المؤلفون: Mishra, A, Zhou, B, Rodriguez-Martinez, A, Bixby, H, Singleton, RK, Carrillo-Larco, RM, Sheffer, KE, Paciorek, CJ, Bennett, JE, Lhoste, V, Iurilli, MLC, Di Cesare, M, Bentham, J, Phelps, NH, Sophiea, MK, Stevens, GA, Danaei, G, Cowan, MJ, Savin, S, Riley, LM, Gregg, EW, Aekplakorn, W, Ahmad, NA, Baker, JL, Chirita-Emandi, A, Farzadfar, F, Fink, G, Heinen, M, Ikeda, N, Kengne, AP, Khang, YH, Laatikainen, T, Laxmaiah, A, Ma, J, Monroy-Valle, M, Mridha, MK, Padez, CP, Reynolds, A, Soric, M, Starc, G, Wirth, JP, Abarca-Gomez, L, Abdeen, ZA, Abdrakhmanova, S, Ghaffar, SA, Rahim, HFA, Abdurrahmonova, Z, Abu-Rmeileh, NM, Garba, JA, Acosta-Cazares, B, Adam, I, Adamczyk, M, Adams, RJ, Adu-Afarwuah, S, Afsana, K, Afzal, S, Agbor, VN, Agdeppa, IA, Aghazadeh-Attari, J, Aguenaou, H, Aguilar-Salinas, CA, Agyemang, C, Ahmad, MH, Ahmadi, A, Ahmadi, N, Ahmed, I, Ahmed, SH, Ahrens, W, Aitmurzaeva, G, Ajlouni, K, Al-Hazzaa, HM, Al-Lahou, B, Al-Raddadi, R, Al Hourani, HM, Al Qaoud, NM, Alarouj, M, AlBuhairan, F, AlDhukair, S, Aldwairji, MA, Alexius, S, Ali, MM, Alkandari, A, Alkerwi, A, Alkhatib, BM, Allin, K, Alvarez-Pedrerol, M, Aly, E, Amarapurkar, DN, Etxezarreta, PA, Amoah, J, Amougou, N, Amouyel, P, Andersen, LB, Anderssen, SA, Androutsos, O, Angquist, L, Anjana, RM, Ansari-Moghaddam, A, Anufrieva, E, Aounallah-Skhiri, H, Araujo, J, Ariansen, I, Aris, T, Arku, RE, Arlappa, N, Aryal, KK, Aseffa, N, Aspelund, T, Assah, FK, Assembekov, B, Assuncao, MCF, Aung, MS, Auvinen, J, Avdicova, M, Avi, S, Azevedo, A, Azimi-Nezhad, M, Azizi, F, Azmin, M, Babu, BV, Jorgensen, MB, Baharudin, A, Bahijri, S, Bakacs, M, Balakrishna, N, Balanova, Y, Bamoshmoosh, M, Banach, M, Banegas, JR, Baran, J, Baran, R, Barbagallo, CM, Barbosa, V, Barcelo, A, Baretic, M, Barkat, A, Barnoya, J, Barrera, L, Barreto, M, Barros, AJD, Barros, MVG, Bartosiewicz, A, Basit, A, Bastos, JLD, Bata, I, Batieha, AM, Batista, AP, Batista, RL, Battakova, Z, Baur, LA, Bayauli, PM, Beaglehole, R, Bel-Serrat, S, Belavendra, A, Ben Romdhane, H, Benedics, J, Benet, M, Rolandi, GEB, Bere, E, Bergh, IH, Berhane, Y, Berkinbayev, S, Bernabe-Ortiz, A, Bernotiene, G, Carrasola, XB, Bettiol, H, Beutel, ME, Beybey, AF, Bezerra, J, Bhagyalaxmi, A, Bharadwaj, S, Bhargava, SK, Bi, HS, Bi, YF, Bia, D, Biasch, K, Lele, ECB, Bikbov, MM, Bista, B, Bjelica, DJ, Bjerregaard, AA, Bjerregaard, P, Bjertness, E, Bjertness, MB, Bjorkelund, C, Bloch, KV, Blokstra, A, Magnazu, MB, Bo, S, Bobak, M, Boddy, LM, Boehm, BO, Boer, JMA, Boggia, JG, Bogova, E, Boissonnet, CP, Bojesen, SE, Bonaccio, M, Bongard, V, Bonilla-Vargas, A, Bopp, M, Borghs, H, Bovet, P, Boymatova, K, Braeckevelt, L, Braeckman, L, Bragt, MCE, Brajkovich, I, Branca, F, Breckenkamp, J, Breda, J, Brenner, H, Brewster, LM, Brian, GR, Briceno, Y, Brinduse, L, Brito, M, Brophy, S, Brug, J, Bruno, G, Bugge, A, Buntinx, F, Buoncristiano, M, Burazeri, G, Burns, C, de Leon, AC, Cacciottolo, J, Cai, H, Caixeta, RB, Cama, T, Cameron, C, Camolas, J, Can, G, Candido, APC, Canete, F, Capanzana, MV, Capkova, N, Capuano, E, Capuano, R, Capuano, V, Cardol, M, Cardoso, VC, Carlsson, AC, Carmuega, E, Carvalho, J, Casajus, JA, Casanueva, FF, Casas, M, Celikcan, E, Censi, L, Cervantes-Loaiza, M, Cesar, JA, Chamukuttan, S, Chan, A, Chan, Q, Chaturvedi, HK, Chaturvedi, N, Rahim, NCA, Chee, ML, Chen, CJ, Chen, FF, Chen, HS, Chen, SH, Chen, ZM, Cheng, CY, Cheng, YLJ, Cheraghian, B, Chetrit, A, Chikova-Iscener, E, Chinapaw, MJM, Chinnock, A, Chiolero, A, Chiou, ST, Chirlaque, MD, Cho, B, Christensen, K, Christofaro, DG, Chudek, J, Cifkova, R, Cilia, M, Cinteza, E, Cirillo, M, Claessens, F, Clarke, J, Clays, E, Cohen, E, Compan-Gabucio, LM, Concin, H, Confortin, SC, Cooper, C, Coppinger, TC, Corpeleijn, E, Cortes, LY, Costanzo, S, Cottel, D, Cowell, C, Craig, CL, Crampin, AC, Cross, AJ, Crujeiras, AB, Cruz, JJ, Csanyi, T, Csilla, S, Cucu, AM, Cui, LF, Cureau, FV, Cuschieri, S, Czenczek-Lewandowska, E, D'Arrigo, G, d'Orsi, E, Dacica, L, Dallongeville, J, Damasceno, A, Damsgaard, CT, Dankner, R, Dantoft, TM, Dasgupta, P, Dastgiri, S, Dauchet, L, Davletov, K, de Assis, MAA, De Backer, G, De Bacquer, D, De Curtis, A, Hinnig, PD, de Gaetano, G, De Henauw, S, De Miguel-Etayo, P, de Oliveira, PD, De Ridder, D, De Ridder, K, de Rooij, SR, De Smedt, D, Deepa, M, Deev, AD, DeGennaro, V, Delisle, H, Delpeuch, F, Demarest, S, Dennison, E, Deren, K, Deschamps, V, Dhimal, M, Di Castelnuovo, A, Dias-da-Costa, JS, Diaz-Sanchez, ME, Diaz, A, Fernandez, PD, Ripolles, MPD, Dika, Z, Djalalinia, S, Djordjic, V, Do, HTP, Dobson, AJ, Dominguez, L, Donati, MB, Donfrancesco, C, Dong, GH, Dong, YH, Donoso, SP, Doring, A, Dorobantu, M, Dorosty, AR, Doua, K, Dragano, N, Drygas, W, Duan, JL, Duante, CA, Duboz, P, Duleva, VL, Dulskiene, V, Dumith, SC, Dushpanova, A, Dyussupova, A, Dzerve, V, Dziankowska-Zaborszczyk, E, Echeverria, G, Eddie, R, Eftekhar, E, Egbagbe, EE, Eggertsen, R, Eghtesad, S, Eiben, G, Ekelund, U, El-Khateeb, M, El Ammari, L, El Ati, J, Eldemire-Shearer, D, Eliasen, M, Elliott, P, Endevelt, R, Engle-Stone, R, Erasmus, RT, Erbel, R, Erem, C, Ergor, G, Eriksen, L, Eriksson, JG, Escobedo-de la