المؤلفون: Basu, B, Dean, E, Puglisi, M, Greystoke, A, Ong, M, Burke, W, Cavallin, M, Bigley, G, Womack, C, Harrington, EA, Green, S, Oelmann, E, de Bono, JS, Ranson, M, Banerji, U

المساهمون: De Bono, Johann, Banerji, Udai

مصطلحات موضوعية: Humans, Neoplasms, Benzamides, Morpholines, Pyrimidines, Multiprotein Complexes, Administration, Oral, Dose-Response Relationship, Drug, Adult, Aged, Middle Aged, Female, Male, TOR Serine-Threonine Kinases, Drug-Related Side Effects and Adverse Reactions, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2

وصف الملف: Print-Electronic; 3419; application/pdf

العلاقة: Clinical cancer research : an official journal of the American Association for Cancer Research, 2015, 21 (15), pp. 3412 - 3419; https://repository.icr.ac.uk/handle/internal/3867Test

الإتاحة: https://doi.org/10.1158/1078-0432.ccr-14-2422Test
https://repository.icr.ac.uk/handle/internal/3867Test

المؤلفون: Schuliga, Michael, Pechkovsky, Dmitri V, Read, Jane, Waters, David W, Blokland, Kaj E C, Reid, Andrew T, Hogaboam, Cory M, Khalil, Nasreen, Burgess, Janette K, Prêle, Cecilia M, Mutsaers, Steven E, Jaffar, Jade, Westall, Glen, Grainge, Christopher, Knight, Darryl A

المصدر: Schuliga , M , Pechkovsky , D V , Read , J , Waters , D W , Blokland , K E C , Reid , A T , Hogaboam , C M , Khalil , N , Burgess , J K , Prêle , C M , Mutsaers , S E , Jaffar , J , Westall , G , Grainge , C & Knight , D A 2018 , ' Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts ' , Journal of cellular and molecular medicine , vol. 22 , no. 12 , pp. ....

مصطلحات موضوعية: cyclin-dependent kinase inhibitors, fibroblasts, idiopathic pulmonary fibrosis, mechanistic target of rapamycin complex 1, mitochondria, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, rapamycin, reactive oxygen species and mitoTEMPO, adult, article, controlled study, DNA damage response, enzyme activity, fibrosing alveolitis, homeostasis, human, human cell, lung fibroblast, mitochondrion, phenotype, primary culture, senescence, signal transduction, stress, antioxidant, cyclin dependent kinase inhibitor, endogenous compound, etoposide, mammalian target of rapamycin complex 1, peroxisome proliferator activated receptor gamma coactivator 1alpha

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/0a2e6b1f-cbef-442f-b9ce-8a1336f3a848Test

الإتاحة: https://doi.org/10.1111/jcmm.13855Test
https://hdl.handle.net/11370/0a2e6b1f-cbef-442f-b9ce-8a1336f3a848Test
https://research.rug.nl/en/publications/0a2e6b1f-cbef-442f-b9ce-8a1336f3a848Test
https://pure.rug.nl/ws/files/71233489/Schuliga_et_al_2018_Journal_of_Cellular_and_Molecular_Medicine_1_.pdfTest

المؤلفون: Louis-Auguste, J, Besa, E, Zyambo, K, Munkombwe, D, Banda, R, Banda, T, Watson, A, Mayneris-Perxachs, J, Swann, J, Kelly, P

مصطلحات موضوعية: MTOR, Zambia, amino acids, clinical trial, confocal endomicroscopy, environmental enteropathy, metabolomics, micronutrients, morphometry, Adult, Bacterial Translocation, Dietary Supplements, Female, Glutamine, Humans, Intestinal Diseases, Intestinal Mucosa, Intestine, Small, Leucine, Male, Mechanistic Target of Rapamycin Complex 1, Middle Aged, Tryptophan

وصف الملف: 1240 - 1252

العلاقة: Am J Clin Nutr; https://qmro.qmul.ac.uk/xmlui/handle/123456789/61465Test

الإتاحة: https://doi.org/10.1093/ajcn/nqz189Test
https://qmro.qmul.ac.uk/xmlui/handle/123456789/61465Test

المؤلفون: Wolin, Edward, Mita, Alain, Mahipal, Amit, Meyer, Tim, Bendell, Johanna, Nemunaitis, John, Munster, Pam N, Paz Ares, Luis Gonzaga, Filvaroff, Ellen H, Li, Shaoyi, Hege, Kristen, de Haan, Hans, Mita, Monica

