المؤلفون: Malekpour, Shirin, Allen, Cameron, Sagar, Ambuj, Scholz, Imme, Persson, Åsa, Miranda, J. Jaime, Bennich, Therese, Dube, Opha Pauline, Kanie, Norichika, Madise, Nyovani, Shackell, Nancy, Montoya, Jaime C., Pan, Jiahua, Hathie, Ibrahima, Bobylev, Sergey N., Agard, John, Al-Ghanim, Kaltham

المصدر: Nature. 621(7978):250-254

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-198421Test
https://doi.org/10.1038/d41586-023-02808-xTest

المؤلفون: Broadbent, Gail Helen, Metternicht, Graciela, Wiedmann, Thomas, Allen, Cameron

المصدر: Broadbent , G H , Metternicht , G , Wiedmann , T & Allen , C 2024 , ' Transforming Australia's road fleet with electric vehicles : strategies and impediments affecting net-zero emissions targets for 2050 ' , Case Studies on Transport Policy , vol. 16 , 101191 . https://doi.org/10.1016/j.cstp.2024.101191Test

مصطلحات موضوعية: Electric vehicles, Government policy, Sustainability

الوصف: A complete and rapid transition to electromobility can minimise road fleet emissions. Electric vehicles (EV) will be essential for decarbonising road transport, which in 2022 generated 19% of Australia's total emissions. Unlike New Zealand, which implemented multiple policies since 2016, limited policy support in Australia for EVs means uptake lags. Creating opportunities for decarbonising road transport and the electricity supply could accelerate the clean energy transition and reduce fossil-fuel dependence. This paper's primary purpose is to suggest policy mechanisms to expedite Australia's road fleet electrification by 2050. Results show that implementation of evidence-based policies, and ensuring their ongoing functionality, will be necessary to achieve the goal. We provide recommendations for the future direction of Australia's federal government policy to enhance a rapid transition to EVs. Its role is critical in supporting the transformation by adopting appropriate targets and policies to encourage EV uptake, transitioning electricity completely to renewable sources, deploying adequate charging infrastructure and maintaining it and the forced-phase out of residual fossil-fuelled cars. A faster transition means fewer emissions and less likelihood of exceeding the emissions budget.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.cstp.2024.101191Test
https://research.monash.edu/en/publications/58b92028-014f-46a9-9108-16a3beb73ae6Test
https://researchmgt.monash.edu/ws/files/594789188/587247494_oa.pdfTest
http://www.scopus.com/inward/record.url?scp=85189870765&partnerID=8YFLogxKTest

المؤلفون: Allen, Cameron, Biddulph, Annabel, Wiedmann, Thomas, Pedercini, Matteo, Malekpour, Shirin

المصدر: Allen , C , Biddulph , A , Wiedmann , T , Pedercini , M & Malekpour , S 2024 , ' Modelling six sustainable development transformations in Australia and their accelerators, impediments, enablers, and interlinkages ' , Nature Communications , vol. 15 , no. 1 , 594 . https://doi.org/10.1038/s41467-023-44655-4Test

الوصف: There is an urgent need to accelerate progress on the Sustainable Development Goals (SDGs) and recent research has identified six critical transformations. It is important to demonstrate how these transformations could be practically accelerated in a national context and what their combined effects would be. Here we bridge national systems modelling with transformation storylines to provide an analysis of a Six Transformations Pathway for Australia. We explore important policies to accelerate progress, synergies and trade-offs, and conditions that determine policy success. We find that implementing policy packages to accelerate each transformation would boost performance on the SDGs by 2030 (+23% above the baseline). Policymakers can maximize transformation synergies through investments in energy decarbonization, resilience, social protection, and sustainable food systems, while managing trade-offs for income and employment. To overcome resistance to transformations, ambitious policy action will need to be underpinned by technological, social, and political enabling conditions.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1038/s41467-023-44655-4Test
https://research.monash.edu/en/publications/db30b0d4-8c6e-4191-b048-c812365a9866Test
https://researchmgt.monash.edu/ws/files/585313042/569633801_oa.pdfTest
http://www.scopus.com/inward/record.url?scp=85182644459&partnerID=8YFLogxKTest

المؤلفون: Pathipati, Mythili P., Scott, Luisa L., Griser, Allen Cameron, Staller, Kyle

