المؤلفون: Hirofumi Nishizono, Ryohei Yasuda, Tal Laviv

المصدر: Frontiers in Genome Editing, Vol 2 (2020)

مصطلحات موضوعية: HITI (homology-independent targeted integration), SLENDR (single-cell labeling of endogenous proteins with homology-directed repair), iGONAD (improved-genome editing via oviductal nucleic acids delivery), HDR (homology-directed repair), NHEJ (non-homologous end joining), Biotechnology, TP248.13-248.65, Genetics, QH426-470

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fgeed.2020.602970/fullTest; https://doaj.org/toc/2673-3439Test

الوصول الحر: https://doaj.org/article/df1d0e499df242beaf2bf4a8aef2d69fTest

المؤلفون: Yuanjin Zhang, Yuanqing Guo, Yeye Xu, Jie Liu, Jian Lu, Xin Wang

المصدر: Acta Pharmaceutica Sinica B, Vol 11, Iss 10, Pp 2973-2982 (2021)
Acta Pharmaceutica Sinica. B

مصطلحات موضوعية: NCBI, National Center for Biotechnology Information, TALEN, transcriptional activators like effector nucleases, RNP, ribonucleoprotein, Review, Gene editing, SREBP-2, sterol regulatory element-binding protein 2, 0302 clinical medicine, AAV, adeno-associated virus, Genome editing, DDI, drug–drug interaction, CRISPR, General Pharmacology, Toxicology and Pharmaceutics, 0303 health sciences, HDR, homology directed repair, tracRNA, trans-activating crRNA, ADMET, absorption, distribution, metabolism, excretion and toxicity, HIV, human immunodeficiency virus, 030220 oncology & carcinogenesis, CRISPR-Cas9, OATP1B, organic anion transporting polypeptides 1B, Rat model, CRISPR-Cas, clustered regularly interspaced short palindromic repeats-CRISPR-associated, pre-crRNA, pre-CRISPR RNA, Computational biology, RM1-950, 03 medical and health sciences, Animal model, Pharmacokinetics, TALE, transcriptional activator-like effector, ZFN, zinc finger nucleases, DSB, double-strand break, PAM, protospacer-associated motif, Gene knockout, BSEP, bile salt export pump, 030304 developmental biology, Drug metabolism, KO, knockout, Mechanism (biology), sgRNA, single guide RNA, crRNAs, CRISPR RNAs, WT, wild-type, HBV, hepatitis B virus, T7E I, T7 endonuclease I, NHEJ, non-homologous end joining, SD, Sprague–Dawley, OTS, off-target site, DMPK, drug metabolism and pharmacokinetics, Therapeutics. Pharmacology, HPV, human papillomaviruses

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::953da916a138cd7d6b71c2e8c8f9668aTest
http://www.sciencedirect.com/science/article/pii/S2211383521000113Test

المؤلفون: Siyuan Chen, Xiawei Wei, Manni Wang, Yuquan Wei

المصدر: Acta Pharmaceutica Sinica. B
Acta Pharmaceutica Sinica B, Vol 11, Iss 12, Pp 3935-3949 (2021)

مصطلحات موضوعية: Senescence, Paclitaxel, DNA repair, NHEJ, non homologous end joining, medicine.medical_treatment, LCLC, large-cell carcinoma, RM1-950, Chemosensitization, DDR, DNA damage response, chemistry.chemical_compound, Non-small cell lung cancer, DNA-PK, DNA-dependent protein kinase, NSCLC, non-small cell lung cancer, medicine, Cytotoxic T cell, General Pharmacology, Toxicology and Pharmaceutics, Lung cancer, Adverse effect, DSB, DNA double-strand breaks, Etoposide, DNA-PKcs, DNA-dependent protein kinase catalytic subunit, Chemotherapy, business.industry, LADC, lung adenocarcinoma, medicine.disease, LSCC, lung squamous cell carcinoma, respiratory tract diseases, M3814, dsDNA, double strand DNA, chemistry, DNA-dependent protein kinase, Cancer research, Original Article, Cell senescence, Therapeutics. Pharmacology, HR, homologous recombination, business, IHC, immunohistochemistry, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48576014833ff0883918307b9873dc5eTest
http://europepmc.org/articles/PMC8727896Test