Pena, J, Eslami, S, Esmaeili, A, Evans, A, Faeh, D, Fakhradiyev, I, Fakhretdinova, AA, Fall, CH, Faramarzi, E, Farjam, M, Sant'Angelo, VF, Fattahi, MR, Fawwad, A, Fawzi, WW, Feigl, E, Felix-Redondo, FJ, Ferguson, TS, Fernandes, RA, Fernandez-Berges, D, Ferrante, D, Ferrao, T, Ferrari, G, Ferrari, M, Ferrario, MM, Ferreccio, C, Ferreira, HS, Ferrer, E, Ferrieres, J, Figueiro, TH, Fijalkowska, A, Fisberg, M, Fischer, K, Foo, LH, Forsner, M, Fouad, HM, Francis, DK, Franco, MD, Fras, Z, Frontera, G, Fuchs, FD, Fuchs, SC, Fujiati, II, Fujita, Y, Fumihiko, M, Furdela, V, Furusawa, T, Gaciong, Z, Gafencu, M, Cuesta, MG, Galbarczyk, A, Galenkamp, H, Galeone, D, Galfo, M, Galvano, F, Gao, JL, Gao, P, Garcia-de-la-Hera, M, Merida, MJG, Solano, MG, Gareta, D, Garnett, SP, Gaspoz, JM, Gasull, M, Gaya, ACA, Gaya, AR, Gazzinelli, A, Gehring, U, Geiger, H, Geleijnse, JM, George, R, Ghaderi, E, Ghanbari, A, Ghasemi, E, Gheorghe-Fronea, OF, Gialluisi, A, Giampaoli, S, Gianfagna, F, Gieger, C, Gill, TK, Giovannelli, J, Gironella, G, Giwercman, A, Gkiouras, K, Glushkova, N, Gluskova, N, Godara, R, Godos, J, Gogen, S, Goldberg, M, Goltzman, D, Gomez, G, Gomez, JHG, Gomez, LF, Gomez, SF, Gomula, A, da Silva, BGC, Goncalves, H, Goncalves, M, Gonzalez-Alvarez, AD, Gonzalez-Chica, DA, Gonzalez-Gil, EM, Gonzalez-Gross, M, Gonzalez-Leon, M, Gonzalez-Rivas, JP, Gonzalez-Villalpando, C, Gonzalez-Villalpando, ME, Gonzalez, AR, Gottrand, F, Graca, AP, Graff-Iversen, S, Grafnetter, D, Grajda, A, Grammatikopoulou, MG, Gregor, RD, Gregorio, MJ, Groholt, EK, Grontved, A, Grosso, G, Gruden, G, Gu, DF, Guajardo, V, Gualdi-Russo, E, Guallar-Castillon, P, Gualtieri, A, Gudmundsson, EF, Gudnason, V, Guerrero, R, Guessous, I, Guimaraes, AL, Gulliford, MC, Gunnlaugsdottir, J, Gunter, MJ, Guo, XH, Guo, Y, Gupta, PC, Gupta, R, Gureje, O, Gonzalez, EG, Gutierrez, L, Gutzwiller, F, Gwee, X, Ha, S, Hadaegh, F, Hadjigeorgiou, CA, Haghshenas, R, Hakimi, H, Halkjaer, J, Hambleton, IR, Hamzeh, B, Hanekom, WA, Hange, D, Hanif, AAM, Hantunen, S, Hao, J, Hardman, CM, Kumar, RH, Lassen, TH, Harooni, J, Hashemi-Shahri, SM, Hassapidou, M, Hata, J, Haugsgjerd, T, Hayes, AJ, He, J, He, Y, He, YN, Heidinger-Felso, R, Heier, M, Hejgaard, T, Hendriks, ME, Henrique, RD, Henriques, A, Cadena, LH, Herrala, S, Herrera-Cuenca, M, Herrera, VM, Herter-Aeberli, I, Herzig, KH, Heshmat, R, Hill, AG, Ho, SY, Ho, SC, Hobbs, M, Hofelmann, DA, Holdsworth, M, Homayounfar, R, Homs, C, Hopman, WM, Horimoto, ARVR, Hormiga, CM, Horta, BL, Houti, L, Howitt, C, Htay, TT, Htet, AS, Htike, MMT, Hu, YH, Huerta, JM, Huhtaniemi, IT, Huiart, L, Petrescu, CH, Huisman, M, Husseini, A, Huu, CN, Huybrechts, I, Hwalla, N, Hyska, J, Iacoviello, L, Iakupova, EM, Ibarluzea, JM, Ibrahim, MM, Wong, NI, Ikram, MA, Iniguez, C, Iotova, V, Irazola, VE, Ishida, T, Isiguzo, GC, Islam, M, Islam, SMS, Islek, D, Ivanova-Pandourska, IY, Iwasaki, M, Jaaskelainen, T, Jackson, RT, Jacobs, JM, Jadoul, M, Jafar, T, Jallow, B, James, K, Jamil, KM, Jamrozik, K, Jansson, A, Janszky, I, Janus, E, Jarani, J, Jarvelin, MR, Jasienska, G, Jelakovic, A, Jelakovic, B, Jennings, G, Jiang, CQ, Jimenez, RO, Jockel, KH, Joffres, M, Jokelainen, JJ, Jonas, JB, Jonnagaddala, J, Jorgensen, T, Joshi, P, Josipovic, J, Joukar, F, Jozwiak, JJ, Judge, DS, Juolevi, A, Jurak, G, Simina, IJ, Juresa, V, Kaaks, R, Kaducu, FO, Kafatos, A, Kaj, M, Kajantie, EO, Kakutia, N, Kallayova, D, Kalmatayeva, Z, Kalter-Leibovici, O, Kameli, Y, Kampmann, FB, Kanala, KR, Kannan, S, Kapantais, E, Karaglani, E, Karakosta, A, Karhus, LL, Karki, KB, Katchunga, PB, Katibeh, M, Katz, J, Katzmarzyk, PT, Kauhanen, J, Kaur, P, Kavousi, M, Kazakbaeva, GM, Kaze, FF, Ke, C, Keil, U, Boker, LK, Keinanen-Kiukaanniemi, S, Kelishadi, R, Kelleher, C, Kemper, HCG, Keramati, M, Kerimkulova, A, Kersting, M, Key, T, Khader, YS, Khaledifar, A, Khalili, D, Khaw, KT, Kheiri, B, Kheradmand, M, Khosravi, A, Khouw, IMSL, Kiechl-Kohlendorfer, U, Kiechl, SJ, Kiechl, S, Killewo, J, Kim, HC, Kim, J, Kindblom, JM, Kingston, A, Klakk, H, Klimek, M, Klimont, J, Klumbiene, J, Knoflach, M, Koirala, B, Kolle, E, Kolsteren, P, Konig, J, Korpelainen, R, Korrovits, P, Korzycka, M, Kos, J, Koskinen, S, Kouda, K, Kovacs, E, Kovacs, VA, Kovalskys, I, Kowlessur, S, Koziel, S, Kratenova, J, Kratzer, W, Kriaucioniene, V, Kriemler, S, Kristensen, PL, Krizan, H, Kroker-Lobos, MF, Krokstad, S, Kromhout, D, Kruger, HS, Kruger, R, Kryst, L, Kubinova, R, Kuciene, R, Kujala, UM, Kujundzic, E, Kulaga, Z, Kulimbet, M, Kumar, RK, Kunesova, M, Kurjata, P, Kusuma, YS, Kutsenko, V, Kuulasmaa, K, Kyobutungi, C, La, QN, Laamiri, FZ, Lachat, C, Lackner, KJ, Laid, Y, Lall, L, Lam, TH, Jimenez, ML, Landais, E, Lanska, V, Lappas, G, Larijani, B, Larissa, SP, Latt, TS, Laurenzi, M, Lauria, L, Lazo-Porras, M, Le Coroller, G, Bao, KLN, Le