المؤلفون: Martins, Emily Souto, Oliveira, Eloiza Gonçalves Campos, Alves, Karyne Gabriele Leite, Oliveira, Lorenna Fonseca Braga de, Maia, Naiara Gonçalves Fonseca, Dias, Verônica Oliveira, Oliveira, Carolina de Castro, Oliveira, Maria José Lages de

المصدر: Pesquisa Brasileira em Odontopediatria e Clínica Integrada. January 2019 19

مصطلحات موضوعية: Patients, Child, Hospitalized, Health Education, Oral Health

الوصف: Objective: To evaluate the oral health conditions of hospitalized children, as well as describe the knowledge and practices of oral health care adopted by their parents/guardians. Material and Methods: The sample was composed of 46 children who had been hospitalized for at least five days, who had erupted teeth in the oral cavity and were accompanied by their parents/guardians. Information was collected in relation to: the oral health status of children (DMFT/DEF), the socioeconomic profile and access to information on health and oral hygiene of the parents/guardians and data regarding the hospitalization of the children. The data were analyzed using the Fisher, Pearson's and Mann Whitney's Chi-squared tests, with a confidence level of 95%. Results: 47.8% of the hospitalized children had experienced caries, and the most relevant component for the determination of the experience of caries was the presence of decayed teeth (0.50 to 1.94). A total of 97.8% of parents/guardians said they had not received information on oral health and hygiene, 100.0% had not received guidance on the sugar contained in medicines or the salivary decrease caused by the medications. 34.8% of the children did not perform oral hygiene during hospitalization. According to medical records, 58.7% took liquid medication orally. Conclusion: The hospitalized children had precarious oral health conditions, with the occurrence of carious lesions of the teeth. The presence of risk factors for dental caries in hospitalized children was observed (poor oral hygiene, low schooling and income of parents/guardians, limited knowledge of parents/guardians regarding health care and oral hygiene, consumption of medicines with cariogenic potential).

وصف الملف: text/html

الوصول الحر: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1983-46322019000100320Test

المؤلفون: Martins, Emilia Pereira.

الوصف: Thesis (Ph. D.)--University of Wisconsin--Madison, 1992.
Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

الإتاحة: http://catalog.hathitrust.org/api/volumes/oclc/28124452.htmlTest

المؤلفون: Bui-Nguyen, Tri M.¹, Pakala, Suresh B.¹, Sirigiri, Divijendranatha Reddy¹, Martins, Emil², Murad, Ferid², Kumar, Rakesh¹ bcmrxk@gwumc.edu

المصدر: Journal of Biological Chemistry. 3/5/2010, Vol. 285 Issue 10, p6980-6986. 7p.

مصطلحات موضوعية: *NITRIC oxide, *HEPATITIS B virus, *LIVER cancer, *LIVER cells, *NON-coding RNA, *NITRIC-oxide synthases, *CANCER cells, *NF-kappa B

مستخلص: Nitric oxide has been implicated in the pathogenesis of inflammatory disorders, including hepatitis B virus-associated hepatocellular carcinoma. Transactivator protein HBx, a major regulator of cellular responses of hepatitis B virus, is known to induce the expression of MTA1 (metastasis-associated protein 1) coregulator via NF-κB signaling in hepatic cells. However, the underlying mechanism of HBx regulation of the inducible nitric-oxide synthase (iNOS) pathway remains unknown. Here we provide evidence that MTA1 is a positive regulator of iNOS transcription and plays a mechanistic role in HBx stimulation of iNOS expression and activity. We found that the HBx-MTA1 complexisrecruitedontothe human iNOS promoterinan NF-κB-dependent manner. Pharmacological inhibition of the NF-κB signaling prevented the ability of HBx to stimulate the transcription, the expression, and the activity of iNOS; nevertheless, these effects could be substantially rescued by MTA1 dysregulation. We further discovered that HBx-mediated stimulation of MTA1 is paralleled by the suppression of miR-661, a member of the small noncoding RNAs, recently shown to target MTA1. We observed that miR-661 controls of MTA1 expression contributed to the expression and activity of iNOS in HBx-expressing HepG2 cells. Accordingly, depletion of MTA1 by either miR-661 or siRNA in HBx-expressing cells severely impaired the ability of HBx to modulate the endogenous levels of iNOS and nitrite production. Together, these findings reveal an inherent role of MTA1 in HBx regulation of iNOS expression and consequently its function in the liver cancer cells. [ABSTRACT FROM AUTHOR]

المؤلفون: Sanghani, Paresh C.¹ psanghan@iupui.edu, Davis, Wilhelmina I.¹, Fears, Sharry L.¹, Green, Scheri-Lyn¹, Zhai, Lanmin¹, Tang, Yaoping², Martins, Emil², Bryan, Nathan S.², Sanghani, Sonal P.¹

المصدر: Journal of Biological Chemistry. 9/4/2009, Vol. 284 Issue 36, p24354-24362. 9p. 2 Charts, 5 Graphs.

مصطلحات موضوعية: *BETA adrenoceptors, *ALCOHOL dehydrogenase, *BINDING sites, *NITRIC-oxide synthases, *NF-kappa B, *SMOOTH muscle physiology, *LABORATORY mice, *CELL physiology

مستخلص: S-Nitrosoglutathione reductase (GSNOR) is an alcohol dehydrogenase involved in the regulation of S-nitrosothiols (SNOs) in vivo. Knock-out studies in mice have shown that GSNOR regulates the smooth muscle tone in airways and the function of β-adrenergic receptors in lungs and heart. GSNOR has emerged as a target for the development of therapeutic approaches for treating lung and cardiovascular diseases. We report three compounds that exclude GSNOR substrate, S-nitrosoglutathione (GSNO) from its binding site in GSNOR and cause an accumulation of SNOs inside the cells. The new inhibitors selectively inhibit GSNOR among the alcohol dehydrogenases. Using the inhibitors, we demonstrate that GSNOR limits nitric oxide-mediated suppression of NF-KB and activation of soluble guanylyl cyclase. Our findings reveal GSNOR inhibitors to be novel tools for regulating nitric oxide bioactivity and assessing the role of SNOs in vivo. [ABSTRACT FROM AUTHOR]