المؤلفون: Albalawi, Mohammed, Alwasaidi, Turki, Almohammadi, Mohammed, Alzarief, Ashraf Ahmad, Elyamany, Ghaleb

المصدر: Clinical Case Reports ; volume 11, issue 10 ; ISSN 2050-0904 2050-0904

الوصف: COVID 19 is a serious infection that originated in Wuhan, China and has resulted in worldwide morbidity and mortality. It continues to be a major health concern in 2022, being associated with multiorgan failure. Although the pathophysiology of the disease and its complications are not well understood, it is believed that a cytokine storm, triggered by complement activation may be responsible for the severity and complications of the disease. As of now, there is no definitive treatment available. Hematological changes associated with COVID‐19 include lymphopenia, anemia, thrombocytopenia, disseminated intravascular coagulopathy, and thrombosis. Paroxysmal nocturnal hemoglobinuria (PNH), on the other hand, is an acquired clonal hematopoietic stem cell disorder that occurs due to an acquired PIG‐A mutation affecting the hematopoietic stem cells. Interestingly, PNH exhibits some clinical and laboratory manifestations like those seen in COVID‐19. In this report, we present a rare case of PNH that developed following a COVID‐19 infection.

الإتاحة: https://doi.org/10.1002/ccr3.8011Test

المؤلفون: Chentoufi, Aziz Alami, Uyar, F. Aytul, Chentouf, Hiba A., Alzahrani, Khalid, Paz, Maria, Bahnassy, Ahmed, Elyamany, Ghaleb, Elghazaly, Assem

مصطلحات موضوعية: Genetic diversity, Allele frequency, Allele and haplotype homozygosity, Human leukocyte antigens (HLA), Transfusion-associated-graft versus host disease (TA-GVHD)

الوصف: Human leukocyte antigens (HLA) diversity has a tremendous impact on shaping the transplantation practices, transfusion-associated graft versus host disease prevention strategies, and host–pathogen interactions. Here, we conducted a retrospective study of HLA class I and class II homozygosity at allelic and haplotype levels in unrelated individuals genotyped from 2012 to 2016 in a tertiary hospital in the capital of Saudi Arabia. Among 5,000 individuals, 2,773 individuals meet inclusion criteria and were retrospectively analyzed for HLA-A, -B, -C–DRB1, and -DQB1 homozygosity at allelic and haplotype levels. HLA molecular typing was performed using a commercial reverse sequencespecific oligonucleotide (rSSO) kit. We were able to identify 15 HLA-A, 20 HLA-B, 11 HLA-C, 13 HLA-DRB1, and five HLA-DQB1 homozygous alleles demonstrating a very low genetic diversity in the Saudi population. The highest homozygosity in HLA class I was found in locus C followed by A and B (20.3% > 16.1% > 15.5%; p < 0.001) where the most homozygote alleles were A*02 (9.2%), B*51 and B*50 (5.7% and 3.7%), and C*07, C*06, and C*15 (7.2%, 5.48%, and 3.3%) and in HLA class II, the highest homozygosity was found in locus DQB1 compared to DRB1 (31.71% > 19.2%; p < 0.001), with the most common homozygote alleles being DRB1*07 and DRB1*04 (5.33% and 4.2%) and DQB1*02, DQB1*06, and DQB1*03 (13.55%, 7.92%, and 7.64%). The frequency of finding an individual with one homozygote allele was (24.6%), two homozygote alleles (13.5%), three homozygote alleles (4.7%), four homozygote alleles (3.4%), and five alleles were (4.8%). The most frequent homozygote haplotypes are A*23~C*06~B*50~DRB1*07~DQB1*02 and A*02~C*06~B*50~DRB1*07~DQB1*02. This study shows low diversity of both class I and II alleles and haplotypes in the Saudi population, which would have a significant impact on shaping the transplantation practices, transfusion-associated graft versus host disease prevention strategies, and host–pathogen interactions. ; KFMC ...