مصطلحات موضوعية: Administration, Oral, Adult, Aged, Carcinoid Tumor, Cohort Studies, Female, Gastrointestinal Neoplasms, Humans, Male, Maximum Tolerated Dose, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2, Middle Aged, Neuroendocrine Tumors, Pyrazines

العلاقة: Publisher's version; https://doi.org/10.1371/journal.pone.0221994Test.; PLoS One. 2019 ;14(9):e0221994.; http://hdl.handle.net/20.500.12105/9369Test; PloS one

الإتاحة: https://doi.org/20.500.12105/9369Test
https://doi.org/10.1371/journal.pone.0221994Test
https://hdl.handle.net/20.500.12105/9369Test

المؤلفون: Basu, B, Krebs, MG, Sundar, R, Wilson, RH, Spicer, J, Jones, R, Brada, M, Talbot, DC, Steele, N, Ingles Garces, AH, Brugger, W, Harrington, EA, Evans, J, Hall, E, Tovey, H, de Oliveira, FM, Carreira, S, Swales, K, Ruddle, R, Raynaud, FI, Purchase, B, Dawes, JC, Parmar, M, Turner, AJ, Tunariu, N, Banerjee, S, de Bono, JS, Banerji, U

المساهمون: Hall, Emma, Tovey, Holly, Carreira, Suzanne, Swales, Karen, Ruddle, Ruth, Raynaud, Florence, De Bono, Johann, Banerji, Udai

مصطلحات موضوعية: Humans, Carcinoma, Non-Small-Cell Lung, Ovarian Neoplasms, Lung Neoplasms, Benzamides, Paclitaxel, Morpholines, Pyrimidines, Ribosomal Protein S6 Kinases, Antineoplastic Combined Chemotherapy Protocols, Protein Kinase Inhibitors, Drug Administration Schedule, Maximum Tolerated Dose, Phosphorylation, Adult, Middle Aged, Female, Male, Response Evaluation Criteria in Solid Tumors, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2

وصف الملف: Print; 1925; application/pdf

العلاقة: Annals of oncology : official journal of the European Society for Medical Oncology, 2018, 29 (9), pp. 1918 - 1925; https://repository.icr.ac.uk/handle/internal/2264Test

الإتاحة: https://doi.org/10.1093/annonc/mdy245Test
https://repository.icr.ac.uk/handle/internal/2264Test

المؤلفون: Mateo, J, Olmos, D, Dumez, H, Poondru, S, Samberg, NL, Barr, S, Van Tornout, JM, Jie, F, Sandhu, S, Tan, DS, Moreno, V, LoRusso, PM, Kaye, SB, Schöffski, P

المساهمون: Kaye, Stanley Bernard, Mateo Valderrama, Joaquin

مصطلحات موضوعية: Leukocytes, Mononuclear, Humans, Neoplasms, Imidazoles, Triazines, Multiprotein Complexes, Protein Kinase Inhibitors, Maximum Tolerated Dose, Dose-Response Relationship, Drug, Half-Life, Adult, Aged, Middle Aged, Female, Male, Young Adult, TOR Serine-Threonine Kinases, Mechanistic Target of Rapamycin Complex 1, Mechanistic Target of Rapamycin Complex 2

وصف الملف: Print-Electronic; 896; application/pdf

العلاقة: British journal of cancer, 2016, 114 (8), pp. 889 - 896; https://repository.icr.ac.uk/handle/internal/2960Test

الإتاحة: https://doi.org/10.1038/bjc.2016.59Test
https://repository.icr.ac.uk/handle/internal/2960Test

المؤلفون: Buerger, Claudia, Shirsath, Nitesh, Lang, Victoria, Berard, Alina, Diehl, Sandra, Kaufmann, Roland, Boehncke, Wolf-Henning, Wolf, Peter

المصدر: ISSN: 1932-6203 ; PLOS ONE, vol. 12, no. 7 (2017) e0180853.

