G9a Is SETting the Stage for Colorectal Oncogenesis
| العنوان: | G9a Is SETting the Stage for Colorectal Oncogenesis |
|---|---|
| المؤلفون: | Christopher J. Bergin, Yannick D. Benoit |
| المصدر: | Genes, Vol 11, Iss 616, p 616 (2020) Genes |
| بيانات النشر: | MDPI AG, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, cancer stem cells, G9a, lcsh:QH426-470, Colorectal cancer, Carcinogenesis, colorectal cancer, Biology, medicine.disease_cause, 03 medical and health sciences, Genetic Heterogeneity, 0302 clinical medicine, Cancer stem cell, Histocompatibility Antigens, Genetics, medicine, Humans, Epigenetics, Stage (cooking), Genetics (clinical), driving mutations, epigenetics, Melanoma, Wnt signaling pathway, Histone-Lysine N-Methyltransferase, medicine.disease, Gene Expression Regulation, Neoplastic, Wnt Proteins, PR-SET Domains, lcsh:Genetics, 030104 developmental biology, 030220 oncology & carcinogenesis, Histone methyltransferase, Perspective, Mutation, Cancer research, Neoplastic Stem Cells, Colorectal Neoplasms |
| الوصف: | Recently, Kato et al. reported recurrent activating mutations in the SET domain of histone methyltransferase G9a, driving an oncogenic cascade in melanoma. The authors also reported correlations between G9a expression and the regulation of the canonical WNT pathway. Although we could not observe such mutations in human colorectal adenocarcinoma, newly reported findings are of high relevance to colorectal cancer, as WNT target gene signatures were closely associated with G9a expression. Here, we put into perspective such new results on G9a expression in colorectal cancers and the potential relationship with tumor heterogeneity and acquisition of neoplastic stemness. |
| اللغة: | English |
| تدمد: | 2073-4425 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6fd21e0c34daa76209c3e389df76781Test https://www.mdpi.com/2073-4425/11/6/616Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a6fd21e0c34daa76209c3e389df76781 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20734425 |
|---|