المؤلفون: Hafez, G, Malyszko, J, Golenia, A, Klimkowicz-Mrowiec, A, Ferreira, AC, Arici, M, Bruchfeld, A, Nitsch, D, Massy, ZA, Pepin, M, Capasso, G, Mani, LY, Liabeuf, S

المصدر: Clinical kidney journal. 16(12):2378-2392

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:153925798Test

المؤلفون: Pepin, M, Klimkowicz-Mrowiec, A, Godefroy, O, Delgado, P, Carriazo, S, Ferreira, AC, Golenia, A, Malyszko, J, Grodzicki, T, Giannakou, K, Paolisso, G, Barbieri, M, Garneata, L, Mocanu, CA, Liabeuf, S, Spasovski, G, Zoccali, C, Bruchfeld, A, Farinha, A, Arici, M, Capasso, G, Wiecek, A, Massy, ZA

المصدر: European journal of neurology. 30(9):2899-2911

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:153299935Test

المؤلفون: Viggiano, D, Bruchfeld, A, Carriazo, S, de Donato, A, Endlich, N, Ferreira, AC, Figurek, A, Fouque, D, Franssen, CFM, Giannakou, K, Goumenos, D, Hoorn, EJ, Nitsch, D, Ortiz, A, Pesic, V, Rastenyte, D, Soler, MJ, Rroji, M, Trepiccione, F, Unwin, RJ, Wagner, CA, Wiecek, A, Zacchia, M, Zoccali, C, Capasso, G

المصدر: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 37(Suppl 2):45-54

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:148538302Test

المؤلفون: Bakris, GL, Agarwal, R, Anker, SD, Pitt, B, Ruilope, LM, Nowack, C, Kolkhof, P, Ferreira, AC, Schloemer, P, Filippatos, G

المصدر: American journal of nephrology. 50(5):333-344

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:142370620Test

المؤلفون: Mota, PC, Soares, ML, Ferreira, AC, Santos, RF, Cavaleiro Rufo, J, Vasconcelos, D, Carvalho, A, Guimarães, S, Vasques-Nóvoa, F, Cardoso, C, Melo, N, Alexandre, AT, Coelho, D, Novais-Bastos, H, Morais, A

المساهمون: Instituto de Saúde Pública

الوصف: Introduction and Objectives: Hypersensitivity pneumonitis (HP) is an interstitial lung disease with diverse clinical features that can present a fibrotic phenotype similar to idiopathic pulmonary fibrosis (IPF) in genetically predisposed individuals. While several single nucleotide polymorphisms (SNPs) have been associated with IPF, the genetic factors contributing to fibrotic HP (fHP) remain poorly understood. This study investigated the association of MUC5B and TOLLIP variants with susceptibility, clinical presentation and survival in Portuguese patients with fHP. Material and Methods: A case-control study was undertaken with 97 fHP patients and 112 controls. Six SNPs residing in the MUC5B and TOLLIP genes and their haplotypes were analyzed. Associations with risk, survival, and clinical, radiographic, and pathological features of fHP were probed through comparisons among patients and controls. Results: MUC5B rs35705950 and three neighboring TOLLIP variants (rs3750920, rs111521887, and rs5743894) were associated with increased susceptibility to fHP. Minor allele frequencies were greater among fHP patients than in controls (40.7% vs 12.1%, P<0.0001; 52.6% vs 40.2%, P = 0.011; 22.7% vs 13.4%, P = 0.013; and 23.2% vs 12.9%, P = 0.006, respectively). Haplotypes formed by these variants were also linked to fHP susceptibility. Moreover, carriers of a specific haplotype (G-T-G-C) had a significant decrease in survival (adjusted hazard ratio 6.92, 95% CI 1.73–27.64, P = 0.006). Additional associations were found between TOLLIP rs111521887 and rs5743894 variants and decreased lung function at baseline, and the MUC5B SNP and radiographic features, further highlighting the influence of genetic factors in fHP. Conclusion: These findings suggest that TOLLIP and MUC5B variants and haplotypes may serve as valuable tools for risk assessment and prognosis in fibrotic hypersensitivity pneumonitis, potentially contributing to its patient stratification, and offer insights into the genetic factors influencing the clinical ...