وصف الملف: application/pdf; application/vnd.openxmlformats-officedocument.wordprocessingml.document

العلاقة: 1664-8021 (online); https://repository.up.ac.za/handle/2263/88056Test

الإتاحة: https://doi.org/10.3389/fgene.2022.898235Test
https://repository.up.ac.za/handle/2263/88056Test

المؤلفون: Elyamany, Ghaleb

المصدر: Electronic Physician; Vol. 8 No. 8 (2016): August 2016; 2747-2751 ; 2008-5842

مصطلحات موضوعية: Transfusion-transmissible infection, Blood Donor, Stem cell donor, Saudi Arabia, Syphilis

الوصف: Introduction:Syphilis is one of the known transfusion-transmissible infections and causes 100,000 deaths yearly, with around 90% of these deaths occurring in the developing world. Little data is available regarding the prevalence of syphilis among Saudi blood and stem cell donors. We conducted a survey on the incidence of syphilis among all blood and stem cell donors. Methods:This study was conducted at the Prince Sultan Military Medical City in Riyadh, Saudi Arabia in the 10 years period data during 2006-2015. Data were analyzed about full history, physical examination, age, sex, weight, profession, marital status, number of the donations, data of last donation, having a relation who received blood transfusion, as well as the screening test results of the donated blood. We determined the seroprevalence of infection and compared by sex and other variable through frequency analysis, Chi square, Fisher, and prevalence ratios. Results:Approximately 240,000 blood donors were screened and studied in the period of study. Most of the blood donors were male (98.3%) and 89% of them were citizens of Saudi Arabia. According to our findings, we estimated that, in the last 10 years, approximately 0.044% of all the blood donors were syphilis positive cases. No cases were detected as positive for syphilis among stem cell donors. Only 60 blood donors tested positive for syphilis. In addition, we studied 202 stem cell transplant donors during the same period, of which 59% were male and none texted positive for syphilis. Conclusions:A concerted effort between the government, health care providers, regulatory bodies and accreditation agencies have all contributed in eliminating the risk of spreading syphilis among blood donors.

العلاقة: https://medtech.ichsmt.org/index.php/EPJ/article/view/1776/3019Test; https://medtech.ichsmt.org/index.php/EPJ/article/view/1776/3020Test; https://medtech.ichsmt.org/index.php/EPJ/article/view/1776/3021Test; https://medtech.ichsmt.org/index.php/EPJ/article/view/1776Test

الإتاحة: https://medtech.ichsmt.org/index.php/EPJ/article/view/1776Test

المؤلفون: ELYAMANY, GHALEB, ALKHAYAT, Nawaf, SHARIF, Omar AL, ELBORAI, Yasser, SHAHRANI, Mohammad AL, ALSUHAIBANI, Omar

المصدر: Hematology, Transfusion and Cell Therapy ; volume 44, page S15-S16 ; ISSN 2531-1379

مصطلحات موضوعية: Hematology, Immunology and Allergy

الإتاحة: https://doi.org/10.1016/j.htct.2022.09.1212Test
https://api.elsevier.com/content/article/PII:S2531137922013360?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2531137922013360?httpAccept=text/plainTest

المؤلفون: Alkhayat, Nawaf, Alshahrani, Mohammad, Elyamany, Ghaleb, Sedick, Qanita, Ibrahim, Walid, Hamzi, Hasna, Binhassan, Amal, Othman, Mohamed, Alshieban, Saeed, Aljabry, Mansour S., Asiri, Shuaa, Alzouman, Muneerah, Alsuhaibani, Omar, Alabbas, Fahad, Alsharif, Omar, Elborai, Yasser

المساهمون: SANAD Children’s Cancer Support Association and SANAD Research Grants Program

المصدر: Journal of the Egyptian National Cancer Institute ; volume 33, issue 1 ; ISSN 2589-0409

مصطلحات موضوعية: Cancer Research, Oncology

الوصف: Background Hodgkin lymphoma (HL) is lymphoid neoplasm usually affecting lymphatic system; it accounts 3.6% of cancers in Saudi Arabia. Modern treatment protocols had shown particular success rates in overall-survival (OS) and event-free-survival (EFS). In our study, we reviewed the medical records of 80 pediatric and young adolescent patients diagnosed HL from January 2006 to July 2020, treated at tertiary care hospital in Riyadh, Saudi Arabia. Demographic, clinical, and pathological data were explored. First line therapy was ABVD, COG, COPP, R-CHOP, or radiotherapy alone in 53/80 (66.4%), 24/80 (30%), 1/80 (1.2%), 1/80 (1.2%), or 1/80 (1.2%) patients; respectively. Response assessment was done by CT + / − PET scan after first 2 cycles then every 2 cycle and end of therapy. Another assessment was done if any clinical suspicion of recurrence. Results Median age 11 (range 3–16) years. Males to females 1.3:1. Seventy-two out of eighty (90%) patients showed first complete remission (CR1) and maintained remission for median 40 (range 7–136) months. Eight out of eighty (10%) patients showed refractory disease. Nineteen patients received salvage therapy (ICE or ESHAP/brentuximab vedotin or gemcitabine/brentuximab vedotin), 14/19 (73.7%) had 2nd complete remission (CR2) for median time 24 (ranged 9–78) months, while 5/19 (26.3%) did not show any response. Five-year OS and EFS were 95% and 75%. Two patients had 2ry malignant neoplasms, one had AML and died, the other had malignant fibrous histocytoma and still alive. None of our patients had fertility problem. Also, they did not experience chronic pulmonary or cardiotoxicity. Classic Hodgkin’s lymphoma: nodular sclerosis subtype was more prominent (55%) than mixed cellularity subtype (22.5%), which is similar to several European and US studies, lymphocyte rich (11.25%) and lymphocyte depleted (0%), while nodular lymphocyte predominant Hodgkin’s lymphoma (11.25%). Conclusions Our study provided unique descriptive study of childhood HL, in Saudi Arabia, with ...

