المؤلفون: Vergaro, Giuseppe, Gentile, Francesco, Aimo, Alberto, Januzzi, James L., Richards, A. Mark, Lam, Carolyn S. P., Boer, Rudolf A., Meems, Laura M. G., Latini, Roberto, Staszewsky, Lidia, Anand, Inder S., Cohn, Jay N., Ueland, Thor, Gullestad, Lars, Aukrust, Pal, Rocca, Hans-Peter Brunner-La, Bayes-Genis, Antoni, Lupon, Josep, Yoshihisa, Akiomi, Takeishi, Yasuchika, Egstrup, Michael, Gustafsson, Ida, Gaggin, Hanna K., Eggers, Kai M., 1962, Huber, Kurt, Gamble, Greg D., Ling, Lieng H., Leong, Kui Toh Gerard, Yeo, Poh Shuah Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P., Troughton, Richard, Doughty, Robert N., Devlin, Gerry, Lund, Mayanna, Giannoni, Alberto, Passino, Claudio, Emdin, Michele

المصدر: ESC Heart Failure. 9(4):2084-2095

مصطلحات موضوعية: Chronic heart failure, Sex, Women, Prognosis, sST2, High-sensitivity troponin T, NT-proBNP

الوصف: Aims To define plasma concentrations, determinants, and optimal prognostic cut-offs of soluble suppression of tumorigenesis-2 (sST2), high-sensitivity cardiac troponin T (hs-cTnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in women and men with chronic heart failure (HF). Methods and results Individual data of patients from the Biomarkers In Heart Failure Outpatient Study (BIOS) Consortium with sST2, hs-cTnT, and NT-proBNP measured were analysed. The primary endpoint was a composite of 1 year cardiovascular death and HF hospitalization. The secondary endpoints were 5 year cardiovascular and all-cause death. The cohort included 4540 patients (age 67 +/- 12 years, left ventricular ejection fraction 33 +/- 13%, 1111 women, 25%). Women showed lower sST2 (24 vs. 27 ng/mL, P < 0.001) and hs-cTnT level (15 vs. 20 ng/L, P < 0.001), and similar concentrations of NT-proBNP (1540 vs. 1505 ng/L, P = 0.408). Although the three biomarkers were confirmed as independent predictors of outcome in both sexes, the optimal prognostic cut-off was lower in women for sST2 (28 vs. 31 ng/mL) and hs-cTnT (22 vs. 25 ng/L), while NT-proBNP cut-off was higher in women (2339 ng/L vs. 2145 ng/L). The use of sex-specific cut-offs improved risk prediction compared with the use of previously standardized prognostic cut-offs and allowed to reclassify the risk of many patients, to a greater extent in women than men, and for hs-cTnT than sST2 or NT-proBNP. Specifically, up to 18% men and up to 57% women were reclassified, by using the sex-specific cut-off of hs-cTnT for the endpoint of 5 year cardiovascular death. Conclusions In patients with chronic HF, concentrations of sST2 and hs-cTnT, but not of NT-proBNP, are lower in women. Lower sST2 and hs-cTnT and higher NT-proBNP cut-offs for risk stratification could be used in women.

وصف الملف: electronic

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-485911Test
https://doi.org/10.1002/ehf2.13883Test
https://uu.diva-portal.org/smash/get/diva2:1704299/FULLTEXT01.pdfTest

المؤلفون: Vergaro, Giuseppe, Aimo, Alberto, Januzzi, James L, Richards, A Mark, Lam, Carolyn S P, Latini, Roberto, Staszewsky, Lidia, Anand, Inder S, Ueland, Thor, Rocca, Hans-Peter Brunner-La, Bayes-Genis, Antoni, Lupón, Josep, de Boer, Rudolf A, Yoshihisa, Akiomi, Takeishi, Yasuchika, Gustafsson, Ida, Eggers, Kai M, Huber, Kurt, Gamble, Greg D, Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P, Troughton, Richard, Doughty, Robert N, Emdin, Michele, Passino, Claudio

المساهمون: Vergaro, Giuseppe, Aimo, Alberto, Januzzi, James L, Richards, A Mark, Lam, Carolyn S P, Latini, Roberto, Staszewsky, Lidia, Anand, Inder S, Ueland, Thor, Rocca, Hans-Peter Brunner-La, Bayes-Genis, Antoni, Lupón, Josep, de Boer, Rudolf A, Yoshihisa, Akiomi, Takeishi, Yasuchika, Gustafsson, Ida, Eggers, Kai M, Huber, Kurt, Gamble, Greg D, Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P, Troughton, Richard, Doughty, Robert N, Emdin, Michele, Passino, Claudio

الوصف: Aims: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2). Methods: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values. Results: Patients had a median age of 66 years (interquartile interval 57-74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487-2725), 17 ng/l (9-31) and 30 ng/ml (22-44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5-2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9-2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis. Conclusions: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.