Port, A, Le, TD, Lee, J, Lee, PH, Lehmann, N, Lehtimaki, T, Lemogoum, D, Leskosek, B, Leszczak, J, Leth-Moller, KB, Leung, GM, Levitt, NS, Li, YP, Liivak, M, Lilly, CL, Lim, C, Lim, WY, Lima-Costa, MF, Lin, HH, Lin, X, Lin, YT, Lind, L, Lingam, V, Linkohr, B, Linneberg, A, Lissner, L, Litwin, M, Liu, J, Liu, LJ, Lo, WC, Loit, HM, Long, KQ, Abril, GL, Lopes, L, Lopes, MVV, Lopes, O, Lopez-Garcia, E, Lopez, T, Lotufo, PA, Lozano, JE, Lukrafka, JL, Luksiene, D, Lundqvist, A, Lunet, N, Lunogelo, C, Lustigova, M, Luszczki, E, M'Buyamba-Kabangu, JR, Ma, GS, Ma, X, Machado-Coelho, GLL, Machado-Rodrigues, AM, Macia, E, Macieira, LM, Madar, AA, Madsen, AL, Maestre, GE, Maggi, S, Magliano, DJ, Magnacca, S, Magriplis, E, Mahasampath, G, Maire, B, Majer, M, Makdisse, M, Maki, P, Malekzadeh, F, Malekzadeh, R, Malhotra, R, Rao, KM, Malyutina, SK, Maniego, LV, Manios, Y, Manix, MI, Mann, JI, Mansour-Ghanaei, F, Manyanga, T, Manzato, E, Marcil, A, Margozzini, P, Marino, J, Markaki, A, Markey, O, Ioannidou, EM, Marques-Vidal, P, Marques, LP, Marrugat, J, Martin-Prevel, Y, Martin, R, Martorell, R, Martos, E, Maruszczak, K, Marventano, S, Masala, G, Mascarenhas, LP, Masoodi, SR, Mathiesen, EB, Mathur, P, Matijasevich, A, Matlosz, P, Matsha, TE, Matsudo, V, Mavrogianni, C, Mazur, A, Mbanya, JCN, McFarlane, SR, McGarvey, ST, McKee, M, McLachlan, S, McLean, RM, McLean, SB, McNairy, ML, McNulty, BA, Benchekor, SM, Medzioniene, J, Mehdipour, P, Mehlig, K, Mehrparvar, AH, Meirhaeghe, A, Meisfjord, J, Meisinger, C, Melgarejo, JD, Melkumova, M, Mello, J, Mendez, F, Mendivil, CO, Menezes, AMB, Menon, GR, Mensink, GBM, Menzano, MT, Meshram, II, Meto, DT, Mi, J, Michaelsen, KF, Michels, N, Mikkel, K, Milkowska, K, Miller, JC, Milushkina, O, Minderico, CS, Mini, GK, Miquel, JF, Miranda, JJ, Mirjalili, MR, Mirkopoulou, D, Mirrakhimov, E, Misigoj-Durakovic, M, Mistretta, A, Mocanu, V, Modesti, PA, Moghaddam, SS, Mohajer, B, Mohamed, MK, Mohamed, SF, Mohammad, K, Mohammadi, MR, Mohammadi, Z, Mohammadifard, N, Mohammadpourhodki, R, Mohan, V, Mohanna, S, Yusoff, MFM, Mohebbi, I, Mohebi, F, Moitry, M, Mollehave, LT, Moller, NC, Molnar, D, Momenan, A, Mondo, CK, Mendoza, RAM, Monterrubio-Flores, E, Monyeki, KDK, Moon, JS, Moosazadeh, M, Mopa, HT, Moradpour, F, Moreira, LB, Morejon, A, Moreno, LA, Morey, F, Morgan, K, Morin, SN, Mortensen, EL, Moschonis, G, Moslem, A, Mossakowska, M, Mostafa, A, Mostafavi, SA, Mota-Pinto, A, Mota, J, Motlagh, ME, Motta, J, Moura-dos-Santos, MA, Movsesyan, Y, Msyamboza, KP, Mu, TT, Muc, M, Muca, F, Mugosa, B, Muiesan, ML, Muller-Nurasyid, M, Munzel, T, Mursu, J, Murtagh, EM, Musa, KI, Milanovic, SM, Musil, V, Musinguzi, G, Muyer, MTMC, Nabipour, I, Naderimagham, S, Nagel, G, Najafi, F, Nakamura, H, Nalecz, H, Namesna, J, Nang, EEK, Nangia, VB, Nankap, M, Narake, S, Nardone, P, Naseri, T, Nauck, M, Neal, WA, Nejatizadeh, A, Nekkantti, C, Nelis, K, Nenko, I, Neovius, M, Nervi, F, Ng, TP, Nguyen, CT, Nguyen, ND, Nguyen, QN, Ni, MY, Nicolescu, R, Nie, P, Nieto-Martinez, RE, Nikitin, YP, Ning, G, Ninomiya, T, Nishi, N, Nishtar, S, Noale, M, Noboa, OA, Nogueira, H, Nordendahl, M, Nordestgaard, BG, Noto, D, Nowak-Szczepanska, N, Al Nsour, M, Nuhoglu, I, Nunes, B, Nurk, E, Nuwaha, F, Nyirenda, M, O'Neill, TW, O'Reilly, D, Obreja, G, Ochimana, C, Ochoa-Aviles, AM, Oda, E, Odili, AN, Oh, K, Ohara, K, Ohlsson, C, Ohtsuka, R, Olafsson, O, Olinto, MTA, Oliveira, IO, Omar, MA, Omar, SM, Onat, A, Ong, SK, Onland-Moret, NC, Ono, LM, Ordunez, P, Ornelas, R, Ortiz, AP, Ortiz, PJ, Osler, M, Osmond, C, Ostojic, SM, Ostovar, A, Otero, JA, Overvad, K, Owusu-Dabo, E, Paccaud, FM, Pagkalos, I, Pahomova, E, de Paiva, KM, Pajak, A, Palloni, A, Palmieri, L, Pan, WH, Panda-Jonas, S, Pandey, A, Panza, F, Paoli, M, Papadopoulou, SK, Papandreou, D, Pareja, RG, Park, SW, Park, S, Parnell, WR, Parsaeian, M, Pascanu, IM, Pasquet, P, Patel, ND, Pattussi, M, Pavlyshyn, H, Pechlaner, R, Pecin, I, Pednekar, MS, Pedro, JM, Peer, N, Peixoto, SV, Peltonen, M, Pereira, AC, Peres, MA, Perez, CM, Peterkova, V, Peters, A, Petersmann, A, Petkeviciene, J, Petrauskiene, A, Kovtun, OP, Pettenuzzo, E, Peykari, N, Pfeiffer, N, Phall, MC, Pham, ST, Pichardo, RN, Pierannunzio, D, Pigeot, I, Pikhart, H, Pilav, A, Pilotto, L, Pistelli, F, Pitakaka, F, Piwonska, A, Pizarro, AN, Plans-Rubio, P, Platonova, AG, Poh, BK, Pohlabeln, H, Polka, NS, Pop, RM, Popovic, SR, Porta, M, Posch, G, Poudyal, A, Poulimeneas, D, Pouraram, H, Pourfarzi, F, Pourshams, A, Poustchi, H, Pradeepa, R, Price, AJ, Price, JF, Prista, A, Providencia, R, Puder, JJ, Pudule, I, Puiu, M, Punab, M, Qadir, MS, Qasrawi, RF, Qorbani, M, Quintana, HK, Quiroga-Padilla, PJ, Bao, TQ, Rach, S, Radic, I, Radisauskas, R, Rahimikazerooni, S, Rahman, M, Raitakari, O, Raj, M, Rajabov, T, Rakhmatulloev, S, Rakovac, I, Rao, SR, Ramachandran, A, Ramadan, OPC, Ramires, VV, Ramke, J, Ramos, E, Ramos, R, Rampal, L, Rampal, S, Rangelova, LS, Rarra, V, Rascon-Pacheco, RA, Rech, CR, Redon, J, Reganit, PFM, Regecova, V, Renner, JDP, Repasy, JA, Reuter, CP, Revilla, L, Rezaianzadeh, A, Rho, Y, Ribas-Barba, L, Ribeiro, R, Riboli, E, Richter, A, Rigo, F, Rigotti, A, Rinaldo, N, de