المؤلفون: Sun, Yuming, Kang, Jian, Haridas, Chinmay, Mayne, Nicholas, Potter, Alexandra, Yang, Chi-Fu, Christiani, David C, Li, Yi

المساهمون: NIH

المصدر: Biometrics ; volume 80, issue 1 ; ISSN 0006-341X 1541-0420

مصطلحات موضوعية: Applied Mathematics, General Agricultural and Biological Sciences, General Immunology and Microbiology, General Biochemistry, Genetics and Molecular Biology, General Medicine, Statistics and Probability

الوصف: Lung cancer is a leading cause of cancer mortality globally, highlighting the importance of understanding its mortality risks to design effective patient-centered therapies. The National Lung Screening Trial (NLST) employed computed tomography texture analysis, which provides objective measurements of texture patterns on CT scans, to quantify the mortality risks of lung cancer patients. Partially linear Cox models have gained popularity for survival analysis by dissecting the hazard function into parametric and nonparametric components, allowing for the effective incorporation of both well-established risk factors (such as age and clinical variables) and emerging risk factors (eg, image features) within a unified framework. However, when the dimension of parametric components exceeds the sample size, the task of model fitting becomes formidable, while nonparametric modeling grapples with the curse of dimensionality. We propose a novel Penalized Deep Partially Linear Cox Model (Penalized DPLC), which incorporates the smoothly clipped absolute deviation (SCAD) penalty to select important texture features and employs a deep neural network to estimate the nonparametric component of the model. We prove the convergence and asymptotic properties of the estimator and compare it to other methods through extensive simulation studies, evaluating its performance in risk prediction and feature selection. The proposed method is applied to the NLST study dataset to uncover the effects of key clinical and imaging risk factors on patients’ survival. Our findings provide valuable insights into the relationship between these factors and survival outcomes.

الإتاحة: https://doi.org/10.1093/biomtc/ujad024Test
https://academic.oup.com/biometrics/article-pdf/80/1/ujad024/56764127/ujad024.pdfTest

المؤلفون: Potter, Alexandra L., Senthil, Priyanka, Keshwani, Alisha, McCleery, Spencer, Haridas, Chinmay, Kumar, Arvind, Mathey-Andrews, Camille, Martin, Linda W., Yang, Chi-Fu Jeffrey

المصدر: The Annals of Thoracic Surgery ; volume 117, issue 4, page 734-742 ; ISSN 0003-4975

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.athoracsur.2023.12.011Test
https://api.elsevier.com/content/article/PII:S0003497524000043?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0003497524000043?httpAccept=text/plainTest

المؤلفون: Potter, Alexandra L, Senthil, Priyanka, Srinivasan, Deepti, Raman, Vignesh, Kumar, Arvind, Haridas, Chinmay, Mathey-Andrews, Camille, Zheng, Wei, Jeffrey Yang, Chi-Fu

المصدر: J Thorac Cardiovasc Surg ; ISSN:1097-685X ; Volume:168 ; Issue:1

مصطلحات موضوعية: NCCN, USPSTF, cancer screening eligibility, computed tomography, disparities, early detection, lung cancer screening

الوصف: To evaluate race- and sex-based disparities in lung cancer screening eligibility under the 2013 US Preventive Services Task Force, 2021 US Preventive Services Task Force, and National Comprehensive Cancer Network lung cancer screening guidelines.

العلاقة: https://doi.org/10.1016/j.jtcvs.2023.10.025Test; https://pubmed.ncbi.nlm.nih.gov/37863179Test

الإتاحة: https://doi.org/10.1016/j.jtcvs.2023.10.025Test
https://pubmed.ncbi.nlm.nih.gov/37863179Test

المؤلفون: Potter, Alexandra L., Costantino, Christina L., Suliman, Raiya A., Haridas, Chinmay S., Senthil, Priyanka, Kumar, Arvind, Mayne, Nicholas R., Panda, Nikhil, Martin, Linda W., Yang, Chi-Fu Jeffrey