الإتاحة: https://doi.org/10.1186/s43046-021-00078-0Test

المؤلفون: Alabbas, Fahad, Elyamany, Ghaleb, Alanzi, Talal, Ali, Tahani Bin, Albatniji, Fatma, Alfaraidi, Huda

المساهمون: SOBI

المصدر: BMC Pediatrics ; volume 21, issue 1 ; ISSN 1471-2431

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الوصف: Background Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal syndrome that is characterized by strong activation of the immune system from hyperinflammatory cytokines. Symptoms of HLH patients include fever, hepatosplenomegaly, cytopenia, and hyperferritinemia. Inherited HLH is classified as primary, whereas secondary HLH (sHLH) occurs when acquired from non-inherited reasons that include severe infection, immune deficiency syndrome, autoimmune disorder, neoplasm, and metabolic disorder. Wolman’s disease (WD) is a rare and fatal infantile metabolic disorder caused by lysosomal acid lipase deficiency, that exhibits similar clinical signs and symptoms as HLH. This paper reports the case of an infant diagnosed with WD and who presented with sHLH. Case presentation A 4-month-old infant presenting with hepatosplenomegaly, failure to thrive, and other abnormalities. WD diagnosis was confirmed by the presence of the LIPA gene homozygous deletion c.(428 + 1_967-1)_(*1_?)del. The infant also met the HLH-2004 diagnostic criteria. Conclusions Metabolic disorder such as WD should be investigated in infants fulfilling the HLH criteria to diagnose the underlying condition. More studies are needed to understand the link between WD and sHLH and to identify appropriate therapies.

الإتاحة: https://doi.org/10.1186/s12887-021-02541-2Test

المؤلفون: Alabbas, Fahad, Elyamany, Ghaleb, Alkhayat, Nawaf, AlShahrani, Mohammad, Ibrahim, Walid, Elborai, Yasser, Binhassan, Amal, Hamzi, Hasna, Al Thibani, Nour, Alakel, Sami, Alsharif, Faisal, Alsuhaibani, Omar, Alsharif, Omar

المصدر: Health Services Insights ; volume 14, page 117863292110293 ; ISSN 1178-6329 1178-6329

مصطلحات موضوعية: Public Health, Environmental and Occupational Health, Health Policy

الوصف: Advances in pediatric cancer treatment and dramatic improvement in long-term survival have made health-related quality of life (HRQOL) a priority. This study describes the HRQOL of Saudi children on cancer treatment, given the paucity of data on the subject. Parents of children undergoing cancer treatment between the ages of 2 and 12 years enrolled to answer the Arabic version of the parent proxy report PedsQL™ 3.0 cancer module. The module items were reverse-scored to a linear scale from 0 to 100, in which higher scores indicated a better HRQOL. Of the 95 study participants, 61 (64.2%) were hematological malignancies and 34 (35.8%) solid malignancies. The mean score of our sample’s total HRQOL was 72.3, which is in line with the results of similar studies worldwide. The lowest scores were observed for procedural anxiety (60.14), perceived physical appearance (67.37), and treatment anxiety (67.58), while the highest were for communication (80.21), nausea (78.32), and cognitive problems (78.32). Significant associations were reported between the patients aged younger than 5 years and procedural anxiety, those aged 5 years or older and perceived physical appearance, and frequent hospital visits and worry. Healthcare professionals should consider the poor HRQOL sub-scales and their associated risks to improve treatment outcomes.