المؤلفون: Sheila Maestro, Gloria González-Aseguinolaza, Rafael Aldabe, Nicholas D. Weber, Nerea Zabaleta

المصدر: JHEP Reports

مصطلحات موضوعية: MPS type VII, MPSVII, S/MAR, scaffold matrix attachment regions, PB, piggyBac, gene addition, GalNAc, N-acetyl-D-galactosamine, UCD, urea cycle disorders, Genetic enhancement, medicine.medical_treatment, efficacy, MMA, methylmalonic acidemia, Review, Liver transplantation, medicine.disease_cause, MPS, mucopolysaccharidosis, immune response, IDS, iduronate 2-sulfatase, lncRNA, long non-coding RNA, gene silencing, GSD1a, glycogen storage disorder 1a, AAV, adeno-associated virus, ASOs, antisense oligonucleotides, Genome editing, AHP, acute hepatic porphyrias, HT, hereditary tyrosinemia, IMLD, inherited metabolic liver diseases, PFIC3, progressive familial cholestasis type 3, Immunology and Allergy, NHPs, non-human primates, CRISPR/Cas9, CRISPR associated protein 9, GO, glycolate oxidase, HemA/B, haemophilia A/B, Adeno-associated virus, HDR, homology-directed repair, Transcription activator-like effector nuclease, LNP, Lipid nanoparticles, siRNA, small-interfering RNA, MPR, metabolic pathway reprograming, LDH, lactate dehydrogenase, PH1, Primary hyperoxaluria type 1, gene editing, SRT, substrate reduction therapy, Gastroenterology, Ad, adenovirus, AAT, α1-antitrypsin, PA, propionic acidemia, dCas9, dead Cas9, ERT, enzyme replacement therapy, HDAd, helper-dependent adenovirus, CRISPR, clustered regularly interspaced short palindromic repeats, SB, Sleeping Beauty, LDLR, low-density lipoprotein receptor, MPS type I, MPSI, hepatocytes, OTC, ornithine transcarbamylase, APCs, antigen-presenting cells, DSBs, double-strand breaks, viral vectors, LV, lentivirus, AIP, acute intermittent porphyria, NASH, non-alcoholic steatohepatitis, GT, gene therapy, PKU, phenylketonuria, Computational biology, Gene delivery, Biology, FH, familial hypercholesterolemia, Viral vector, ITR, inverted terminal repetition, ZFN, zinc finger nucleases, GUSB, β-glucuronidase, Internal Medicine, medicine, OLT, orthotopic liver transplantation, Gene silencing, miRNAs, microRNAs, ASGPR, asialoglycoprotein receptor, ALAS1, aminolevulic synthase 1, TALEN, transcription activator-like effector nucleases, CBS, cystathionine β-synthase, PEG, polyethylene glycol, PEI, polyethyleneimine, TTR, transthyretin, Hepatology, IDUA, α-L-iduronidase, toxicity, ASGCT, American Society of Gene and Cell Therapy, CN, Crigel-Najjar, STK25, serine/threonine protein kinase 25, VLDLR, very-low-density lipoprotein receptor, WD, Wilson’s disease, FSP27, fat-specific protein 27, NHEJ, non-homologous end joining, Non-viral vectors, LTR, long terminal repeat, apoB/E, apolipoprotein B/E, RV, retrovirus, PCSK9, proprotein convertase subtilisin/kexin type 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69cc33bd8f559ae9ccb64e180a7a274aTest
http://europepmc.org/articles/PMC8203845Test

