دورية أكاديمية
Sirtuin 1 and endothelial glycocalyx
| العنوان: | Sirtuin 1 and endothelial glycocalyx |
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| المؤلفون: | Lipphardt, Mark, Song, Jong Wook, Goligorsky, Michael S |
| المصدر: | http://lobid.org/resources/99370672927306441Test#!, 472(8):991-1002. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Endothelial Cells/metabolism [MeSH], Invited Review, Humans [MeSH], Endothelium/metabolism [MeSH], Nitric Oxide/metabolism [MeSH], Sheddases, Animals [MeSH], NF-kB, Glycocalyx, Syndecan-4, Oxidative stress, Sirtuin 1/metabolism [MeSH], Glycocalyx/metabolism [MeSH], Sirtuin 1 |
| الوصف: | Sirtuin1 deficiency or reduced activity comprises one of the hallmarks of diseases as diverse as chronic cardiovascular, renal, and metabolic, some malignancies, and infections, as well as aging-associated diseases. In a mouse model of endothelium-limited defect in sirtuin 1 deacetylase activity, we found a dramatic reduction in the volume of endothelial glycocalyx. This was associated with the surge in the levels of one of key scaffolding heparan sulfate proteoglycans of endothelial glycocalyx, syndecan-4, and specifically, its extracellular domain (ectodomain). We found that the defect in endothelial sirtuin 1 deacetylase activity is associated with (a) elevated basal and stimulated levels of superoxide generation (via the FoxO1 over-acetylation mechanism) and (b) increased nuclear translocation of NF-kB (via p65 over-acetylation mechanism). These findings laid the foundation for the proposed novel function of sirtuin 1, namely, the maintenance of endothelial glycocalyx, particularly manifest in conditions associated with sirtuin 1 depletion. In the forthcoming review, we summarize the emerging conceptual framework of the enhanced glycocalyx degradation in the states of defective endothelial sirtuin 1 function, thus explaining a broad footprint of the syndrome of endothelial dysfunction, from impaired flow-induced nitric oxide production, deterrent leukocytes infiltration, increased endothelial permeability, coagulation, and pro-inflammatory changes to development of microvascular rarefaction and progression of an underlying disease. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6467270Test; https://doi.org/10.1007/s00424-020-02407-zTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376508Test/ |
| DOI: | 10.1007/s00424-020-02407-z |
| الإتاحة: | https://doi.org/10.1007/s00424-020-02407-zTest https://repository.publisso.de/resource/frl:6467270Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376508Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.E5936A51 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00424-020-02407-z |
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