دورية أكاديمية
Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report
| العنوان: | Autoimmune pulmonary alveolar proteinosis during the treatment of nonspecific interstitial pneumonia complicated by clinically amyopathic dermatomyositis: A case report |
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| المؤلفون: | Naoko Arakawa, Yuno Shiota, Fumi Onizawa, Fumi Miyata, Azusa Miyoshi, Tomohiro Akaba, Mayoko Tsuji, Ken Arimura, Osamitsu Yagi, Mitsuko Kondo, Hideki Katsura, Etsuko Tagaya |
| المصدر: | Respirology Case Reports, Vol 12, Iss 6, Pp n/a-n/a (2024) |
| بيانات النشر: | Wiley, 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Diseases of the respiratory system |
| مصطلحات موضوعية: | autoimmune pulmonary alveolar proteinosis, clinically amyopathic dermatomyositis, immunosuppressive therapy, nonspecific interstitial pneumonia, Diseases of the respiratory system, RC705-779 |
| الوصف: | Abstract A 46‐year‐old male was treated with corticosteroids for nonspecific interstitial pneumonia (NSIP). He was referred to our hospital and admitted for worsening dyspnea and diffuse ground‐glass opacity on chest computed tomography (CT) during corticosteroid treatment. Gottron's sign was observed, and the patient was diagnosed with clinically amyopathic dermatomyositis on skin biopsy. We increased the corticosteroid dose and added immunosuppressive agents; however, the opacity on the chest CT worsened. Based on periodic‐acid‐Schiff‐positive granular material in the bronchoalveolar lavage fluid and the presence of anti‐GM‐CSF antibodies, the patient was diagnosed with autoimmune pulmonary alveolar proteinosis (APAP). The concentration of anti‐GM‐CSF antibodies in preserved serum was also elevated when the patient was diagnosed with NSIP. Thus, we assumed that NSIP and APAP coexisted, and that APAP manifested during immunosuppressive therapy. When exacerbation is observed during the treatment of interstitial pneumonia with immunosuppressive agents, it is necessary to consider APAP. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2051-3380 77756371 |
| العلاقة: | https://doaj.org/toc/2051-3380Test |
| DOI: | 10.1002/rcr2.1403 |
| الوصول الحر: | https://doaj.org/article/fb7a3d654b0145849fb1cf777563714aTest |
| رقم الانضمام: | edsdoj.fb7a3d654b0145849fb1cf777563714a |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 20513380 77756371 |
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| DOI: | 10.1002/rcr2.1403 |