikumar, O'Connell, Janice, Scott, Jon, Krishnamurthy, Vinodh, Aghoram, Prasanna, McCormick, Michael, O'Mahony, Paul, Cooper, Martin, Choy, Lillian, Wilkinson, Peter, Leach, Simon, Caine, Sarah, Burger, Ilse, Gunathilagan, Gunaratam, Guyler, Paul, Emsley, Hedley, Davis, Michelle, Manawadu, Dulka, Pasco, Kath, Mamun, Maam, Luder, Robert, Sajid, Mahmud, Okwera, James, Staals, Julie, Warburton, Elizabeth, Saastamoinen, Kari, England, Timothy, Putterill, Janet, Flossman, Enrico, Power, Michael, Dani, Krishna, Mangion, David, Suman, Appu, Corrigan, John, Lawrence, Enas and Vahidassr, Djamil (2019) Effect of small-vessel disease on cognitive trajectory after atrial fibrillation-related ischaemic stroke or TIA. , Germany.

الإتاحة: https://doi.org/10.1007/s00415-019-09256-6Test
http://livrepository.liverpool.ac.uk/3041216Test/
http://livrepository.liverpool.ac.uk/3041216/1/Banerjee2019_Article_EffectOfSmall-vesselDiseaseOnC.pdfTest

المؤلفون: Cummings, Charles, Taylor, Timothy, O'Mahony, Paul

مصطلحات موضوعية: Atmosphere control, Charcoal, Re-generable, Functionalised, Volatile organic compound, Ammonia

الوصف: Charles Cummings, QinetiQ Ltd., United Kingdom ; Timothy Taylor, QinetiQ Ltd., United Kingdom ; Paul 'O'Mahony, Submarine Delivery Agency, United Kingdom ; ICES504: Management of Air Quality in Sealed Environments ; The 49th International Conference on Environmental Systems as held in Boston, Massachusetts, USA on 07 July 2019 through 11 July 2019. ; The enclosed atmosphere of a submarine must be constantly monitored and controlled to ensure the safety of the ships company. Much like National Aeronautics and Space Administration’s (NASA) Spacecraft Maximum Allowable Concentrations (SMAC) the Royal Navy (RN) have set action limits for commonplace contaminants such as Volatile Organic Compounds (VOC). Primary VOC control is achieved via surface adsorption onto activated charcoal. Over time the removal capacity of this charcoal diminishes due to the saturation of adsorption sites. This subsequently leads to filter beds requiring replacement and disposal. This constitutes a significant logistical and financial burden. Extending the usable lifetime of activated charcoal by re generation would reduce these costs. This paper discusses the feasibility of re-generating activated charcoals for repeated use on board submarines. The capacity of submarine activated charcoal was determined using typical atmosphere contaminants with a range of boiling points. Thermal, vacuum and Joule based re-generation methods and subsequent adsorption isotherms are presented. The effect of repeated adsorption and regeneration is discussed. Ammonia contamination originating from the carbon dioxide removal plants is also of concern. The findings of a laboratory investigation using alternative functionalized adsorption media to remove these compounds is presented.

وصف الملف: application/pdf

العلاقة: ICES_2019_65; https://hdl.handle.net/2346/84751Test

الإتاحة: https://hdl.handle.net/2346/84751Test