التفاصيل البيبلوغرافية
| العنوان: |
Bufadienolides with cytotoxic activity from the skins of Bufo bufo gargarizans. |
| المؤلفون: |
Li, Bao-Jing1,2, Tian, Hai-Yan2, Zhang, Dong-Mei2, Lei, Yu-He3, Wang, Lei2,3 cpuwanglei@126.com, Jiang, Ren-Wang2 rwjiang2008@126.com, Ye, Wen-Cai1,2,3 chyewc@gmail.com |
| المصدر: |
Fitoterapia. Sep2015, Vol. 105, p7-15. 9p. |
| مصطلحات موضوعية: |
*ALTERNATIVE medicine, *ANTINEOPLASTIC agents, *ANURA, *BIOLOGICAL models, *PHYSICAL & theoretical chemistry, *DOSE-effect relationship in pharmacology, *LIVER tumors, *LUNG tumors, *NUCLEAR magnetic resonance spectroscopy, *SKIN, *STATISTICAL significance, *DESCRIPTIVE statistics, *IN vitro studies, *PHARMACODYNAMICS, CERVIX uteri tumors |
| مستخلص: |
Twelve new bufadienolides ( 1 – 12 ), along with fourteen known analogues ( 13 – 26 ) were isolated from the skins of Bufo bufo gargarizans Cantor. Their chemical structures were elucidated on the basis of NMR, HRESIMS and X-ray diffraction analysis. Compound 1 was an unusual bufadienolide with 3,19-epoxy moiety and A/B trans ring junction. Compounds 2 – 4 were rare bufadienolides possessing 10-H or 10-carboxyl units. All the isolated compounds were tested for their cytotoxic effects on HepG2, A549 and HeLa cells. Six new compounds ( 2 , 3 , 5 , 6 , 10 and 12 ) displayed significant anti-proliferative activities with IC 50 values ranging from 0.049 to 1.856 μM. Arenobufagin ( 24 ) exhibited the most potent cytotoxic activity with IC 50 value 0.011 μM. In addition, the present data provided more insight into the structure–activity relationships of bufadienolides. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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