العلاقة: volume:23; issue:1; firstpage:28; lastpage:36; numberofpages:9; journal:JOURNAL OF CARDIOVASCULAR MEDICINE; https://hdl.handle.net/11382/558880Test

الإتاحة: https://doi.org/10.2459/JCM.0000000000001281Test
https://hdl.handle.net/11382/558880Test

المؤلفون: Fitzsimons, Sarah, Yeo, Tee Joo, Ling, Lieng H., Sim, David, Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P., Poppe, Katrina, Lund, Mayanna, Devlin, Gerry, Troughton, Richard, Lam, Carolyn S.P., Richards, A. Mark, Doughty, Robert N.

المساهمون: Green Lane Research and Educational Fund

المصدر: ESC Heart Failure ; volume 8, issue 6, page 4572-4583 ; ISSN 2055-5822 2055-5822

الوصف: Aims The importance of iron deficiency (ID) in heart failure with preserved ejection fraction (HFpEF) is unknown. In HF with reduced ejection fraction (HFrEF), ID is reported as an independent predictor of mortality in HF although not all published studies agree. Different definitions of ID have been assessed, and the natural history of untreated ID not established, which may explain the conflicting results. This study aimed to assess the relationship between ID and mortality in HFpEF, clarify which definition of ID correlates best with outcomes in HFrEF, and determine the prognostic importance of change in ID status over time. Methods and results Analyses were conducted on data from 1563 patients participating in a prospective international cohort study comparing HFpEF with HFrEF. Plasma samples from baseline and 6 month visits were analysed for the presence of ID. Two ID definitions were evaluated: ID Ferritin = ‘ferritin < 100 mcg/L or ferritin 100–300 mcg/L + transferrin saturation < 20%’ and ID Tsat = ‘transferrin saturation < 20%’. The risk of all‐cause mortality and death/HF hospitalization associated with baseline ID (ID Ferritin or ID Tsat ) and change in ID status at 6 months (persistent, resolving, developing, or never present) was estimated in multivariable Cox proportional hazards models. Of 1563 patients, 1115 (71%) had HFrEF and 448 (29%) HFpEF. Prevalence of ID was similar in HFpEF and HFrEF (58%). Patients with ID were more likely to be female, diabetic, and have a higher co‐morbid burden than patients without ID. ID by either definition did not confer independent risk for either all‐cause mortality or death/HF hospitalization for patients with HFpEF [ID Ferritin hazard ratio (HR) 0.65 (95% confidence interval 0.40–1.05), P = 0.08; ID Tsat HR 1.16 (0.72–1.87), P = 0.55]. In the overall study cohort (HFrEF + HFpEF) and HFrEF subgroup, ID Ferritin was inferior to ID Tsat in prediction of all‐cause mortality [overall cohort: HR 1.21 (0.95–1.53), P = 0.12 vs. HR 1.95 (1.52–2.51), P ...

الإتاحة: https://doi.org/10.1002/ehf2.13617Test

المؤلفون: Gentile, Francesco, Aimo, Alberto, Jannuzzi, James Lj, Richards, Mark, Lam, Carolyn Sp, Boer, Rudolf A. De, Meems, Laura Mg, Latini, Roberto, Staszewsky, Lidia, Anand, Inder S., Cohn, Jay N., Ueland, Thor, Guellestad, Lars, Aukrust, Pal, Rocca, Hans-peter Brunner-la, Bayes-genis, Antoni, Lupon, Josep, Yoshihisa, Akiomi, Egstrup, Michael, Gustafsson, Ida, Gaggin, Hanna K., Eggers, Kai M., Huber, Kurt, Gamble, Greg D., Ling, Lieng H., Leong, Kui Toh Gerard, Yeo, Poh Shuah Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P., Troughton, Richard, Doughty, Robert N., Devlin, Gerry, Lund, Mayanna, Giannoni, Alberto, Passino, Claudio, Emdin, Michele, Vergaro, Giuseppe

المصدر: European Heart Journal Supplements ; volume 23, issue Supplement_G ; ISSN 1520-765X 1554-2815

