التفاصيل البيبلوغرافية
| العنوان: |
The activation of β-catenin by Gαs contributes to the etiology of phenotypes seen in Fibrous dysplasia and McCune-Albright syndrome. |
| المؤلفون: |
Zhong, Zhendong, Williams, Bart O, Steensma, Matthew R |
| المصدر: |
IBMS BoneKEy; Jun2012, Vol. 9 Issue 6, p113, 1p |
| مصطلحات موضوعية: |
FIBROUS dysplasia of bone, CELL transformation, CELLULAR pathology, ETIOLOGY of diseases, ABNORMALITIES in the anatomical extremities, THERAPEUTICS |
| مستخلص: |
The authors discuss aspects of the contribution of β-catenin activation by Gαs to the etiology of phenotypes in McCune-Albright syndrome and fibrous dysplasia (FD). They are critical on the condition of FD to the enhanced proliferation of osteoblast precursors with terminal differentiation failure. Also investigated is the significant morbidity effect on the structural alterations in FD including limb-length discrepancies, angular deformity and fracture. |
| قاعدة البيانات: |
Complementary Index |