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/FCT/CEEC IND 3ed/2020.01350.CEECIND/CP1623/CT0001/PT; info:eu-repo/grantAgreement/FCT/Concurso para Financiamento de Projetos de Investigação Científica e Desenvolvimento Tecnológico em Todos os Domínios Científicos - 2020/PTDC/MEC-RES/0158/2020/PT; Pulmonology. 2024 Feb 2:S2531-0437(24)00007-2. doi:10.1016/j.pulmoe.2024.01.002. Online ahead of print.; https://www.sciencedirect.com/science/article/pii/S2531043724000072?via%3DihubTest; https://hdl.handle.net/10216/157583Test

الإتاحة: https://doi.org/10.1016/j.pulmoe.2024.01.002Test
https://hdl.handle.net/10216/157583Test

المؤلفون: Jorgensen, HS, Ferreira, AC, D'Haese, P, Haarhaus, M, Vervloet, M, Lafage-Proust, MH, Ferreira, A, Evenepoel, P

المصدر: Kidney international. 102(2):431-434

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:150389615Test

المؤلفون: Covas, R, Lardy, S, Silva, LR, Rey, B, Ferreira, AC, Theron, F, Tognetti, A, Faivre, B, Doutrelant, C

المصدر: BEHAVIORAL ECOLOGY. 33(3):504-517

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:148829337Test

المؤلفون: Luengo-Pérez, LM, Fernández-Bueso, M, Ambrojo, A, Guijarro, M, Ferreira, AC, Pereira-da-Silva, L, Moreira-Rosário, A, Faria, A, Calhau, C, Daly, A, MacDonald, A, Rocha, JC

مصطلحات موضوعية: Anthropometry, Biomarkers, Body Composition, Body Mass Index, Cardiovascular Diseases* / etiology, Humans, Phenylketonurias* / complications, HDE MTB

الوصف: Cardiovascular diseases are the main cause of mortality worldwide. Patients with phenylketonuria (PKU) may be at increased cardiovascular risk. This review provides an overview of clinical and metabolic cardiovascular risk factors, explores the connections between body composition (including fat mass and ectopic fat) and cardiovascular risk, and examines various methods for evaluating body composition. It particularly focuses on nutritional ultrasound, given its emerging availability and practical utility in clinical settings. Possible causes of increased cardiometabolic risk in PKU are also explored, including an increased intake of carbohydrates, chronic exposure to amino acids, and characteristics of microbiota. It is important to evaluate cardiovascular risk factors and body composition in patients with PKU. We suggest systematic monitoring of body composition to develop nutritional management and hydration strategies to optimize performance within the limits of nutritional therapy. ; info:eu-repo/semantics/publishedVersion

العلاقة: Nutrients . 2023 Dec 18;15(24):5133; http://hdl.handle.net/10400.17/4791Test

الإتاحة: https://doi.org/10.3390/nu15245133Test
http://hdl.handle.net/10400.17/4791Test

المؤلفون: De Menezes, MT, Moreira, FRR, Whittaker, C, Santos, FM, Queiroz, DC, Geddes, V, Fonseca, PLC, De Jesus, JG, Mendes-Oliveira, F, Reis-Souza, V, Santos, B, Zauli, DAG, De Lima, AB, De Brito Mendonça, C, Alvim, LB, Do Prado Silva, J, Malta, FSV, De Souza Ferreira, AC, Faria, NR, Sabino, EC, Aguiar, RS

المصدر: 13 ; 1

جغرافية الموضوع: Switzerland

الوصف: Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.

العلاقة: Viruses; http://hdl.handle.net/10044/1/103288Test

الإتاحة: https://doi.org/10.3390/v15020585Test
http://hdl.handle.net/10044/1/103288Test

المؤلفون: Matias, P, Ávila, G, Ferreira, AC, Laranjinha, I, Ferreira, A

مصطلحات موضوعية: Magnesium, Mortality, Hyperparathyroidism, Secondary, Vascular Calcification, Vitamin D, HCC NEF

الوصف: Magnesium and vitamin D play important roles in most cells of the body. These nutrients act in a coordinated fashion to maintain physiologic functions of various organs, and their abnormal balance could adversely affect these functions. Therefore, deficient states of both nutrients may lead to several chronic medical conditions and increased cardiovascular and all-cause mortality. Chronic kidney disease (CKD) patients have altered metabolism of both magnesium and vitamin D. Some studies indicate that magnesium could have a role in the synthesis and metabolism of vitamin D, and that magnesium supplementation substantially reversed the resistance to vitamin D treatment in some clinical situations. Recent observational studies also found that magnesium intake significantly interacted with vitamin D status and, particularly with the risk of cardiovascular mortality. It is therefore essential to ensure adequate levels of magnesium to obtain the optimal benefits of vitamin D supplementation in CKD patients. In this review, we discuss magnesium physiology, magnesium and vitamin D metabolism in CKD, potential metabolic interactions between magnesium and vitamin D and its clinical relevance, as well as the possible role of magnesium supplementation to assure adequate vitamin D levels. ; info:eu-repo/semantics/publishedVersion

العلاقة: Clin Kidney J . 2023 Jun 1;16(11):1776-1785; http://hdl.handle.net/10400.17/4849Test

الإتاحة: https://doi.org/10.1093/ckj/sfad123Test
http://hdl.handle.net/10400.17/4849Test