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Aims Limited evidence exists on sex-related differences in clinical value of biomarkers in chronic heart failure (HF). We aimed to define plasma levels, determinants, and optimal prognostic cut-offs of soluble suppression of tumourigenesis-2 (sST2), high-sensitivity troponin T (hs-TnT), and N-terminal pro-B-type natriuretic peptide (NT-proBNP) in female and male chronic HF patients. Methods and results Individual data of patients from the BIOS (Biomarkers In Heart Failure Outpatient Study) Consortium with sST2, hs-TnT, and NT-proBNP measured were analysed. The primary endpoint was a composite of 1-year cardiovascular death and HF hospitalization. The secondary endpoints were 5-year cardiovascular and all-cause death. The cohort included 4540 patients (age: 67 ± 12 years, LVEF 33 ± 13%, 1111 women, 25%). Women showed lower sST2 (24 vs. 27 ng/ml, P < 0.001) and hs-TnT level (15 vs. 20 ng/l, P < 0.001), and similar concentrations of NT-proBNP (1540 vs. 1505 ng/l, P = 0.408). Although the three biomarkers were confirmed as independent predictors of outcome in both sexes, the optimal prognostic cut-off was lower in women for sST2 (28 vs. 31 ng/ml) and hs-TnT (22 vs. 25 ng/l), while NT-proBNP cut-off was higher in women (2339 ng/l vs. 2145 ng/l). The use of sex-specific cut-offs improved risk prediction compared to the use of previously standardized prognostic cut-offs (Figure). Conclusions In patients with chronic HF, levels of sST2 and hs-TnT, but not of NT-proBNP are lower in women. Lower sST2 and hs-TnT and higher NT-proBNP cut-offs for risk stratification could be used in women.

الإتاحة: https://doi.org/10.1093/eurheartj/suab139.017Test
https://academic.oup.com/eurheartjsupp/article-pdf/23/Supplement_G/suab139.017/41683679/suab139.017.pdfTest

المؤلفون: Ouwerkerk, Wouter, Tromp, Jasper, Jin, Xuanyi, Jaufeerally, Fazlur, Yeo, Poh Shuan Daniel, Leong, Kui Toh Gerard, Ong, Hean Yee, Ling, Lieng Hsi, Loh, Seet Yoong, Sim, David, Lee, Sheldon, Soon, Dinna, Chin, Calvin, Richards, A. Mark, Lam, Carolyn S. P.

المصدر: Ouwerkerk , W , Tromp , J , Jin , X , Jaufeerally , F , Yeo , P S D , Leong , K T G , Ong , H Y , Ling , L H , Loh , S Y , Sim , D , Lee , S , Soon , D , Chin , C , Richards , A M & Lam , C S P 2020 , ' Heart failure with preserved ejection fraction diagnostic scores in an Asian population ' , European Journal of Heart Failure , vol. 22 , no. 9 , pp. ....

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/60f6d8b4-f2a6-4f3e-a3b9-23e04dd24c06Test

الإتاحة: https://doi.org/10.1002/ejhf.1851Test
https://hdl.handle.net/11370/60f6d8b4-f2a6-4f3e-a3b9-23e04dd24c06Test
https://research.rug.nl/en/publications/60f6d8b4-f2a6-4f3e-a3b9-23e04dd24c06Test
https://pure.rug.nl/ws/files/150805431/ejhf.1851.pdfTest

المؤلفون: Tan, Eugene S. J., Tay, Wan Ting, Teng, Tiew-Hwa Katherine, Sim, David, Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze Pin, Poppe, Katrina, Lund, Mayanna, Devlin, Gerard, Troughton, Richard W., Ling, Lieng Hsi, Richards, Arthur Mark, Doughty, Robert N., Lam, Carolyn S. P.

المصدر: Tan , E S J , Tay , W T , Teng , T-H K , Sim , D , Leong , K T G , Yeo , P S D , Ong , H Y , Jaufeerally , F , Ng , T P , Poppe , K , Lund , M , Devlin , G , Troughton , R W , Ling , L H , Richards , A M , Doughty , R N & Lam , C S P 2019 , ' Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific ' ....