المؤلفون: Anja A. Kühl, Monique R. Bernsen, Winfried Brenner, M. Welzel, Richard P. Baum, Samantha Exner, Eva J. Koziolek, Jakob Albrecht, Dagmar Sedding, Patricia Grabowski, Christian Fischer, Fränze Schmidt, Teresa Hartung, Joost C. Haeck, Franziska Briest, Carsten Grötzinger

المساهمون: Radiology & Nuclear Medicine

المصدر: Neoplasia (New York, N.Y.)
BASE-Bielefeld Academic Search Engine
Neoplasia: An International Journal for Oncology Research, Vol 23, Iss 1, Pp 80-98 (2021)
Neoplasia (United States), 23(1), 80-98

مصطلحات موضوعية: Apoptosis, FOXO3a, forkheadbox protein O3a, d, day(s), Rb, retinoblastoma protein, Mice, 0302 clinical medicine, JC-1, 5,5′,6,6′-tetrachloro-1,1′,3,3′-tetraethylbenzimidazolcarbocyanine iodide, Molecular Targeted Therapy, BER, base excision repair, Bortezomib, IC50, dose of half-maximum inhibitory effect, Ga-68, Gallium-68, Drug Synergism, DSMZ, Deutsche Sammlung für Mikroorganismen und Zellen, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunohistochemistry, Neuroendocrine Tumors, G0/1/2 phase, gap phase 0/1/2, 030220 oncology & carcinogenesis, CAM, chorioallantoic membrane, (M)Bq, (Mega-)Becquerel, Original article, PRRT, peptide receptor radionuclide therapy, DNA damage, p70S6K, ribosomal protein S6 kinase, DNA repair, Antineoplastic Agents, NEN, neuroendocrine neoplasms, ERK, extracellular-signal-regulated kinase, lcsh:RC254-282, AP-sides, apurinic or apyrimidinic sites, M phase, mitosis phase, 03 medical and health sciences, SDG 3 - Good Health and Well-being, In vivo, i.v., intravenous, NER, nucleotide excision repair, GO, Gene Ontology, Humans, Combination therapy, FOXM1, forkheadbox protein M1, Cisplatin, G1/2/3, grade 1/2/3, Dose-Response Relationship, Drug, Proteasome inhibition, Cell Cycle Checkpoints, n, number, H2AX, histone H2AX, 030104 developmental biology, Proteasome, NHEJ, non-homologous end joining, g, gram, Proteasome inhibitor, HR, homologous recombination, 0301 basic medicine, Cancer Research, BRIP1, BRCA1 Interacting Protein C-Terminal Helicase 1, Chick Embryo, RPA, replication protein A, GEP-NEN, gastroenteropancreatic neuroendocrine neoplasms, SCLC, small cell lung cancer, Gene Regulatory Networks, TGF, transforming growth factor, HTCA, human tumor colony assay, Gastrointestinal Neoplasms, i.p., intraperitoneal, M, molar, Lu-177, Lutetium-177, Proteasome Inhibitors, F-18-FDG-PET, 2-deoxy-2-(F-18)fluoro-D-glucose positron emission tomography, SSTR2, somatostatin receptor 2, PI3K, phosphoinositide 3-kinase, medicine.drug, DDR, DNA damage repair, MMR, mismatch repair, SKP2, S-Phase Kinase Associated Protein 2, PARP1, poly(ADP-ribose) polymerase 1, (RT)-PCR, (real-time) polymerase chain reaction, BRCA1/2, breast cancer protein 1/2, ER, endoplasmic reticulum, ROS, reactive oxygen species, S phase, synthesis phase, Cell Line, Tumor, h, hour(s), medicine, Animals, TLS, translesion synthesis, Cell Proliferation, business.industry, DSB, double-strand breaks, PTEN, phosphatase and tensin homolog, CK2, casein kinase 2, Drug Resistance, Neoplasm, Radionuclide therapy, SSB, single-strand breaks, Cancer research, business, MRI, magnetic resonance imaging, DNA Damage, Peptide receptor radionuclide therapy (PRRT)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b0fcaaba5da9ca61e63d327232b0b4Test
http://www.scopus.com/inward/record.url?scp=85096683387&partnerID=8YFLogxKTest

