Cardiovascular complications - 3

التفاصيل البيبلوغرافية
العنوان:	Cardiovascular complications - 3
المؤلفون:	Becker, Luis E., Melk, Anette, Kloske, Kim M., Böckler, Dittmar, Hakimi, Maani, Koleganova, Nadezda, Ziebart, Heike, Zeier, Martin, Gross, Marie Luise, Jefferies, Helen, Virk, Bhupinder, Doss, Sheila, Sun, Sumi, Moran, John, Schiller, Brigitte, McIntyre, Christopher, Sevinc, Ebru, Kircelli, Fatih, Ozen, Pinar, Bozkurt, Devrim, Toz, Huseyin, Cirit, Mustafa, Ok, Ercan, Steppan, Sonja, Passlick-Deetjen, Jutta, Asci, Gulay, Harvey, Philip, Holt, Ashley, Nicholas, Johann, Nair, Hari, Dasgupta, Indranil, Vlahakos, Demetrios, Kalogeropoulou, Sofia, Leftheriotis, Dionyssios, Flevari, Panagyota, Panou, Fotis, Katsoudas, Spiros, Bacharaki, Demetra, Kremastinos, Dimitrios, Wang, Angela Y.M., Lam, Christopher W.K., Wang, Mei, Chan, Iris H.S., Lui, Siu-Fai, Zhang, Yan, Sanderson, John E., Valcheva, Petya, Panizo, Sara, Parisi, Eva, Bozic, Milica, Navarro, Juan F., Coll, Blai, Fernandez, Elvira, Valdivielso, Jose M., Burton, James, Selby, Nicholas, Lee, Eveline, Tan, Kay B., John, Biju, Wenzelburger, Frauke, Tan, Yu Ting, Heatlie, Grant, Davies, Simon J., Pan, Qiangwen, Ruan, Xiong, Wheeler, David, Norman, Jill, Varghese, Zac, Moorhead, John, Unwin, Robert, Varela, Alexandre, Tanigushi, Elise, Faria-Neto, Jose R., Pecoits-Filho, Roberto, Abedi Azar, Sima, Nakhjavani, Mohammadreza J., Tarzamni, Mohammad Kazem, Calviño, Jesus, Cillero, Sonia, Villaverde, Pedro, Rodriguez, Isabel, Valdes, Francisco, Almirall, Jaume, Lopez, Thais, Martinez, Joan-Carles, Gallardo, Xavier, Castañer, Eva, Valls, Rafel, Valenzuela, M.-Pau, Martin, Nadia, Betancourt, Lorelei, Garcia, Manuel, Garzotto, Francesco, Cruz, Dinna, Lentini, Paolo, de Cal, Massimo, Basso, Flavio, Zanella, Monica, Nalesso, Federico, Brendolan, Alessandra, Thomaseth, Karl, Ronco, Claudio, Cases, Aleix, Palomo, Marta, Molina, Patricia, Navalon, Fulgencio, Vera, Manel, Escolar, Gines, Diaz-Ricart, Maribel, Higa, Elisa Mieko Suemitsu, Gloria, Maria Aparecida, Carvalho, Aluísio Barbosa, Lee, YoungSook, Lee, Kyung Jin, Lee, Sahng, Bang, KiTae, Kim, Seong Suk, Thang, Hue Danh, Grooteman, Muriel, Serné, Erik, Smulders, Yvo, Ter Wee, Piet, Tangelder, Geert Jan, Nubé, Menso, Patel, Rajan, Powell, Joanna, Mark, Patrick, McQuarrie, Emily, McNaught, Gillian, Steedman, Tracey, Dargie, Henry, Jardine, Alan G., Chen, Limeng, Fan, Xiaohong, Zeng, Yong, Ge, Guangli, Guo, Zhenni, Tao, Jianling, Xu, Hong, Sun, Yang, Li, Xuemei, Li, Xuewang, Ahmed, Muhammad Shahed, Salim, A., McCoy, C., Vithlani, K., Wong, C.F., Demirturk, Mustafa, Caliskan, Yasar, Ozkok, Abdullah, Sakaci, Tamer, Oflaz, Huseyin, Unsal, Abdulkadir, Yildiz, Alaattin, Konca, Ceyla, Derici, lver, Mutluay, Rüya, Agirgün, agri, Gönen, Sevim, Ayerden Ebinç, Fatma, Altiok Reis, Kadriye, Erten, Yasemin, Bali, Musa, Arinsoy, Turgay, Sindel, Sükrü, Jardine, Alan, Turkmen, Kultigin, Gorgulu, Numan, Uysal, Mukremin, John, Stephen, Sigrist, Mhairi, Bode-Boeger, Stefanie, Kielstein, Jan, Rafalia, K., Pai, P., del Rosso, Goffredo, del Vecchio, Lucia, Lusenti, Tiziano, degli Esposti, Ezio, Sturani, Alessandra, Timio, Mario, Losito, Attilio, Hypertension Working Group Italian Society of Nephrology, Ferrario, M., Signorini, M.G., Raimann, J., Kruse, A., Thijssen, S., Kotanko, P., Levin, N.W., Cerutti, S., Saygi, Serkan, Dheir, Hamad, Duman, Soner, Kayikcioglu, Meral, Yilmaz, Mumtaz, Ozkahya, Mehmet, Snaedal, Sunna, Qureshi, Abdul Rashid, Axelsson, Jonas, Heimburger, Olof, Carrero, Juan Jesus, Lindholm, Bengt, Stenvinkel, Peter, Barany, Peter, Covic, Adrian, Stancu, Simona, Voroneanu, Luminita, Mircescu, Gabriel, Champagne, Kateri, Barre, Paul, Tangri, Navdeep, Iqbal, Sameena, Kimoff, R. John, Chan, Cian, Lam, Christina, McIntyre, Christopher