المصدر: Annals of Thoracic Surgery; Oct2023, Vol. 116 Issue 4, p684-692, 9p

مستخلص: The objective of this study was to evaluate patterns, predictors, and long-term outcomes of recurrent disease after complete resection for early-stage non-small cell lung cancer (NSCLC) using the National Lung Screening Trial (NLST). The frequency of recurrence in patients with pathologic stage I-II NSCLC who underwent complete resection (lobectomy or bilobectomy) in the NLST was evaluated. Predictors of increased risk of recurrence were assessed by Fine-Gray competing risks regression. Of the 497 patients meeting study inclusion criteria, 94 experienced a recurrence—a rate of 4.9 (95% CI, 4.0-6.0) per 100 person-years. The 5-year cumulative incidence of recurrence was 20.1% (95% CI, 16.5%-23.9%). Most patients experienced recurrences at distant sites alone (n = 47 [50.0%]) or at both locoregional and distant sites (n = 30 [31.9%]). The median time from resection to recurrence was 18.8 (10.6-30.7) months. The incidence rate of recurrence was significantly lower among patients with lung cancer detected by low-dose computed tomography screening during one of the three screening rounds of the NLST when compared with patients with lung cancer detected by chest radiography screening and patients with lung cancer not detected by any form of screening (ie, those diagnosed after a negative or missed screening exam and those diagnosed during follow-up after the three screening rounds of the NLST were completed) (P <.001). Median survival (from the date of recurrence) of patients with pathologic stage I and stage II disease who had recurrences at locoregional, distant, or both sites was 63.0, 23.1, and 9.8 months and 28.9, 8.7, and 10.2 months, respectively. In this analysis of NLST participants with completely resected stage I-II NSCLC, the 5-year cumulative incidence of recurrence was 20%. Nearly 82% of recurrences were at distant sites and associated with poor survival. [ABSTRACT FROM AUTHOR]

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المؤلفون: Sun, Yuming, Kang, Jian, Haridas, Chinmay, Mayne, Nicholas R., Potter, Alexandra L., Yang, Chi-Fu Jeffrey, Christiani, David C., Li, Yi

مصطلحات موضوعية: FOS: Computer and information sciences, Computer Science - Machine Learning, Statistics - Machine Learning, Image and Video Processing (eess.IV), FOS: Electrical engineering, electronic engineering, information engineering, Machine Learning (stat.ML), Electrical Engineering and Systems Science - Image and Video Processing, Machine Learning (cs.LG)

الوصف: Lung cancer is a leading cause of cancer mortality globally, highlighting the importance of understanding its mortality risks to design effective patient-centered therapies. The National Lung Screening Trial (NLST) was a nationwide study aimed at investigating risk factors for lung cancer. The study employed computed tomography texture analysis (CTTA), which provides objective measurements of texture patterns on CT scans, to quantify the mortality risks of lung cancer patients. Partially linear Cox models are becoming a popular tool for modeling survival outcomes, as they effectively handle both established risk factors (such as age and other clinical factors) and new risk factors (such as image features) in a single framework. The challenge in identifying the texture features that impact cancer survival is due to their sensitivity to factors such as scanner type, segmentation, and organ motion. To overcome this challenge, we propose a novel Penalized Deep Partially Linear Cox Model (Penalized DPLC), which incorporates the SCAD penalty to select significant texture features and employs a deep neural network to estimate the nonparametric component of the model accurately. We prove the convergence and asymptotic properties of the estimator and compare it to other methods through extensive simulation studies, evaluating its performance in risk prediction and feature selection. The proposed method is applied to the NLST study dataset to uncover the effects of key clinical and imaging risk factors on patients' survival. Our findings provide valuable insights into the relationship between these factors and survival outcomes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21d89597a133e785ddfc6282671aa1f0Test
http://arxiv.org/abs/2303.05341Test

المؤلفون: Potter, Alexandra L., Senthil, Priyanka, Srinivasan, Deepti, Raman, Vignesh, Kumar, Arvind, Haridas, Chinmay, Mathey-Andrews, Camille, Zheng, Wei, Jeffrey Yang, Chi-Fu