المؤلفون: Ryohei Yasuda, Hirofumi Nishizono, Tal Laviv

المصدر: Frontiers in Genome Editing, Vol 2 (2020)
Frontiers in Genome Editing

مصطلحات موضوعية: 0301 basic medicine, lcsh:QH426-470, Transgene, lcsh:Biotechnology, Computational biology, Review, Biology, Synapse, 03 medical and health sciences, 0302 clinical medicine, Genome editing, lcsh:TP248.13-248.65, CRISPR, Genome Editing, HDR (homology-directed repair), Cas9, HITI (homology-independent targeted integration), Mammalian brain, lcsh:Genetics, 030104 developmental biology, NHEJ (non-homologous end joining), Cell bodies, SLENDR (single-cell labeling of endogenous proteins with homology-directed repair), 030217 neurology & neurosurgery, Function (biology), iGONAD (improved-genome editing via oviductal nucleic acids delivery)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::027c58a5665dd5ba08f49e23d2a47fe5Test
https://www.frontiersin.org/articles/10.3389/fgeed.2020.602970/fullTest

المؤلفون: Ronald Chalmers, Michael Tellier

المصدر: DNA Repair

مصطلحات موضوعية: DNA End-Joining Repair, DSB, DNA double-strand break, DNA Repair, DNA repair, Biology, medicine.disease_cause, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Plasmid, Protein Domains, Cell Line, Tumor, Transcriptional regulation, medicine, Humans, DNA Breaks, Double-Stranded, Metnase, DNA Integration, Molecular Biology, Gene, 030304 developmental biology, Genetics, 0303 health sciences, Mutation, SETMAR, DNA double-strand break repair, DNA, Histone-Lysine N-Methyltransferase, Cell Biology, Non-homologous end joining, DNA integration, chemistry, NHEJ, non-homologous end joining, 030220 oncology & carcinogenesis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccb42ee4bfe72e379a40f8def4c08a3cTest
http://ora.ox.ac.uk/objects/uuidTest:

المؤلفون: Kazlauskas, Darius, Sezonov, Guennadi, Charpin, Nicole, Venclovas, Česlovas, Forterre, Patrick, Krupovic, Mart

المساهمون: Vilnius University [Vilnius], Génomique et Génétique des thaumarchées (GGT), Evolution Paris Seine, Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS), Biologie Moléculaire du Gène chez les Extrêmophiles (BMGE), Institut Pasteur [Paris], Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles et de la Guyane (UAG)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Université Nice Sophia Antipolis (1965 - 2019) (UNS), Institut Pasteur [Paris] (IP)

المصدر: Journal of molecular biology, London : Academic Press Inc Elsevier science, 2018, Vol. 430, iss. 5, p. 737-750
Journal of Molecular Biology
Journal of Molecular Biology, Elsevier, 2018, 430 (5), pp.737-750. ⟨10.1016/j.jmb.2017.11.014⟩
Journal of Molecular Biology, 2018, 430 (5), pp.737-750. ⟨10.1016/j.jmb.2017.11.014⟩

مصطلحات موضوعية: DNA Replication, Models, Molecular, MGEs, mobile genetic elements, Protein Conformation, [SDV]Life Sciences [q-bio], DNA Primase, Article, Evolution, Molecular, Protein Domains, Catalytic Domain, evolution, AEPs, archaeo-eukaryotic primases, DUF, domain of unknown function, DNA primases, archaeo-eukaryotic primase (AEP), archaeal primase–polymerase PolpTN2, Amino Acid Sequence, Thermococcus plasmids, Bacteria, structural modeling, helicases, WH, winged-helix, DNA Helicases, Eukaryota, HTH, helix-turn-helix, PriCT-1/PriCT-2, Primase-C Terminal-1/2, Archaea, LigD, ligase D, Interspersed Repetitive Sequences, Thermococcus, NHEJ, non-homologous end joining, pVOG, prokaryotic virus orthologous groups, ZnBD, Zn-binding domain, Sequence Alignment