Wit, TFR, Rito, AI, Ritti-Dias, RM, Rivera, JA, Roa, RG, Robinson, L, Robitaille, C, Roccaldo, R, Rodrigues, D, Rodriguez-Artalejo, F, Rodriguez-Perez, MD, Rodriguez-Villamizar, LA, Rodriguez, AY, Roggenbuck, U, Rohloff, P, Rohner, F, Rojas-Martinez, R, Rojroongwasinkul, N, Romaguera, D, Romeo, EL, Rosario, RV, Rosengren, A, Rouse, I, Rouzier, V, Roy, JGR, Ruano, MH, Rubinstein, A, Ruhli, FJ, Ruidavets, JB, Ruiz-Betancourt, BS, Ruiz-Castell, M, Moreno, ER, Rusakova, IA, Jonsson, KR, Russo, P, Rust, P, Rutkowski, M, Saamel, M, Sabanayagam, C, Sabbaghi, H, Sacchini, E, Sachdev, HS, Sadjadi, A, Safarpour, AR, Safi, S, Safiri, S, Saghi, MH, Saidi, O, Saki, N, Salaj, S, Salanave, B, Martinez, ES, Saleva, C, Salmeron, D, Salomaa, V, Salonen, JT, Salvetti, M, Samoutian, M, Sanchez-Abanto, J, Rodriguez, IS, andjaja, Sans, S, Marina, LS, Santacruz, E, Santos, DA, Santos, IS, Santos, LC, Santos, MP, Santos, O, Santos, R, Santos, TR, Saramies, JL, Sardinha, LB, Sarrafzadegan, N, Sathish, T, Saum, KU, Savva, S, Savy, M, Sawada, N, Sbaraini, M, Scazufca, M, Schaan, BD, Rosario, AS, Schargrodsky, H, Schienkiewitz, A, Schindler, K, Schipf, S, Schmidt, CO, Schmidt, IM, Schneider, A, Schnohr, P, Schottker, B, Schramm, S, Schroder, H, Schultsz, C, Schulze, MB, Schutte, AE, Sebert, S, Sedaghattalab, M, Selamat, R, Sember, V, Sen, A, Senbanjo, IO, Sepanlou, SG, Sequera, G, Serra-Majem, L, Servais, J, Sevcikova, L, Shalnova, S, Shamah-Levy, T, Shamshirgaran, SM, Shanthirani, CS, Sharafkhah, M, Sharma, SK, Shaw, JE, Shayanrad, A, Shayesteh, AA, Shengelia, L, Shi, ZM, Shibuya, K, Shimizu-Furusawa, H, Shimony, T, Shiri, R, Shrestha, N, Si-Ramlee, K, Siani, A, Siantar, R, Sibai, AM, Sidossis, LS, Silitrari, N, Silva, AM, Silva, CRD, Silva, DAS, Silva, KS, Sim, XL, Simon, M, Simons, J, Simons, LA, Sjoberg, A, Sjostrom, M, Skoblina, NA, Skodje, G, Slazhnyova, T, Slowikowska-Hilczer, J, Slusarczyk, P, Smeeth, L, So, HK, Soares, FC, Sobek, G, Sobngwi, E, Sodemann, M, Soderberg, S, Soekatri, MYE, Soemantri, A, Sofat, R, Solfrizzi, V, Somi, MH, Sonestedt, E, Song, Y, Soofi, S, Sorensen, TIA, Sorgjerd, EP, Jerome, CS, Soto-Rojas, VE, Soumare, A, Sousa-Poza, A, Sovic, S, Sparboe-Nilsen, B, Sparrenberger, K, Spencer, PR, Spinelli, A, Spiroski, I, Staessen, JA, Stamm, H, Staub, K, Stavreski, B, Steene-Johannessen, J, Stehle, P, Stein, AD, Stergiou, GS, Stessman, J, Stevanovic, R, Stieber, J, Stockl, D, Stokwiszewski, J, Stoyanova, E, Stratton, G, Stronks, K, Strufaldi, MW, Sturua, L, Suarez-Medina, R, Suka, M, Sun, CA, Sun, L, Sundstrom, J, Sung, YT, Sunyer, J, Suriyawongpaisal, P, Sweis, NWG, Swinburn, BA, Sy, RG, Sylva, RC, Szklo, M, Szponar, L, Tabone, L, Tai, ESO, Tambalis, KD, Tammesoo, ML, Tamosiunas, A, Tan, EJ, Tang, X, Tanrygulyyeva, M, Tanser, F, Tao, Y, Tarawneh, MR, Tarp, J, Tarqui-Mamani, CB, Braunerova, RT, Taylor, A, Taylor, J, Tchibindat, F, Te Velde, S, Tebar, WR, Tell, GS, Tello, T, Tham, YC, Thankappan, KR, Theobald, H, Theodoridis, X, Thomas, N, Thorand, B, Thuesen, BH, Ticha, L, Timmermans, EJ, Tjandrarini, DH, Tjonneland, A, Tolonen, HK, Tolstrup, JS, Topbas, M, Topor-Madry, R, Torheim, LE, Tormo, MJ, Tornaritis, MJ, Torrent, M, Torres-Collado, L, Toselli, S, Touloumi, G, Traissac, P, Tran, TTH, Tremblay, MS, Triantafyllou, A, Trichopoulos, D, Trichopoulou, A, Trinh, OTH, Trivedi, A, Tsao, YH, Tshepo, L, Tsigga, M, Tsintavis, P, Tsugane, S, Tuitele, J, Tuliakova, AM, Tulloch-Reid, MK, Tullu, F, Tuomainen, TP, Tuomilehto, J, Turley, ML, Twig, G, Tynelius, P, Tzala, E, Tzotzas, T, Tzourio, C, Ueda, P, Ugel, E, Ukoli, FAM, Ulmer, H, Unal, B, Usupova, Z, Uusitalo, HMT, Uysal, N, Vaitkeviciute, J, Valdivia, G, Vale, S, Valvi, D, van Dam, RM, van den Born, BJ, Van der Heyden, J, van der Schouw, YT, Van Herck, K, Van Lippevelde, W, Minh, HV, Van Schoor, NM, van Valkengoed, IGM, Vanderschueren, D, Vanuzzo, D, Varbo, A, Varela-Moreiras, G, Vargas, LN, Varona-Perez, P, Vasan, SK, Vasques, DG, Vega, T, Veidebaum, T, Velasquez-Melendez, G, Velika, B, Verloigne, M, Veronesi, G, Verschuren, WMM, Victora, CG, Viegi, G, Viet, L, Vik, FN, Vilar, M, Villalpando, S, Vioque, J, Virtanen, JK, Visvikis-Siest, S, Viswanathan, B, Vladulescu, M, Vlasoff, T, Vocanec, D, Vollenweider, P, Volzke, H, Voutilainen, A, Vrijheid, M, Vrijkotte, TGM, Wade, AN, Waldhor, T, Walton, J, Wambiya, EOA, Bebakar, WMW, Mohamud, WNW, Wanderley, RD Jr, Wang, MD, Wang, NL, Wang, Q, Wang, XJ, Wang, YX, Wang, YW, Wannamethee, SG, Wareham, N, Weber, A, Webster-Kerr, K, Wedderkopp, N, Weghuber, D, Wei, WB, Weres, A, Werner, B, Westbury, LD, Whincup, PH, Wickramasinghe, K, Widhalm, K, Widyahening, IS, Wiecek, A, Wild, PS, Wilks, RJ, Willeit, J, Willeit, P, Williams, J, Wilsgaard, T, Wojciech, R, Wojtyniak, B, Wolf, K, Wong-McClure, RA, Wong, A, Wong, EB, Wong, JE, Wong, TY, Woo, J, Woodward, M, Wu, FC, Wu, HY, Wu, JF, Wu, LJ, Wu, SL, Wyszynska, J, Xu, HQ, Xu, L, Yaacob, NA, Yamborisut, U, Yan, WL, Yang, L, Yang, XG, Yang, Y, Yardim, N, Yasuharu, T, Garcia, MY, Yiallouros, PK, Yngve, A, Yoosefi, M, Yoshihara, A, You, QS, You, SL, Younger-Coleman, NO, Yu, YL, Yu, YJ, Yusof, SM, Yusoff, AF, Zaccagni, L, Zafiropulos, V, Zainuddin, AA, Zakavi, SR, Zamani, F, Zambon, S, Zampelas, A, Zamrazilova, H, Zapata, ME, Zargar, AH, Zaw, KK, Zayed, AA, Zdrojewski, T, Zeglen, M, Zejglicova, K, Vrkic, TZ, Zeng, Y, Zhang, LX, Zhang, ZY, Zhao, D, Zhao, MH, Zhao, WH, Zhecheva, YV, Zhen, SQ, Zheng, W, Zheng, YF, Zholdin, B, Zhou, MG, Zhu, D, Zins, M, Zitt, E, Zocalo, Y, Zoghlami, N, Cisneros, JZ, Zuziak, M, Bhutta, ZA, Black, RE, Ezzati, M