المساهمون: National Institutes of Health, National Cancer Institute, Vanderbilt-Ingram Cancer Center

المصدر: The Journal of Thoracic and Cardiovascular Surgery ; ISSN 0022-5223

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Pulmonary and Respiratory Medicine, Surgery

الإتاحة: https://doi.org/10.1016/j.jtcvs.2023.10.025Test
https://api.elsevier.com/content/article/PII:S0022522323009819?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0022522323009819?httpAccept=text/plainTest

المؤلفون: Potter, Alexandra L., Haridas, Chinmay, Neumann, Krista, Kiang, Mathew V., Fong, Zhi Ven, Riddell, Corinne A., Pope, Harrison G., Yang, Chi-Fu Jeffrey

المصدر: JAMA Oncology ; volume 9, issue 3, page 308 ; ISSN 2374-2437

الوصف: Importance The risk and timing of suicide among patients who undergo surgery for cancer remain largely unknown, and, to our knowledge, there are currently no organized programs in place to implement regular suicide screening among this patient population. Objective To evaluate the incidence, timing, and factors associated with suicide among patients undergoing cancer operations. Design, Setting, and Participants This retrospective population-based cohort study used data from the Surveillance, Epidemiology, and End Results Program database to examine the incidence of suicide, compared with the general US population, and timing of suicide among patients undergoing surgery for the 15 deadliest cancers in the US from 2000 to 2016. A Fine-Gray competing risks regression model was used to identify factors associated with an increased risk of suicide among patients in the cohort. Data were analyzed from September 2021 to January 2022. Exposures Surgery for cancer. Main Outcomes and Measures Incidence, compared with the general US population, timing, and factors associated with suicide after surgery for cancer. Results From 2000 to 2016, 1 811 397 patients (74.4% female; median [IQR] age, 62.0 [52.0-72.0] years) met study inclusion criteria. Of these patients, 1494 (0.08%) committed suicide after undergoing surgery for cancer. The incidence of suicide, compared with the general US population, was statistically significantly higher among patients undergoing surgery for cancers of the larynx (standardized mortality ratio [SMR], 4.02; 95% CI, 2.67-5.81), oral cavity and pharynx (SMR, 2.43; 95% CI, 1.93-3.03), esophagus (SMR, 2.25; 95% CI, 1.43-3.38), bladder (SMR, 2.09; 95% CI, 1.53-2.78), pancreas (SMR, 2.08; 95% CI, 1.29-3.19), lung (SMR, 1.73; 95% CI, 1.47-2.02), stomach (SMR, 1.70; 95% CI, 1.22-2.31), ovary (SMR, 1.64; 95% CI, 1.13-2.31), brain (SMR, 1.61; 95% CI, 1.12-2.26), and colon and rectum (SMR, 1.28; 95% CI, 1.16-1.40). Approximately 3%, 21%, and 50% of suicides were committed within the first month, first ...

الإتاحة: https://doi.org/10.1001/jamaoncol.2022.6549Test
https://jamanetwork.com/journals/jamaoncology/articlepdf/2800542/jamaoncology_potter_2023_oi_220085_1678387717.58668.pdfTest

المؤلفون: Potter, Alexandra L., Haridas, Chinmay, Yang, Chi-Fu Jeffrey

المصدر: JAMA Oncology ; volume 9, issue 11, page 1585 ; ISSN 2374-2437

الإتاحة: https://doi.org/10.1001/jamaoncol.2023.2594Test
https://jamanetwork.com/journals/jamaoncology/articlepdf/2810009/jamaoncology_potter_2023_lr_230018_1699901608.28953.pdfTest

المؤلفون: Hurd, Jacob, Haridas, Chinmay, Potter, Alexandra, Baiu, Ioana, Beqari, Jorind, Deng, John, Liou, Douglas, Patel, Deven, Yang, Chi-Fu Jeffrey

المصدر: European Journal of Cardio-Thoracic Surgery ; volume 62, issue 3 ; ISSN 1010-7940 1873-734X