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1ef682c3b5fd4fd3c8f8443c35314d79Test
https://repository.vu.lt/VU:ELABAPDB25104523&prefLang=en_USTest

المؤلفون: Jochen Förster, Vratislav Stovicek, Irina Borodina

المصدر: Metabolic Engineering Communications
Stovicek, V, Borodina, I & Förster, J 2015, ' CRISPR–Cas system enables fast and simple genome editing of industrial Saccharomyces cerevisiae strains ', Metabolic Engineering Communications, vol. 2, pp. 13-22 . https://doi.org/10.1016/j.meteno.2015.03.001Test
Metabolic Engineering Communications, Vol 2, Iss, Pp 13-22 (2015)

مصطلحات موضوعية: lcsh:Biotechnology, Endocrinology, Diabetes and Metabolism, DSB, double strand break, Saccharomyces cerevisiae, CRISPR–Cas9, clustered regularly interspaced short palindromic repeats–CRISPR-associated endonuclease 9, Biomedical Engineering, CRISPR–Cas9, Article, PI, propidium iodide, USER, uracil-specific excision reaction, Genome editing, lcsh:TP248.13-248.65, PAM, protospacer adjacent motif, CRISPR, SDG 7 - Affordable and Clean Energy, lcsh:QH301-705.5, Gene, HDR, homology-directed repair, 2. Zero hunger, Genetics, Trans-activating crRNA, Transcription activator-like effector nuclease, Reporter gene, GOI, gene of interest, biology, tracrRNA, trans-activating RNA, crRNA, CRISPR RNA, biology.organism_classification, gRNA, guide RNA, Industrial yeast, TALENs, transcription activator-like effector nucleases, Transformation (genetics), Biorefineries, lcsh:Biology (General), NHEJ, non-homologous end joining, SNPs, single nucleotide polymorphisms, Chemical production, ZFNs, zinc finger nucleases, HR, homologous recombination

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab0c2c5cb8218a53d1eea2cd24a9e47Test
http://europepmc.org/articles/PMC8193243Test

المؤلفون: Sabine Schmitz, Yvonne Lorat, Nadine Schuler, Claudia E. Rübe, Jan Palm

المصدر: Clinical and translational radiation oncology 7, 71-78 (2017). doi:10.1016/j.ctro.2017.10.004
Clinical and Translational Radiation Oncology
Clinical and Translational Radiation Oncology, Vol 7, Iss, Pp 71-78 (2017)

مصطلحات موضوعية: 0301 basic medicine, Genome instability, Genomic instability, Pathology, medicine.medical_specialty, DNA repair, DNA damage, R895-920, Craniospinal Irradiation, Article, Medical physics. Medical radiology. Nuclear medicine, 03 medical and health sciences, Germline mutation, LFS, Li-Fraumeni syndrome, medicine, Radiology, Nuclear Medicine and imaging, SEM, scanning electron microscopy, Li-Fraumeni syndrome, ddc:610, TEM, transmission electron microscopy, DSBs, double-strands breaks, RC254-282, P53, business.industry, CPC, choroid plexus carcinoma, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Cancer, Craniospinal irradiation, medicine.disease, 53BP1, 53 Binding Protein 1, Hematopoiesis, NHEJ, non-homologous end-joining, γH2AX, phosporylated histone H2AX, 030104 developmental biology, medicine.anatomical_structure, Oncology, Li–Fraumeni syndrome, mFISH, multicolour fluorescence in-situ hybridization, Bone marrow, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03caa63d129c0cc1496a9436a5e3c549Test
https://juser.fz-juelich.de/record/839969Test