W., Bucharles, Sergio G., Barberato, Silvio H., Stinghen, Andrea E., Branco, Fabio, Gruber, Betina, Piekala, Luciana, Dambiski, Ana, Cardoso, Maria C., Cassi, Helio V., Rostoker, Guy, Griuncelli, Mireille, Loridon, Christelle, Benmaadi, Abbes, Illouz, Eric, Gonzalez, Fernando, Lorca, Eduardo, Zavala, Carlos, Espinoza, Mauricio, Yakupoglu, Ulkem, Cigerli, Ozlem, Ozdemir, Nurhan, Haberal, Mehmet, van Eps, Carolyn, Jeffries, Leanne, Haluska, Brian, Hawley, Carmel, Jeffries, Janine, Johnson, David, Campbell, Scott, Isbel, Nicole, Mudge, David, Marwick, Thomas, Caldararu, Carmen, Gliga, Mirela, Barb, Ilie T., Roman, Violeta, Dogaru, Grigore, Christopher, Kenneth, Aker, Sendogan, Bantis, Christos, Reis, Philip, Heering, Peter, Kuhr, Nicola, Schwandt, Christina, Rump, Lars-Christian, Ivens, Katrin, Mou, Shan, Ni, Zhaohui, Wang, Qin, Cao, Liou, Qian, Jiaqi, Rusu, Crina, Moldovan, Diana, Ghigolea, Bogdan, Orasan, Remus, Patiu, Ioan Mihai, Gherman, Mirela, Fang, Te-Chao, Wang, Chih-Hsien, Shen, Tsu-Wang, Lai, Yu-Hsien, Hsu, Bang-Gee
بيانات النشر:	Oxford University Press
سنة النشر:	2010
المجموعة:	HighWire Press (Stanford University)
مصطلحات موضوعية:	Monday
الوصف:	INTRODUCTION AND AIMS: It has been argued that an accelerated cellular aging process in chronic kidney disease (CKD) and diabetes (DM) functions as a permissive factor for the rapid development of atherosclerosis. We compared the presence of the cell cycle inhibitors p16INK4a, p21 and p53, which are associated to telomere dependent cellular senescence, in autopsy subjects with CKD and DM. METHODS: Aorta and coronary artery samples from autopsy subjects (n = 51) were divided in three groups according to autopsy reports: controls (n=19), subjects without CKD and DM; CKD (n=24) CKD stadium 4 or 5 without DM; DM (n=8) insulin-dependent DM without CKD. Immunohistochemistry was performed in paraffin sections with antibodies against p16INK4a, p21 and p53. Analysis was performed in separate on three different vessel locations: intima, media and plaque bearing areas. Results were given as positive cells/high power field, statistical analysis was performed using ANOVA. RESULTS: Age and gender distributions were similar between groups. P16INK4a was equally detected in both coronary and aortic vessels from controls. In coronary, p16INK4a expression in all examined areas was significantly higher in CKD and DM when compared to controls, p=0.003 (figure 1). In the aorta, these significances were observed within the media layer, p=0.006. In the intima and plaque bearing areas of the aorta, p16INK4aexpression was significanlty higher in CKD compared to controls, p=0.006 (figure 1). CKD was the only group where a p21 media expression was observed. There a significantly higher p21 expression in the intima of coronary and aorta in CKD and DM compared to contols, p=0.03. P53 was only found in media from CKD or DM patients, not in controls. Aortic p53 expression in media was significantly higher in DM group when compared to controls, p=0.04. Figure 1 . p16INK4a expression. * p<0.05 vs. control, ** p<0.01 vs control. CONCLUSIONS: In our observation, the strongest association detected was between ...
نوع الوثيقة:	text
وصف الملف:	text/html
اللغة:	English
العلاقة:	http://ckj.oxfordjournals.org/cgi/content/short/2/suppl_2/ii510Test; http://dx.doi.org/10.1093/ndtplus/2.s2.50Test
DOI:	10.1093/ndtplus/2.s2.50
الإتاحة:	https://doi.org/10.1093/ndtplus/2.s2.50Test http://ckj.oxfordjournals.org/cgi/content/short/2/suppl_2/ii510Test
حقوق:	Copyright (C) 2010, European Renal Association - European Dialysis and Transplant Assoc
رقم الانضمام:	edsbas.7A9D2DBF
قاعدة البيانات:	BASE

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الوصف
DOI:	10.1093/ndtplus/2.s2.50