الوصف: OBJECTIVES The oncological efficacy of minimally invasive thymectomy for thymic carcinoma is not well characterized. We compared overall survival and short-term outcomes between open and minimally invasive surgical (video-assisted thoracoscopic and robotic) approaches using the National Cancer Database. METHODS Perioperative outcomes and overall survival of patients who underwent open versus minimally invasive thymectomy for Masaoka stage I–III thymic carcinoma from 2010 to 2015 in the National Cancer Database were evaluated using propensity score-matched analysis and multivariable Cox proportional hazards modelling. Outcomes by surgical approach were assessed using an intent-to-treat analysis. RESULTS Of the 216 thymectomies that were evaluated, 43 (20%) were performed with minimally invasive techniques (22 video-assisted thoracoscopic and 21 robotic). The minimally invasive approach was associated with a shorter median length of stay when compared to the open approach (3 vs 5 days, P < 0.001). In the propensity score-matched analysis of 30 open and 30 minimally invasive thymectomies, the minimally invasive group did not differ significantly in median length of stay (3 vs 4.5 days, P = 0.27), 30-day readmission (P = 0.13), 30-day mortality (P = 0.60), 90-day mortality (P = 0.60), margin positivity (P = 0.39) and 5-year survival (78.6% vs 54.6%, P = 0.15) when compared to the open group. CONCLUSIONS In this national analysis, minimally invasive thymectomy for stage I–III thymic carcinoma was found to have no significant differences in short-term outcomes and overall survival when compared to open thymectomy.

الإتاحة: https://doi.org/10.1093/ejcts/ezac159Test
https://academic.oup.com/ejcts/article-pdf/62/3/ezac159/45611859/ezac159.pdfTest

المؤلفون: Hurd, Jacob¹ (AUTHOR) jchurd@mgh.harvard.edu, Haridas, Chinmay¹ (AUTHOR), Potter, Alexandra¹ (AUTHOR), Baiu, Ioana² (AUTHOR), Beqari, Jorind¹ (AUTHOR), Deng, John³ (AUTHOR), Liou, Douglas² (AUTHOR), Patel, Deven⁴ (AUTHOR), Yang, Chi-Fu Jeffrey¹ (AUTHOR)

المصدر: European Journal of Cardio-Thoracic Surgery. Sep2022, Vol. 62 Issue 3, p1-9. 9p.

مصطلحات موضوعية: *THYMECTOMY, *PROPORTIONAL hazards models, *SURVIVAL rate, *OVERALL survival, *CARCINOMA

مستخلص: Open in new tab Download slide OBJECTIVES The oncological efficacy of minimally invasive thymectomy for thymic carcinoma is not well characterized. We compared overall survival and short-term outcomes between open and minimally invasive surgical (video-assisted thoracoscopic and robotic) approaches using the National Cancer Database. METHODS Perioperative outcomes and overall survival of patients who underwent open versus minimally invasive thymectomy for Masaoka stage I–III thymic carcinoma from 2010 to 2015 in the National Cancer Database were evaluated using propensity score-matched analysis and multivariable Cox proportional hazards modelling. Outcomes by surgical approach were assessed using an intent-to-treat analysis. RESULTS Of the 216 thymectomies that were evaluated, 43 (20%) were performed with minimally invasive techniques (22 video-assisted thoracoscopic and 21 robotic). The minimally invasive approach was associated with a shorter median length of stay when compared to the open approach (3 vs 5 days, P < 0.001). In the propensity score-matched analysis of 30 open and 30 minimally invasive thymectomies, the minimally invasive group did not differ significantly in median length of stay (3 vs 4.5 days, P = 0.27), 30-day readmission (P = 0.13), 30-day mortality (P = 0.60), 90-day mortality (P = 0.60), margin positivity (P = 0.39) and 5-year survival (78.6% vs 54.6%, P = 0.15) when compared to the open group. CONCLUSIONS In this national analysis, minimally invasive thymectomy for stage I–III thymic carcinoma was found to have no significant differences in short-term outcomes and overall survival when compared to open thymectomy. [ABSTRACT FROM AUTHOR]