دورية أكاديمية
The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview
| العنوان: | The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview |
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| المؤلفون: | Baccarani M, Castagnetti F, Gugliotta G, Rosti G, Soverini S, Albeer A, Pfirrmann M, Bekadja MA, Entasoltan B, Nachi M, Elghandour A, El Sorady M, Abdelfattah R, El Nahass Y, Samra M, Azzazi M, Elsobki E, Moussa M, Fahmy O, Mattar M, Shehata SE, Azmy E, Bolarinwa RA, Eid S, Khelif A, Hached F, Menif S, Rahman H, Huang XJ, Jiang Q, Ye YX, Zhu HL, Chen SN, Varma N, Ganesan P, Gundeti S, Malhotra H, Radhakrishnan VS, Kumar L, Sharawat SK, Seth T, Ausekar BV, Balasubramanian P, Poopak B, Inokuchi K, Kim DW, Al Kindi S, Mirasol A, Qari M, Goh YT, Shih LY, Branford S, Lion T, Valent P, Burgstaller S, Thaler J, Labar B, Zadro R, Mayer J, Zackova D, Faber E, Pallisgaard N, Xavier-Mahon F, Lippert E, Cayuela JM, Rea D, Millot F, Suttorp M, Hochhaus A, Niederwieser D, Saussele S, Haferlach T, Jeromine S, Panayiotidis P, Conneally E, Langabeer S, Nagler A, Rupoli S, Santoro N, Albano F, Ottaviani E, Rambaldi A, Stagno F, Molica S, Biagiotti C, Scappini B, Lemoli R, Iurlo A, Pungolino E, Menna G, Pane F, Gottardi E, Rege-Cambrin G, Binotto G, Putti MC, Falzetti F, Visani G, Galimberti S, Musto P, Abruzzese E, Breccia M, Giona F, Chiusolo P, Sica S, Fava C, Ferrero D, Tiribelli M, Bonifacio M, Griskevicius L, Musteata V, Janssen J, Prejzner W, Sacha T, Waclaw J, Almeida AM, Kulikov S, Turkina A, Bogdanovic A, Zupan I, Marce S, Cervantes F, Steegmann JL, Kotlyarchuk K, Milner BJ, Rose S, Clench T, Waits P, Austin S, Wickham C, Clark R, Apperley J, Claudiani S, Foroni L, Szydlo R, Burt E, Bescoby R, Cork L, O'Brien S, Green B, Hawtree S, Watson M, Bengio RM, Larripa I, Pavlovsky C, Moiraghi B, de Pinna CAR, Magalhaes GHR, Pagnano K, Funke V, Tavares RS, Prado A, Azevedo AA, Fogliatto L, Bonecker S, Centrone R, Moellman A, Conchon M, Centurion ME, Prado AI, Lopez JL, Petruzziello F, Bendit I. |
| المساهمون: | Baccarani, M, Castagnetti, F, Gugliotta, G, Rosti, G, Soverini, S, Albeer, A, Pfirrmann, M, Bekadja, Ma, Entasoltan, B, Nachi, M, Elghandour, A, El Sorady, M, Abdelfattah, R, El Nahass, Y, Samra, M, Azzazi, M, Elsobki, E, Moussa, M, Fahmy, O, Mattar, M, Shehata, Se, Azmy, E, Bolarinwa, Ra, Eid, S, Khelif, A, Hached, F, Menif, S, Rahman, H, Huang, Xj, Jiang, Q, Ye, Yx, Zhu, Hl, Chen, Sn, Varma, N, Ganesan, P, Gundeti, S, Malhotra, H, Radhakrishnan, V, Kumar, L, Sharawat, Sk, Seth, T, Ausekar, Bv, Balasubramanian, P, Poopak, B, Inokuchi, K, Kim, Dw, Al Kindi, S, Mirasol, A, Qari, M, Goh, Yt, Shih, Ly, Branford, S, Lion, T, Valent, P, Burgstaller, S, Thaler, J, Labar, B, Zadro, R, Mayer, J, Zackova, D, Faber, E, Pallisgaard, N, Xavier-Mahon, F, Lippert, E, Cayuela, Jm, Rea, D, Millot, F, Suttorp, M, Hochhaus, A, Niederwieser, D, Saussele, S, Haferlach, T, Jeromine, S, Panayiotidis, P, Conneally, E, Langabeer, S, Nagler, A, Rupoli, S, Santoro, N, Albano, F, Ottaviani, E, Rambaldi, A, Stagno, F, Molica, S, Biagiotti, C, Scappini, B, Lemoli, R, Iurlo, A, Pungolino, E, Menna, G, Pane, F, Gottardi, E, Rege-Cambrin, G, Binotto, G, Putti, Mc, Falzetti, F, Visani, G, Galimberti, S, Musto, P |
| سنة النشر: | 2019 |
| المجموعة: | Università degli Studi di Bari Aldo Moro: CINECA IRIS |
| مصطلحات موضوعية: | Adolescent, Adult, Age Factor, Aged, 80 and over, Child, Preschool, Female, Fusion Proteins, bcr-abl, Global Health, Human, Infant, Newborn, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, Male, Middle Aged, Odds Ratio, Prevalence, Transcriptional Activation, Young Adult, Gene Expression Regulation, Leukemic |
| الوصف: | There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia. Their frequency has never been systematically investigated. In a series of 45503 newly diagnosed CML patients reported from 45 countries, it was found that the proportion of e13a2 (also known as b2a2) and of e14a2 (also known as b3a2), including the cases co-expressing e14a2 and e13a2, was 37.9% and 62.1%, respectively. The proportion of these two transcripts was correlated with gender, e13a2 being more frequent in males (39.2%) than in females (36.2%), was correlated with age, decreasing from 39.6% in children and adolescents down to 31.6% in patients ≥ 80 years old, and was not constant worldwide. Other, rare transcripts were reported in 666/34561 patients (1.93%). The proportion of rare transcripts was associatedwith gender (2.27% in females and 1.69% in males) and with age (from 1.79% in children and adolescents up to 3.84% in patients ≥ 80 years old). These data show that the differences in proportion are not by chance. This is important, as the transcript type is a variable that is suspected to be of prognostic importance for response to treatment, outcome of treatment, and rate of treatment-free remission. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/30675008; info:eu-repo/semantics/altIdentifier/wos/WOS:000466360100010; volume:33; issue:5; firstpage:1173; lastpage:1183; numberofpages:11; journal:LEUKEMIA; http://hdl.handle.net/11586/273088Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85060651613 |
| DOI: | 10.1038/s41375-018-0341-4 |
| الإتاحة: | https://doi.org/10.1038/s41375-018-0341-4Test http://hdl.handle.net/11586/273088Test |
| رقم الانضمام: | edsbas.A57D458D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41375-018-0341-4 |
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