المصدر: Nature. 615(7954):874-883

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:153300414Test

المؤلفون: Trpchevska, N, Freidin, MB, Broer, L, Oosterloo, BC, Yao, SY, Zhou, YT, Vona, B, Bishop, C, Bizaki-Vallaskangas, A, Canlon, B, Castellana, F, Chasman, DI, Cherny, S, Christensen, K, Concas, MP, Correa, A, Elkon, R, Mengel-From, J, Gao, Y, Giersch, ABS, Girotto, G, Gudjonsson, A, Gudnason, V, Heard-Costa, NL, Hertzano, R, Hjelmborg, JVB, Hjerling-Leffler, J, Hoffman, HJ, Kaprio, J, Kettunen, J, Krebs, K, Kahler, AK, Lallemend, F, Launer, LJ, Lee, IM, Leonard, H, Li, CM, Lowenheim, H, Magnusson, PKE, van Meurs, J, Milani, L, Morton, CC, Makitie, A, Nalls, MA, Nardone, GG, Nygaard, M, Palviainen, T, Pratt, S, Quaranta, N, Ramo, J, Saarentaus, E, Sardone, R, Satizabal, CL, Schweinfurth, JM, Seshadri, S, Shiroma, E, Shulman, E, Simonsick, E, Spankovich, C, Tropitzsch, A, Lauschke, VM, Sullivan, PF, Goedegebure, A, Cederroth, CR, Williams, FM, Nagtegaal, AP