مصطلحات موضوعية: RISK-FACTORS, DIABETES-MELLITUS, POPULATION, PREVALENCE, COMMUNITY, MORTALITY, FRACTION, OUTCOMES, TRENDS, COHORT

الوصف: Objective Ethnic differences in the prevalence of atrial fibrillation (AF) in heart failure (HF) remain unclear. We compared the prevalence and clinical correlates of AF among different ethnicities in an Asian-Pacific population with HF. Methods Patients with validated HF were prospectively studied across Singapore and New Zealand (NZ). Results Among 1746 patients with HF (62% Asian, 26% women, mean age 66 (SD 13) years, mean ejection fraction (EF) 37 (SD 16%), 39% had AF. The prevalence of AF was markedly lower in Singapore-Asians than NZ-Europeans (24% vs 63%; p \Conclusion There is a strikingly lower prevalence of AF among Asian compared with NZ-European patients with HF. The underlying mechanisms for the lower prevalence of AF among Asians, particularly in the presence of diabetes, deserve further study.

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/3296fca5-9fd8-44c1-9d25-60ae986ce13dTest

الإتاحة: https://doi.org/10.1136/heartjnl-2018-314077Test
https://hdl.handle.net/11370/3296fca5-9fd8-44c1-9d25-60ae986ce13dTest
https://research.rug.nl/en/publications/3296fca5-9fd8-44c1-9d25-60ae986ce13dTest
https://pure.rug.nl/ws/files/93531938/842.full.pdfTest

المؤلفون: Tan, Eugene SJ, Chan, Siew Pang, Xu, Chang Fen, Yap, Jonathan, Richards, Arthur Mark, Ling, Lieng Hsi, Sim, David, Jaufeerally, Fazlur, Yeo, Daniel, Loh, Seet Yoong, Ong, Hean Yee, Leong, Kui Toh Gerard, Ng, Tze Pin, Nyunt, Shwe Zin, Feng, Liang, Okin, Peter, Lam, Carolyn SP, Lim, Toon Wei

المساهمون: National Medical Research Council, Health Services Research programme, A*STAR-NZ HRC, Clinician Scientist Award

المصدر: Heart Asia ; volume 11, issue 1, page e011108 ; ISSN 1759-1104

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الوصف: Objective ECG markers of heart failure (HF) with preserved ejection fraction (HFpEF) are lacking. We hypothesised that the Cornell product (CP) is a risk marker of HFpEF and has prognostic utility in HFpEF. Methods CP =[(amplitude of R wave in aVL+depth of S wave in V3)×QRS] was measured on baseline 12-lead ECG in a prospective Asian population-based study of 606 healthy controls (aged 55±10 years, 45% men), 221 hypertensive controls (62±9 years, 58% men) and 242 HFpEF (68±12 years, 49% men); all with EF ≥50% and followed for 2 years for all-cause mortality and HF hospitalisations. Results CP increased across groups from healthy controls to hypertensive controls to HFpEF, and distinguished between HFpEF and hypertension with an optimal cut-off of ≥1800 mm*ms (sensitivity 40%, specificity 85%). Age, male sex, systolic blood pressure (SBP) and heart rate were independent predictors of CP ≥1800 mm*ms, and CP was associated with echocardiographic E/e′ (r=0.27, p<0.01) and left ventricular mass index (r=0.46, p<0.01). Adjusting for clinical and echocardiographic variables and log N-terminal pro B-type natriuretic peptide (NT-proBNP), CP ≥1800 mm*ms was significantly associated with HFpEF (adjusted OR 2.7, 95% CI 1.0 to 7.0). At 2-year follow-up, there were 29 deaths and 61 HF hospitalisations, all within the HFpEF group. Even after adjusting for log NT-proBNP, clinical and echocardiographic variables, CP ≥1800 mm*ms remained strongly associated with a higher composite endpoint of all-cause mortality and HF hospitalisations (adjusted HR 2.1, 95% CI 1.2 to 3.5). Conclusion The Cornell product is an easily applicable ECG marker of HFpEF and predicts poor prognosis by reflecting the severity of diastolic dysfunction and LV hypertrophy.

الإتاحة: https://doi.org/10.1136/heartasia-2018-011108Test

المؤلفون: Vergaro, Giuseppe, Aimo, Alberto, Januzzi, James L., Richards, A. Mark, Lam, Carolyn S.P., Latini, Roberto, Staszewsky, Lidia, Anand, Inder S., Ueland, Thor, Brunner-La Rocca, Hans-Peter, Bayes-Genis, Antoni, Lupón, Josep, de Boer, Rudolf A., Yoshihisa, Akiomi, Takeishi, Yasuchika, Gustafsson, Ida, Eggers, Kai M., 1962, Huber, Kurt, Gamble, Greg D., Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P., Troughton, Richard, Doughty, Robert N., Emdin, Michele, Passino, Claudio