المصدر: Neurogastroenterology & Motility ; ISSN 1350-1925 1365-2982

الوصف: Background Mahana™ IBS is a Food and Drug Administration‐cleared prescription mobile application designed to deliver 3 months of gut‐directed cognitive behavioral therapy (CBT) to adults ≥22 years old with irritable bowel syndrome (IBS). We assessed whether gut‐directed CBT delivered digitally improved outcomes in IBS management. Methods We studied users who had a dispensed physician prescription for Mahana™ IBS between August 2021 and August 2023. The primary outcome was change in IBS symptom severity (IBS‐SSS) score. Key Results For the 843 patients, 324 (38%) completed half of the program up to session 5, and 162 (19%) of participants completed the full program up to session 10. Median age was 41 years, median IBS‐SSS was 270 (moderate severity), IBS‐mixed subtype was most common (23%) followed by IBS‐C (20%) and IBS‐D (19%). The change in IBS‐SSS was −81.0 ( p = < 0.001) after session 5 and − 104.4 ( p = < 0.001) after session 10. In multivariate analyses, a higher baseline IBS‐SSS (OR 1.59; 95% CI 1.26–2.01) and high baseline Perceived Stress Scale (PSS) score predicted non‐response (OR 0.95; 95% CI 0.91–0.98) while older age (OR 1.10 per decade; 95% CI 1.01–1.20), prescription source from a healthcare provider (as opposed to third party telehealth encounter, OR 1.48; 95% CI 1.07–2.05), and payment for the app (OR 1.93; 95% CI 1.41–2.63) predicted adherence. Conclusions & Inferences Use of a digital mobile application for gut‐directed CBT improved symptoms of IBS. Digital health applications have the potential to democratize CBT and allow integrated care to scale for patients with IBS.

الإتاحة: https://doi.org/10.1111/nmo.14811Test

المؤلفون: Allen, Cameron, Malekpour, Shirin

المصدر: Sustainability Science ; ISSN 1862-4065 1862-4057

مصطلحات موضوعية: Management, Monitoring, Policy and Law, Nature and Landscape Conservation, Sociology and Political Science, Ecology, Geography, Planning and Development, Health (social science), Global and Planetary Change

الإتاحة: https://doi.org/10.1007/s11625-024-01473-xTest

المؤلفون: White, Thomas G., Poole, Hannah, McBride, Emma E., Oliver, Matthew, Descamps, Adrien, Fletcher, Luke B., Angermeier, W. Alex, Allen, Cameron H., Appel, Karen, Condamine, Florian P., Curry, Chandra B., Dallari, Francesco, Funk, Stefan, Galtier, Eric, Gamboa, Eliseo J., Gauthier, Maxence, Graham, Peter, Goede, Sebastian, Haden, Daniel, Kim, Jongjin B., Lee, Hae Ja, Ofori-Okai, Benjamin K., Richardson, Scott, Rigby, Alex, Schoenwaelder, Christopher, Sun, Peihao, Witte, Bastian L., Tschentscher, Thomas, Zastrau, Ulf, Nagler, Bob, Hastings, J. B., Monaco, Giulio, Gericke, Dirk O., Glenzer, Siegfried H., Gregori, Gianluca

المساهمون: U.S. Department of Energy, Office of Science, Fusion Energy Sciences, National Nuclear Security Administration, Deutsche Forschungsgemeinschaft, Natural Sciences and Engineering Research Council of Canada, Basic Energy Sciences, Science and Technologies Facilities Council, U.K. Research & Innovation Future Leaders Fellowship

المصدر: Physical Review Research ; volume 6, issue 2 ; ISSN 2643-1564

الإتاحة: https://doi.org/10.1103/physrevresearch.6.l022029Test

المؤلفون: Allen, Cameron, Malekpour, Shirin, Mintrom, Michael

المصدر: Allen , C , Malekpour , S & Mintrom , M 2023 , ' Cross-scale, cross-level and multi-actor governance of transformations toward the Sustainable Development Goals : a review of common challenges and solutions ' , Sustainable Development , vol. 31 , no. 3 , pp. 1250-1267 . https://doi.org/10.1002/sd.2495Test

مصطلحات موضوعية: governance, integration, reform, scales, sustainable development goals, transformations

الوصف: The importance of governance for achieving the Sustainable Development Goals (SDGs) is uncontested. However, the design of effective governance arrangements to initiate and deliver the necessary transformations is complex, multi-scale, and multi-actor and many knowledge gaps remain. For would-be reformers, a fundamental challenge arises because all transformative efforts must proceed, at least initially, within existing governance arrangements which can be highly resistant to change. While there is a rich literature on governance of transformations, knowledge remains fragmented. In this paper, we first review this literature and highlight important governance scales as spatial, jurisdictional, sectoral and temporal. We highlight common governance challenges that may arise from tensions within and between these scales, and how governance framings and design choices of actors may accentuate or ameliorate these challenges. To further illustrate, we review a selection of recent case studies on transformations to the SDGs and highlight common governance challenges and solutions. We conclude by suggesting five concrete steps that would-be reformers could usefully take to increase the likelihood that their transformation efforts will meet with success.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/sd.2495Test
https://research.monash.edu/en/publications/0e7e0772-2767-4ff7-923b-2314c9792592Test
https://researchmgt.monash.edu/ws/files/502528667/432422555_oa.pdfTest
http://www.scopus.com/inward/record.url?scp=85146156699&partnerID=8YFLogxKTest