المصدر: American journal of human genetics. 109(6):1077-1091

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:150182567Test

المؤلفون: Riddell, A, Cook, A, Khavessian, N, Ellis, S, Bilardi, D, Correia, E, Kostyanev, T, Nardone, A, Russell, N, Vilken, T, Stohr, W, Adhisivam, B, de Moraes, IRA, Ahmed, NU, Bekker, A, Berezin, EN, Boonkasidecha, S, Carvalheiro, CG, Chauhan, P, Chiurchiu, S, Chorafa, E, Dramowski, A, Madhusudhan, DS, Feng, JX, Jia, SN, Kong, Y, Kyohere, M, Kontou, A, Lochindarat, S, De Luca, M, Mphaphuli, A, Mussi-Pinhata, MM, Murunga, S, Nakwa, FL, Nangia, S, Nassolo, E, Hoang, NTB, Obiero, CW, Olson, L, Ping, W, Plakkal, N, Prasad, P, Preedisripipat, K, Rahman, SW, Seef, T, Sukrakanchana, PO, Thomas, R, Yu, Z, Zhang, QR, Walker, AS, Bielicki, J, Heath, PT, Sharland, M, Munera-Huertas, T

المصدر: Antibiotics (Basel, Switzerland). 12(5)

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:153132342Test

المؤلفون: Albert Grinshpun, Douglas Russo, Wen Ma, Ana Verma, Francisco Hermida-Prado, Shira Sherman, Giorgio Gaglia, Sheheryar Kabraji, Gregory Kirkner, Melissa E. Hughes, Nancy U. Lin, Zachary Sandusky, Agostina Nardone, Cristina Guarducci, Quang-De Nguyen, Sandro Santagata, Zsuzsanna Nagy, Rinath Jeselsohn

المصدر: npj Breast Cancer, Vol 10, Iss 1, Pp 1-12 (2024)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract The ESR1 ligand binding domain activating mutations are the most prevalent genetic mechanism of acquired endocrine resistance in metastatic hormone receptor-positive breast cancer. These mutations confer endocrine resistance that remains estrogen receptor (ER) dependent. We hypothesized that in the presence of the ER mutations, continued ER blockade with endocrine therapies that target mutant ER is essential for tumor suppression even with chemotherapy treatment. Here, we conducted comprehensive pre-clinical in vitro and in vivo experiments testing the efficacy of adding fulvestrant to fluorouracil (5FU) and the 5FU pro-drug, capecitabine, in models of wild-type (WT) and mutant ER. Our findings revealed that while this combination had an additive effect in the presence of WT-ER, in the presence of the Y537S ER mutation there was synergy. Notably, these effects were not seen with the combination of 5FU and selective estrogen receptor modulators, such as tamoxifen, or in the absence of intact P53. Likewise, in a patient-derived xenograft (PDX) harboring a Y537S ER mutation the addition of fulvestrant to capecitabine potentiated tumor suppression. Moreover, multiplex immunofluorescence revealed that this effect was due to decreased cell proliferation in all cells expressing ER and was not dependent on the degree of ER expression. Taken together, these results support the clinical investigation of the combination of ER antagonists with capecitabine in patients with metastatic hormone receptor-positive breast cancer who have experienced progression on endocrine therapy and targeted therapies, particularly in the presence of an ESR1 activating mutation.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2374-4677Test

