Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either gram negative or gram positive bacteria
| العنوان: | Serum procalcitonin elevation in critically ill patients at the onset of bacteremia caused by either gram negative or gram positive bacteria |
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| المؤلفون: | Jean-Pierre Quenot, Serge Aho, Sylvain Ladoire, Pierre Emmanuel Charles, Niels-Olivier Olsson, Jean-Marc Doise, Sébastien Prin, Bernard Blettery |
| المصدر: | BMC Infectious Diseases, Vol 8, Iss 1, p 38 (2008) BMC Infectious Diseases |
| بيانات النشر: | BMC, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Calcitonin, Male, medicine.medical_specialty, Gram-negative bacteria, medicine.drug_class, Calcitonin Gene-Related Peptide, Gram-positive bacteria, Antibiotics, Bacteremia, Gram-Positive Bacteria, Gastroenterology, Medical Records, Procalcitonin, law.invention, lcsh:Infectious and parasitic diseases, Cohort Studies, Sepsis, law, Internal medicine, Gram-Negative Bacteria, medicine, Humans, lcsh:RC109-216, Protein Precursors, Gram-Positive Bacterial Infections, Aged, biology, business.industry, Middle Aged, biology.organism_classification, medicine.disease, bacterial infections and mycoses, Intensive Care Units, Logistic Models, Treatment Outcome, Infectious Diseases, Gram staining, ROC Curve, Immunology, Female, SOFA score, France, Gram-Negative Bacterial Infections, business, Research Article |
| الوصف: | Background In the ICU, bacteremia is a life-threatening infection whose prognosis is highly dependent on early recognition and treatment with appropriate antibiotics. Procalcitonin levels have been shown to distinguish between bacteremia and noninfectious inflammatory states accurately and quickly in critically ill patients. However, we still do not know to what extent the magnitude of PCT elevation at the onset of bacteremia varies according to the Gram stain result. Methods Review of the medical records of every patient treated between May, 2004 and December, 2006 who had bacteremia caused by either Gram positive (GP) or Gram negative (GN) bacteria, and whose PCT dosage at the onset of infection was available. Results 97 episodes of either GN bacteremia (n = 52) or GP bacteremia (n = 45) were included. Procalcitonin levels were found to be markedly higher in patients with GN bacteremia than in those with GP bacteremia, whereas the SOFA score value in the two groups was similar. Moreover, in the study population, a high PCT value was found to be independently associated with GN bacteremia. A PCT level of 16.0 ng/mL yielded an 83.0% positive predictive value and a 74.0% negative predictive value for GN-related bacteremia in the study cohort (AUROCC = 0.79; 95% CI, 0.71–0.88). Conclusion In a critically ill patient with clinical sepsis, GN bacteremia could be associated with higher PCT values than those found in GP bacteremia, regardless of the severity of the disease. |
| اللغة: | English |
| تدمد: | 1471-2334 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3c14bc16b449601644df70dbcfad696Test http://www.biomedcentral.com/1471-2334/8/38Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c3c14bc16b449601644df70dbcfad696 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712334 |
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