دورية أكاديمية
C-23 Steroids from the Venom of Bufo bufo gargarizans
| العنوان: | C-23 Steroids from the Venom of Bufo bufo gargarizans |
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| المؤلفون: | Tian, Hai-Yan, Luo, Shi-Lin, Liu, Jun-Shan, Wang, Lei, Wang, Ying, Zhang, Dong-Mei, Zhang, Xiao-Qi, Jiang, Ren-Wang, Ye, Wen-Cai |
| سنة النشر: | 2013 |
| المجموعة: | The Hong Kong University of Science and Technology: HKUST Institutional Repository |
| مصطلحات موضوعية: | CELLS, APOPTOSIS, BUFADIENOLIDES |
| الوصف: | Five new C-23 steroids (1-5) together with five known bufadienolides (6-10) were isolated from the venom of Bufo bufo gargarizans (ChanSu in Chinese). The structures of the new steroids were elucidated by extensive spectroscopic methods in combination with X-ray diffraction analysis. Among these C-23 steroids, only compound 3 showed cytotoxicities against HepG2 and A549 cancer cells, with respective IC50 values of 26.8 +/- 8.3 and 45.6 +/- 2.5 mu M. In contrast, the bufadienolides (7-10) displayed potent inhibitory activities against these cancer cells, with respective IC50 values in the ranges 0.5-5.5 and 0.6-6.5 mu M, but relatively less cytotoxicity on normal mouse spleen cells. In addition, the Na+/K+-ATPase inhibitory activities of 2, 5, and 7 revealed that the lactone moiety of a bufadienolide was important for the inhibitory activity. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 0163-3864 1520-6025 |
| العلاقة: | http://repository.ust.hk/ir/Record/1783.1-62016Test; Journal of natural products, v. 76, (10), October 2013, p. 1842-1847; https://doi.org/10.1021/np400174fTest; http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0163-3864Test; 1520-6025&rft.volume=76&rft.issue=10&rft.date=2013&rft.spage=1842&rft.aulast=Tian&rft.aufirst=Hai-Yan&rft.atitle=C-23%20Steroids%20from%20the%20Venom%20of%20Bufo%20bufo%20gargarizans&rft.title=Journal%20of%20natural%20products; http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000326319700003Test; http://www.scopus.com/record/display.url?eid=2-s2.0-84886828611&origin=inwardTest |
| DOI: | 10.1021/np400174f |
| الإتاحة: | https://doi.org/10.1021/np400174fTest http://repository.ust.hk/ir/Record/1783.1-62016Test http://lbdiscover.ust.hk/uresolver?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rfr_id=info:sid/HKUST:SPI&rft.genre=article&rft.issn=0163-3864Test; 1520-6025&rft.volume=76&rft.issue=10&rft.date=2013&rft.spage=1842&rft.aulast=Tian&rft.aufirst=Hai-Yan&rft.atitle=C-23%20Steroids%20from%20the%20Venom%20of%20Bufo%20bufo%20gargarizans&rft.title=Journal%20of%20natural%20products http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=LinksAMR&SrcApp=PARTNER_APP&DestLinkType=FullRecord&DestApp=WOS&KeyUT=000326319700003Test http://www.scopus.com/record/display.url?eid=2-s2.0-84886828611&origin=inwardTest |
| رقم الانضمام: | edsbas.4DB7A010 |
| قاعدة البيانات: | BASE |
| تدمد: | 01633864 15206025 |
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| DOI: | 10.1021/np400174f |