الوصول الحر: https://doaj.org/article/7c7a103652a4404eac1f649798184d56Test

المؤلفون: Chappell, E, Turkova, A, Goetghebuer, T, Jackson, C, Chiappini, E, Galli, L, Gingaras, C, Judd, A, Spoulou, V, Lisi, C, Ansone, S, Wolfs, T, Marczynska, M, Ene, L, Plotnikova, Y, Voronin, E, Samarina, A, Jourdain, G, Ngo-Giang-Huong, N, Fortuny, C, Navarro, ML, Ramos, JT, Naver, L, Crisinel, PA, Bailey, H, Malyuta, R, Volokha, A, Bamford, A, Crichton, S, Foster, C, Thorne, C, Collins, IJ, Giaquinto, C, Gibb, DM, Critchton, S, Duff, C, Goodall, R, Gomezpena, D, Lundin, R, Mangiarini, L, Milanzi, E, Nardone, A, Hainaut, M, Van der Kelen, E, Delforge, M, de Martino, M, Tovo, PA, Gabiano, C, Carloni, I, Larovere, D, Baldi, F, Miniaci, A, Pession, A, Badolato, R, Panto, G, Anastasio, E, Montagnani, C, Venturini, E, Bianchi, L, Allodi, A, Di Biagio, A, Grignolo, S, Giacomet, V, Marchisio, P, Banderali, G, Tagliabue, C, Cellini, M, Bruzzese, E, Di Costanzo, P, Lo Vecchio, A, Dona, D, Rampon, O, Romano, A, Dodi, I, Esposito, S, Zuccaro, V, Zanaboni, D, Consolini, R, Bernardi, S, Genovese, O, Cristiano, L, Mazza, A, Garazzino, S, Mignone, F, Silvestro, E, Portelli, V, Pajkrt, D, Scherpbier, HJ, Weijsenfeld, AM, de Boer, CG, Jurriaans, S, Back, NKT, Zaaijer, HL, Berkhout, B, Cornelissen, MTE, Schinkel, CJ, Wolthers, KC, Fraaij, PLA, van Rossum, AMC, Vermont, CL, van der Knaap, LC, Visser, EG, Boucher, CAB, Koopmans, MPG, van Kampen, JJA, Pas, SD, Henriet, SSV, van de Flier, M, van Aerde, K, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, FF, Scholvinck, EH, de Groot-de Jonge, H, Niesters, HGM, van Leer-Buter, CC, Knoester, M, Bont, LJ, Geelen, SPM, Wolfs, TFW, Nauta, N, Schuurman, R, Verduyn-Lunel, F, Wensing, AMJ, Reiss, P, Zaheri, S, Bezemer, DO, van Sighem, AI, Smit, C, Wit, FWMN, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Grivell, S, Meijering, R, Raethke, M, Rutkens, T, de Groot, L, van den Akker, M, Bakker, Y, Bezemer, M, El Berkaoui, A, Geerlinks, J, Koops, J, Kruijne, E, Lodewijk, C, Lucas, E, van der Meer, R, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, van de Sande, L, Schoorl, M, Schnorr, P, Tuijn, E, Veenenberg, L, van der Vliet, S, Wisse, A, Witte, EC, Tuk, B, Popielska, J, Pokorska-Spiewak, M, Oldakowska, A, Zawadka, K, Coupland, U, Doroba, M, Okhonskaia, L, Miloenko, M, Labutina, S, Soler-Palacin, P, Frick, MA, Perez-Hoyos, S, Mur, A, Lopez, N, Mendez, M, Mayol, L, Vallmanya, T, Calavia, O, Garcia, L, Coll, M, Pineda, V, Rius, N, Rovira, N, Duenas, J, Noguera-Julian, A, Mellado, MJ, Escosa, L, Hortelano, MG, Sainz, T, Gonzalez-Tome, MI, Rojo, P, Blazquez, D, Prieto, L, Guillen, S, Saavedra, J, Santos, M, Munoz, MA, Ruiz, B, Mc Phee, CF, de Ory, SJ, Alvarez, S, Roa, MA, Beceiro, J, Martinez, J, Badillo, K, Apilanez, M, Pocheville, I, Garrote, E, Colino, E, Sirvent, JG, Garzon, M, Roman, V, Montesdeoca, A, Mateo, M, Munoz, MJ, Angulo, R, Neth, O, Falcon, L, Terol, P, Santos, JL, Moreno, D, Lendinez, F, Grande, A, Romero, FJ, Perez, C, Lillo, M, Losada, B, Herranz, M, Bustillo, M, Guerrero, C, Collado, P, Couceiro, JA, Perez, A, Piqueras, AI, Breton, R, Segarra, I, Gavilan, C, Jareno, E, Montesinos, E, Dapena, M, Alvarez, C, Andres, AG, Marugan, V, Ochoa, C, Alfayate, S, Menasalvas, AI, de Miguel, E, Soeria-Atmadja, S, Belfrage, E, Hagas, V, Aebi-Popp, K, Anagnostopoulos, A, Asner, S, Battegay, M, Baumann, M, Bernasconi, E, Boni, J, Braun, DL, Bucher, HC, Calmy, A, Cavassini, M, Ciuffi, A, Duppenthaler, A, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Francini, K, Furrer, H, Fux, CA, Grawe, C, Gunthard, HF, Haerry, D, Hasse, B, Hirsch, HH, Hoffmann, M, Hosli, I, Huber, M, Kahlert, CR, Kaiser, L, Keiser, O, Klimkait, T, Kottanattu, L, Kouyos, RD, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, BM, Marzolini, C, Metzner, KJ, Muller, N, Nicca, D, Paioni, P, Pantaleo, G, Perreau, M, Ch, P, Rauch, A, Rudin, C, Scherrer, AU, Schmid, P, Speck, R, Stockle, M, Tarr, P, Lecompte, MT, Trkola, A, Vernazza, P, Wagner, N, Wandeler, G, Weber, R, Wyler, CA, Yerly, S, Wannarit, P, Techakunakorn, P, Hansudewechakul, R, Kham, C, Wanchaitanawong, V, Theansavettrakul, S, Sai, M, Nanta, S, Ngampiyaskul, C, Phanomcheong, S, Hongsiriwon, S, Karnchanamayul, W, Chacheongsao, B, Kwanchaipanich, R, Kanjanavanit, S, Prapinklao, S, Kamonpakorn, N, Nantarukchaikul, M, Adulyadej, B, Layangool, P, Mekmullica, J, Lucksanapisitkul, P, Watanayothin, S, Lertpienthum, N, Yai, H, Warachit, B, Kaen, K, Hanpinitsak, S, Khai, N, Potchalongsin, S, Thanasiri, P, Krikajornkitti, S, Attavinijtrakarn, P, Srirojana, S, Bunjongpak, S, Puangsombat, A, Na-Rajsima, S, Ananpatharachai, P, Akarathum, N, Phuket, V, Lawtongkum, W, Kheunjan, P, Suriyaboon, T, Saipanya, A, Than-In-At, K, Jaisieng, N, Suaysod, R, Chailoet, S, Naratee, N, Kawilapat, S, Kaleeva, T, Baryshnikova, Y, Soloha, S, Bashkatova, N, Raus, I, Glutshenko, O, Ruban, Z, Prymak, N, Kiseleva, G, Lyall, H, Butler, K, Doerholt, K, Doherty, C, Harrison, I, Kenny, J, Klein, N, Letting, G, McMaster, P, Murau, F, Nsangi, E, Prime, K, Riordan, A, Shackley, F, Shingadia, D, Storey, S, Tudor-Williams, G, Welch, S, Cook, C, Dobson, D, Fairbrother, K, Le Prevost, M, Van Looy, N, Peters, H, Francis, K, Thrasyvoulou, L, Fidler, K, Bernatoniene, J, Manyika, F, Sharpe, G, Subramaniam, B, Hague, R, Price, V, Flynn, J, Cardoso, A, Abou-Rayyah, M, Yeadon, S, Segal, S, Hawkins, S, Dowie, M, Bandi, S, Percival, E, Eisenhut, M, Duncan, K, Anguvaa, L, Wren, L, Flood, T, Pickering, A, Murphy, C, Daniels, J, Lees, Y, Thompson, F, Williams, A, Williams, B, Pope, S, Libeschutz, S, Cliffe, L, Southall, S, Freeman, A, Freeman, H, Christie, S, Gordon, A, Hague, DR, Clarke, L, Jones, L, Brown, L, Greenberg, M, Benson, C, Ibberson, L, Patel, S, Hancock, J, Sharland, M, Lyall, EGH, Seery, P, Kirkhope, N, Raghunanan, S, Callaghan, A, Bridgwood, A, Evans, J, Blake, E, Yannoulias, A

المصدر: AIDS (London, England). 35(12):1973-1985

مصطلحات موضوعية: Medicin och hälsovetenskap, Klinisk medicin, Infektionsmedicin, Pediatrik, Hälsovetenskap, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:147953831Test

المؤلفون: Sara Del Tufo, Umberto Atripaldi, Antonella Nicastro, Iacopo Panarese, Davide Ciardiello, Valerio Nardone, Francesco Selvaggi, Roberto Grassi, Salvatore Cappabianca, Erika Martinelli, Alfonso Reginelli

المصدر: Radiology Case Reports, Vol 19, Iss 9, Pp 3626-3630 (2024)

مصطلحات موضوعية: Rectal cancer, Biomarkers, Perineural invasion, MRI, Staging, Medical physics. Medical radiology. Nuclear medicine, R895-920

الوصف: Treatment of rectal cancer has improved over the years thanks to a multidisciplinary approach. A correct staging has a fundamental role for risk stratification and to define the best treatment for each patient. Unfortunately, approximately 30% of patients with locally advanced rectal cancers will experience tumor recurrence. Thus, the identification of novel clinical-pathological and radiological prognostic factors represents an urgent unmet clinical need. Here we report the case of a patient with radically resected localized rectal cancer who developed an impressive early pelvic recurrence. To better understand the clinical scenario, we have studied the possible factors related to the aggressiveness of the disease. The only poor prognosticfactor that was evidenced at histological report was perineural invasion. Therefore, we questioned whether we could evaluate perineural invasion with imaging, similar to head and neck tumors. Learning from this clinical case, we believe that improving the risk stratification and radiology reporting is necessary to provide the best care for the patient and allow for a better prognosis prediction. Of course, our data should be considered as hypothesis generating and should be further investigated and validated in larger and prospective studies.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S193004332400428XTest; https://doaj.org/toc/1930-0433Test

الوصول الحر: https://doaj.org/article/eec5cbb29fdd4342a5a6cb660c4ec7b4Test

المؤلفون: Longo V., Della Corte C. M., Russo A., Spinnato F., Ambrosio F., Ronga R., Marchese A., Del Giudice T., Sergi C., Casaluce F., Gilli M., Montrone M., Gristina V., Sforza V., Reale M. L., Di Liello R., Servetto A., Lipari H., Longhitano C., Vizzini L., Manzo A., Cristofano A., Paolelli L., Nardone A., De Summa S., Perrone A., Bisceglia C., Derosa C., Nardone V., Viscardi G., Galetta D., Vitiello F.