الإتاحة: https://doi.org/10.1177/11786329211029351Test

المؤلفون: Elborai, Yasser, Alkhayat, Nawaf, Elyamany, Ghaleb, Alshahrani, Mohammad, Ibrahim, Walid, Othman, Mohamed, Hamzi, Hasna, Binhassan, Amal, Aljabry, Mansour S, Alqawahmed, Raniah, alrusayni, Yasir, Abdulhaleem, Khadijah, Alsuhaibani, Omar, Alsharif, Omar

المساهمون: SANAD Children’s Cancer Support Association

المصدر: Rare Tumors ; volume 13, page 203636132199733 ; ISSN 2036-3613 2036-3613

مصطلحات موضوعية: Oncology, Histology

الوصف: Rare pediatric tumors are heterogeneous group containing a variety of histopathological diseases, they represent approximately 10% of all childhood cancers. These rare tumors had a diversity of histology and clinical behaviors that pose different challenges to the investigators. Exploring different pediatric rare tumors. The data were reviewed, retrospectively, through the medical records of seven rare pediatric diseases between 2012 and 2019. Giant cell fibroblastoma (GCF) presented as painless swelling in the trunk, positive for CD34 with PTEN gene mutation. Neuroglial heterotopic tissue presented in 7 days old girl with facial asymmetry and bulging in the oral cavity, maximal de-bulking was done, histopathology was positive for GFAP and S100p. Left side neck mass, surgically excised revealed non-metastatic salivary grand mucoepidermoid carcinoma. Follow up without any chemotherapy or radiotherapy for 5 years with complete remission. Mesenchymal chondrosarcoma (MCS) presented in maxillofacial bones by persistent nasal bleeding, HEY1-NCOA2 fusion gene confirmed the diagnosis. Extra-osseous Ewing sarcoma (EES) presented as rubbery painless swelling in the scalp with fusion transcript involving EWSR1-FL11. Juvenile xanthogranuloma (JXG) presented by butter fly like skin patch in the face with foamy histiocytes in upper dermis with few Touton giant cells, extensive systemic involvement of lung and bone marrow. Metastatic ovarian choriocarcinoma with choriocarcinoma syndrome received induction two different lines of chemotherapy and consolidated with autologous stem cell transplant. Seven pediatric rare tumors, with different aspects of challenges in diagnosis and management, despite the absence of formal protocols and rarity of other center experiences.

الإتاحة: https://doi.org/10.1177/2036361321997331Test

المؤلفون: Elyamany, Ghaleb, Fouly, Ahmed, Alqahtani, Abdulmalik, Alrumeh, Assem, Asiri, Shuaa, Faifi, Salman Ali, Alshieban, Saeed

المصدر: Case Reports in Oncology ; volume 14, issue 1, page 244-248 ; ISSN 1662-6575

مصطلحات موضوعية: Oncology

الوصف: Plasmablastic lymphoma (PBL) is a rare subtype of non-Hodgkin’s lymphoma that is associated with acquired immunodeficiency syndrome (AIDS), characterized by its association with Epstein-Barr virus (EBV), aggressive nature, and plasmacytic/plasmablastic differentiation. PBL remains a therapeutic and diagnostic challenge. Diagnosis of PBL by fine-needle aspiration cytology (FNAC) is reported infrequently. We herein describe the cytodiagnosis of a rare case of HIV-negative PBL in a 58-year-old man without EBV infection presented by parotid swelling. The current case study highlights the cytomorphologic features that may help to distinguish PBL from other mimics. However, although the cytomorphologic features may suggest PBL, a definitive diagnosis requires additional studies including tissue biopsy and immunohistochemistry, in addition to biochemical investigations and radiological workup to establish the diagnosis and exclude similar conditions. In conclusion, FNAC is a very useful, simple, rapid and reliable procedure for diagnosis of the lymphoma. FNAC provided the earliest clue to diagnosis of PBL, which was later confirmed by tissue biopsy.

الإتاحة: https://doi.org/10.1159/000509746Test
https://www.karger.com/Article/Pdf/509746Test

المؤلفون: Owaidah, Tarek, Alabbas, Fahad, Alhazmi, Iman, Al Saeed, Hussain, Balelah, Saud, ElYamany, Ghaleb, Kashari, Ohoud, Qari, Mohamad, Saleh, Mahasen, Roushdy, Sherif, ElBagoury, Marwan

المصدر: Journal of Applied Hematology ; volume 12, issue 3, page 123 ; ISSN 1658-5127

مصطلحات موضوعية: Hematology

الإتاحة: https://doi.org/10.4103/joah.joah_79_21Test