المصدر: Journal of Cardiovascular Medicine. 23(1):28-36

الوصف: Aim: Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2).Methods: Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8088) were analysed. A subgroup (n = 3414) had also sST2 values.Results: Patients had a median age of 66 years (interquartile interval 57–74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487–2725), 17 ng/l (9–31) and 30 ng/ml (22–44), respectively. Patients with COPD (n = 1249, 15%) had higher NT-proBNP (P = 0.042) and hs-TnT (P < 0.001), but not sST2 (P = 0.165). Over a median 2.0-year follow-up (1.5–2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9–2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis.Conclusions: Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status.

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-489752Test

المؤلفون: Lam, Carolyn S P, Gamble, Greg D, Ling, Lieng H, Sim, David, Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P, Cameron, Vicky A, Poppe, Katrina, Lund, Mayanna, Devlin, Gerry, Troughton, Richard, Richards, A Mark, Doughty, Robert N

المساهمون: National Medical Research Council

المصدر: European Heart Journal ; volume 39, issue 20, page 1770-1780 ; ISSN 0195-668X 1522-9645

الإتاحة: https://doi.org/10.1093/eurheartj/ehy005Test
http://academic.oup.com/eurheartj/article-pdf/39/20/1770/24836608/ehy005.pdfTest

المؤلفون: Bosch, Lena, Lam, Carolyn S.P., Gong, Lingli, Chan, Siew Pang, Sim, David, Yeo, Daniel, Jaufeerally, Fazlur, Leong, Kui Toh Gerard, Ong, Hean Yee, Ng, Tze Pin, Richards, Arthur Mark, Arslan, Fatih, Ling, Lieng H.

المساهمون: Universitair Medisch Centrum Utrecht, Boston Scientific Corporation, Bayer, Medtronic, Vifor Pharma, Novartis, Merck, Janssen Research and Development, Pfizer, Alere

المصدر: European Journal of Heart Failure ; volume 19, issue 12, page 1664-1671 ; ISSN 1388-9842 1879-0844

الوصف: Background Right ventricular ( RV ) dysfunction is recognized as a major prognostic factor in left‐sided heart failure ( HF ). However, the relative contribution of RV dysfunction in HF with preserved ( HFpEF ) vs. reduced ejection fraction ( HFrEF ) is unclear. Methods and results Right ventricular longitudinal strain ( RVLS ), tricuspid annular plane systolic excursion ( TAPSE ) and pulmonary artery systolic pressure ( PASP ) were determined by echocardiography in 657 age‐ and gender‐matched groups of patients with HFpEF [left ventricular ejection fraction ( LVEF ) ≥50%; n =219] and HFrEF ( LVEF <50%; n =219) and in controls without HF ( n =219) from an Asian population‐based cohort study. Across control to HFpEF and HFrEF groups, RV function deteriorated as measured by RVLS (−26.7 ± 5%, −22.7±6.6% and −18.2 ± 6.7%, respectively) and TAPSE (21.0 ± 3.9, 17.5 ± 5.1 and 14.7 ± 4.7 mm, respectively), whereas PASP increased (26.8 ± 7.1, 34.5 ± 11.9 and 39.3 ± 16.2 mmHg , respectively) (all P <0.001). Controlling for PASP in control, HFpEF and HFrEF subjects, the magnitude of RVLS / PASP (−1.06 ± 0.32, −0.75 ± 0.32 and −0.56 ± 0.36, respectively) and TAPSE / PASP ratios (0.83 ± 0.23, 0.54 ± 0.24 and 0.55 ± 0.29, respectively) similarly decreased across groups. Right ventricular dysfunction (by both TAPSE and RVLS ) was independently associated with left ventricular systolic dysfunction and atrial fibrillation, but not with PASP . Among patients with HF , both TAPSE / PASP and RVLS / PASP ratios were related to the composite endpoint of all‐cause death and HF hospitalization, even after multivariable adjustment [hazard ratio ( HR ) 0.33; 95% confidence interval ( CI ) 0.14–0.74 and HR 3.09; 95% CI 1.52–6.26, respectively], with no difference between HFrEF and HFpEF . Conclusions Right ventricular dysfunction is present in HFpEF and is even more pronounced in HFrEF for any given degree of pulmonary hypertension. It is independently predicted by left ventricular dysfunction but not by PASP . Right ...

الإتاحة: https://doi.org/10.1002/ejhf.873Test