المساهمون: Longo V., Della Corte C.M., Russo A., Spinnato F., Ambrosio F., Ronga R., Marchese A., Del Giudice T., Sergi C., Casaluce F., Gilli M., Montrone M., Gristina V., Sforza V., Reale M.L., Di Liello R., Servetto A., Lipari H., Longhitano C., Vizzini L., Manzo A., Cristofano A., Paolelli L., Nardone A., De Summa S., Perrone A., Bisceglia C., Derosa C., Nardone V., Viscardi G., Galetta D., Vitiello F.

مصطلحات موضوعية: chemoimmunotherapy, consolidative radiotherapy, innate immunity, safety, SCLC - small cell lung cancer

الوصف: Background: Consolidative thoracic radiotherapy (TRT) has been commonly used in the management of extensive-stage small cell lung cancer (ES-SCLC). Nevertheless, phase III trials exploring first-line chemoimmunotherapy have excluded this treatment approach. However, there is a strong biological rationale to support the use of radiotherapy (RT) as a boost to sustain anti-tumor immune responses. Currently, the benefit of TRT after chemoimmunotherapy remains unclear. The present report describes the real-world experiences of 120 patients with ES-SCLC treated with different chemoimmunotherapy combinations. Preclinical data supporting the hypothesis of anti-tumor immune responses induced by RT are also presented. Methods: A total of 120 ES-SCLC patients treated with chemoimmunotherapy since 2019 in the South of Italy were retrospectively analyzed. None of the patients included in the analysis experienced disease progression after undergoing first-line chemoimmunotherapy. Of these, 59 patients underwent TRT after a multidisciplinary decision by the treatment team. Patient characteristics, chemoimmunotherapy schedule, and timing of TRT onset were assessed. Safety served as the primary endpoint, while efficacy measured in terms of overall survival (OS) and progression-free survival (PFS) was used as the secondary endpoint. Immune pathway activation induced by RT in SCLC cells was explored to investigate the biological rationale for combining RT and immunotherapy. Results: Preclinical data supported the activation of innate immune pathways, including the STimulator of INterferon pathway (STING), gamma-interferon-inducible protein (IFI-16), and mitochondrial antiviral-signaling protein (MAVS) related to DNA and RNA release. Clinical data showed that TRT was associated with a good safety profile. Of the 59 patients treated with TRT, only 10% experienced radiation toxicity, while no ≥ G3 radiation-induced adverse events occurred. The median time for TRT onset after cycles of chemoimmunotherapy was 62 days. Total radiation ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/38304255; info:eu-repo/semantics/altIdentifier/wos/WOS:001154316800001; volume:14; firstpage:1; lastpage:9; numberofpages:9; journal:FRONTIERS IN IMMUNOLOGY; https://hdl.handle.net/10447/623973Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85183811990

الإتاحة: https://doi.org/10.3389/fimmu.2023.1289434Test
https://hdl.handle.net/10447/623973Test

المؤلفون: Stefano Nardone, Roberto De Luca, Antonino Zito, Nataliya Klymko, Dimitris Nicoloutsopoulos, Oren Amsalem, Cory Brannigan, Jon M. Resch, Christopher L. Jacobs, Deepti Pant, Molly Veregge, Harini Srinivasan, Ryan M. Grippo, Zongfang Yang, Mark L. Zeidel, Mark L. Andermann, Kenneth D. Harris, Linus T. Tsai, Elda Arrigoni, Anne M. J. Verstegen, Clifford B. Saper, Bradford B. Lowell

المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-21 (2024)

مصطلحات موضوعية: Science

الوصف: Abstract The “dorsal pons”, or “dorsal pontine tegmentum” (dPnTg), is part of the brainstem. It is a complex, densely packed region whose nuclei are involved in regulating many vital functions. Notable among them are the parabrachial nucleus, the Kölliker Fuse, the Barrington nucleus, the locus coeruleus, and the dorsal, laterodorsal, and ventral tegmental nuclei. In this study, we applied single-nucleus RNA-seq (snRNA-seq) to resolve neuronal subtypes based on their unique transcriptional profiles and then used multiplexed error robust fluorescence in situ hybridization (MERFISH) to map them spatially. We sampled ~1 million cells across the dPnTg and defined the spatial distribution of over 120 neuronal subtypes. Our analysis identified an unpredicted high transcriptional diversity in this region and pinpointed the unique marker genes of many neuronal subtypes. We also demonstrated that many neuronal subtypes are transcriptionally similar between humans and mice, enhancing this study’s translational value. Finally, we developed a freely accessible, GPU and CPU-powered dashboard ( http://harvard.heavy.ai:6273Test/ ) that combines interactive visual analytics and hardware-accelerated SQL into a data science framework to allow the scientific community to query and gain insights into the data.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2041-1723Test

الوصول الحر: https://doaj.org/article/f281b415638047cf935491423b9003e6Test

المؤلفون: Filippo Nardone

المصدر: Nuova Antologia Militare, Vol 5, Iss 17, Pp 321-382 (2024)

مصطلحات موضوعية: History (General) and history of Europe, Military Science

الوصف: This article examines the historiographical interpretation of Italian infantries during the period from the 12th to the early 14th century by the prominent Italian polemologist Piero Pieri (1893-1979), whose work stands as the sole comprehensive analysis on this subject and has served as a major source of inspiration for subsequent scholars. However, given the passage of 90 years and the accumulation of new research, his work requires revision. Specifically, this article challenges Pieri’s rigid temporal and regional categorization, which separates a superior Lombard infantry of the Swabian era, characterized by militarized citizenry, from an inferior Tuscan infantry of the Late Communal period, characterized by bourgeois and peasant levies. This piece rejects Pieri’s criterion for assessing infantry quality in a decontextualized manner and highlights the remarkable homogeneity and excellence of Italian armies in the early 14th century. It asserts that these armies reflect a more cohesive and state-oriented Communal development compared to the more primitive system of the Swabian era. The article also explores the interregional similarity of Italian warfare through mercenarism and underscores the considerable superiority of Italian Communal armies over other European infantries in the early 14th century.

وصف الملف: electronic resource

العلاقة: https://www.tabedizioni.it/web/content/296916Test; https://doaj.org/toc/2704-9795Test

الوصول الحر: https://doaj.org/article/bc5d2986aead4ce5a80f3c7703d58e17Test

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المصدر: Lancet (London, England). 396(10261):1511-1524

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:145104614Test