Estimating GFR by Serum Creatinine, Cystatin C, and β2-Microglobulin in Older Adults: Results From the Canadian Study of Longevity in Type 1 Diabetes
| العنوان: | Estimating GFR by Serum Creatinine, Cystatin C, and β2-Microglobulin in Older Adults: Results From the Canadian Study of Longevity in Type 1 Diabetes |
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| المؤلفون: | Yuliya Lytvyn, Vera Bril, Hillary A. Keenan, Julie A. Lovshin, Genevieve Boulet, Mohammed A. Farooqi, Leif E. Lovblom, Andrej Orszag, Bruce A. Perkins, Alanna Weisman, Vesta Lai, Narinder Paul, Michael H. Brent, David Z.I. Cherney, Daniel Scarr, Petter Bjornstad |
| المصدر: | Kidney International Reports, Vol 4, Iss 6, Pp 786-796 (2019) Kidney International Reports |
| بيانات النشر: | Elsevier, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | medicine.medical_specialty, type 1 diabetes, Population, 030232 urology & nephrology, Urology, Renal function, 030204 cardiovascular system & hematology, urologic and male genital diseases, lcsh:RC870-923, inulin clearance, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Clinical Research, cystatin C, Medicine, education, older adults, β2-microglobulin, glomerular filtration rate, Type 1 diabetes, Inulin Clearance, Creatinine, education.field_of_study, biology, business.industry, Beta-2 microglobulin, creatinine, medicine.disease, lcsh:Diseases of the genitourinary system. Urology, female genital diseases and pregnancy complications, Cystatin C, chemistry, Nephrology, estimating equations, biology.protein, business, Kidney disease |
| الوصف: | Introduction: Glomerular filtration rate (GFR) is routinely used for clinical assessment of kidney function. However, the accuracy of estimating equations in older adults is uncertain. Methods: In 66 adults with ≥50 years type 1 diabetes (T1D) duration and 73 nondiabetic controls from age/sex-matched subgroups (65 ± 8 years old and 77[55%] were women) we evaluated the performance of estimated GFR (eGFR) by creatinine (Modification of Diet and Renal Disease [MDRD], Chronic Kidney Disease–Epidemiology [CKD-EPI]cr), cystatin C (CKD-EPIcys, CKD-EPIcr-cys), and β2-microglobulin (β2M) compared with measured GFR by inulin clearance (mGFR). Performance was evaluated using metrics of bias (mean difference), precision (SD), and accuracy (proportion of eGFR that differed by >20% of mGFR). Results: Mean mGFR was 104 ± 18 ml/min per 1.73 m2 (range: 70–154 ml/min per 1.73 m2) and was not different between T1D and controls (103 ± 17 vs. 105 ± 19 ml/min per 1.73 m2, P = 0.39). All equations significantly underestimated mGFR (bias: −15 to −30 ml/min per 1.73 m2, P < 0.001 for all comparisons) except for β2M, which had bias of 1.9 ml/min per 1.73 m2 (P = 0.61). Bias was greatest in cystatin C–based equations. Precision was lowest for β2M (SD: 43.5 ml/min per 1.73 m2, P < 0.001 for each comparison). Accuracy was lowest for CKD-EPIcysC (69.1%, P < 0.001 for each comparison). Cystatin C–based equations demonstrated greater bias and lower accuracy in older age subgroups ( |
| اللغة: | English |
| تدمد: | 2468-0249 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42b020c2fe0a943693d9d4799229ff6fTest http://www.sciencedirect.com/science/article/pii/S2468024919300713Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....42b020c2fe0a943693d9d4799229ff6f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24680249 |
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