المؤلفون: Allen, Cameron, Malekpour, Shirin

المصدر: Allen , C & Malekpour , S 2023 , ' Unlocking and accelerating transformations to the SDGs : a review of existing knowledge ' , Sustainability Science , vol. 18 , pp. 1939-1960 . https://doi.org/10.1007/s11625-023-01342-zTest

مصطلحات موضوعية: Acceleration, Leverage points, Sustainable Development Goals (SDGs), Tipping points, Transformations, Transitions

الوصف: As we approach the 2030 deadline to achieve the Sustainable Development Goals (SDGs), there is a growing sense of urgency around the need to accelerate the necessary transformations. These encompass a broad range of systems and require fundamental changes in system goals and design. In this paper, we undertake a narrative review of the literature relating to the acceleration of transformations and offer a framework for unlocking and accelerating transformations to the SDGs. While there is no blueprint for acceleration, there is an expanding knowledge base on important dynamics, impediments and enabling conditions across diverse literatures which can help to inform strategic interventions by actors. The emerging literature on positive tipping points and deep leverage points identifies opportunities to rewire systems design so that important system feedbacks create the conditions for acceleration. Transformation takes time and actors will need to build momentum to reorient systems around new goals, informed by knowledge of common policy, technology and behavioural feedbacks that govern system dynamics. Where resistance is strong, actors can seek to augment system design in ways that weaken balancing feedbacks that stabilise existing system configurations and strengthen reinforcing feedbacks that promote emerging system configurations oriented towards the SDGs. Well-designed and sequenced interventions can promote innovation and behaviour change and build and maintain political support. This can build critical enabling conditions and push systems towards large-scale tipping points, paving the way for decisive policy action that is crucial for triggering acceleration. We conclude by highlighting gaps and priorities for further research.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1007/s11625-023-01342-zTest
https://research.monash.edu/en/publications/83a77f85-1c1b-49b9-8270-050c756fd904Test
https://researchmgt.monash.edu/ws/files/503910725/471576731_oa.pdfTest
http://www.scopus.com/inward/record.url?scp=85160848375&partnerID=8YFLogxKTest

المؤلفون: Erickson, Rachel, Huang, Chang, Allen, Cameron, Ireland, Joanna, Roth, Gwynne, Zou, Zhongcheng, Lu, Jinghua, Lafont, Bernard A. P., Garza, Nicole L., Brumbaugh, Beniah, Zhao, Ming, Suzuki, Motoshi, Olano, Lisa, Brzostowski, Joseph, Fischer, Elizabeth R., Twigg, Homer L., III, Johnson, Reed F., Sun, Peter D.

المساهمون: Medicine, School of Medicine

المصدر: PMC

مصطلحات موضوعية: Infection, SARS-CoV-2, Viral infection

الوصف: Severe COVID-associated lung injury is a major confounding factor of hospitalizations and death with no effective treatments. Here, we describe a non-classical fibrin clotting mechanism mediated by SARS-CoV-2 infected primary lung but not other susceptible epithelial cells. This infection-induced fibrin formation is observed in all variants of SARS-CoV-2 infections, and requires thrombin but is independent of tissue factor and other classical plasma coagulation factors. While prothrombin and fibrinogen levels are elevated in acute COVID BALF samples, fibrin clotting occurs only with the presence of viral infected but not uninfected lung epithelial cells. We suggest a viral-induced coagulation mechanism, in which prothrombin is activated by infection-induced transmembrane serine proteases, such as ST14 and TMPRSS11D, on NHBE cells. Our finding reveals the inefficiency of current plasma targeted anticoagulation therapy and suggests the need to develop a viral-induced ARDS animal model for treating respiratory airways with thrombin inhibitors.

وصف الملف: application/pdf

العلاقة: Nature Communications; Erickson R, Huang C, Allen C, et al. SARS-CoV-2 infection of human lung epithelial cells induces TMPRSS-mediated acute fibrin deposition. Nat Commun. 2023;14(1):6380. Published 2023 Oct 11. doi:10.1038/s41467-023-42140-6; https://hdl.handle.net/1805/39481Test

الإتاحة: https://doi.org/10.1038/s41467-023-42140-6Test
https://hdl.handle.net/1805/39481Test

المؤلفون: Bennich, Therese, Persson, Åsa, Beaussart, Raphaëlle, Allen, Cameron, Malekpour, Shirin

المصدر: One Earth ; volume 6, issue 11, page 1465-1476 ; ISSN 2590-3322

مصطلحات موضوعية: Earth and Planetary Sciences (miscellaneous), General Environmental Science

الإتاحة: https://doi.org/10.1016/j.oneear.2023.10.008Test
https://api.elsevier.com/content/article/PII:S259033222300458X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S259033222300458X?httpAccept=text/plainTest