مصطلحات موضوعية: info:eu-repo/classification/ddc/616, Adolescent, Adult, Aged, Animals, Cell Differentiation/genetics/physiology, Cell Line, Cell Proliferation/genetics/physiology, Female, Humans, Immunoassay, Immunohistochemistry, Keratinocytes/metabolism/physiology, Male, Mechanistic Target of Rapamycin Complex 1, Mice, Inbred BALB C, Middle Aged, Multiprotein Complexes/genetics/metabolism, RNA, Small Interfering/genetics, Reverse Transcriptase Polymerase Chain Reaction, Signal Transduction/genetics/physiology, TOR Serine-Threonine Kinases/genetics/metabolism, Young Adult

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28700632; https://archive-ouverte.unige.ch/unige:107100Test; unige:107100

الإتاحة: https://doi.org/10.1371/journal.pone.0180853Test
https://archive-ouverte.unige.ch/unige:107100Test

المؤلفون: Glen A. Doherty, Miriam Tosetto, Vanessa Zaiatz Bittencourt, Elizabeth J. Ryan, Fiona Jones

المصدر: Journal of Crohn's & Colitis

مصطلحات موضوعية: Adult, Male, medicine.medical_treatment, Cell, mTORC1, Mechanistic Target of Rapamycin Complex 1, Peripheral blood mononuclear cell, Inflammatory bowel disease, Oxidative Phosphorylation, Intestinal mucosa, medicine, Humans, NK cell, AcademicSubjects/MED00260, Aged, Membrane Potential, Mitochondrial, business.industry, mTORC, Gastroenterology, General Medicine, Original Articles, Middle Aged, medicine.disease, Acquired immune system, Inflammatory Bowel Diseases, Eccojc/1000, mitochondria, immune metabolism, Killer Cells, Natural, medicine.anatomical_structure, Cytokine, Case-Control Studies, Immunology, Leukocytes, Mononuclear, Cytokines, Cytokine secretion, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e6033dd159a82b3d4ac60dd7ec08878Test
http://europepmc.org/articles/PMC8328302Test

المؤلفون: Iacovelli, Stefano, Ricciardi, Maria Rosaria, Allegretti, Matteo, Mirabilii, Simone, Licchetta, Roberto, Bergamo, Paola, Rinaldo, Cinzia, Zeuner, Ann, Foà, Robin, Milella, Michele, McCubrey, James A, Martelli, Alberto M, Tafuri, Agostino

المساهمون: Iacovelli, Stefano, Ricciardi, Maria Rosaria, Allegretti, Matteo, Mirabilii, Simone, Licchetta, Roberto, Bergamo, Paola, Rinaldo, Cinzia, Zeuner, Ann, Foà, Robin, Milella, Michele, Mccubrey, James A, Martelli, Alberto M, Tafuri, Agostino

مصطلحات موضوعية: BH3 mimetic resistance, Mcl-1, acute lymphoblastic leukemia, mTOR inhibition, targeted therapies, Adult, Antineoplastic Agents, Apoptosis, Biomimetics, Biphenyl Compounds, Blotting, Western, Cell Cycle, Cell Proliferation, Child, Drug Resistance, Neoplasm, Female, Humans, Male, Mechanistic Target of Rapamycin Complex 1, Multiprotein Complexes, Myeloid Cell Leukemia Sequence 1 Protein, Nitrophenols, Peptide Fragments, Piperazines, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Proto-Oncogene Proteins, Proto-Oncogene Proteins c-bcl-2, Sirolimus

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/26392332; volume:6; issue:31; firstpage:32089; lastpage:32103; numberofpages:15; journal:ONCOTARGET; http://hdl.handle.net/11562/1066742Test

الإتاحة: https://doi.org/10.18632/oncotarget.5156Test
http://hdl.handle.net/11562/1066742Test

المؤلفون: LLanos, Susana, García-Pedrero, Juana M, Morgado-Palacin, Lucia, Rodrigo, Juan P, Serrano Marugan, Manuel

المساهمون: Unión Europea. Comisión Europea. European Research Council (ERC), Botín Foundation, Fundación Ramón Areces, Fundación AXA, Ministerio de Economía y Competitividad (España)

مصطلحات موضوعية: Adaptor Proteins, Signal Transducing, Adult, Aged, 80 and over, Carcinoma, Squamous Cell, Cell Line, Tumor, Cyclin-Dependent Kinase Inhibitor p21, Female, Gene Expression Regulation, Neoplastic, Genetic Predisposition to Disease, Head and Neck Neoplasms, Humans, Male, Mechanistic Target of Rapamycin Complex 1, Middle Aged, Multiprotein Complexes, Phosphoproteins, TOR Serine-Threonine Kinases

العلاقة: https://doi.org/10.1038/10.1038/ncomms10438Test.; info:eu-repo/grantAgreement/ES/CP13/00013; info:eu-repo/grantAgreement/ES/ PI13/00259; Nat Commun. 2016;7:10438.; http://hdl.handle.net/20.500.12105/7870Test; Nature communications

الإتاحة: https://doi.org/20.500.12105/7870Test
https://doi.org/10.1038/ncomms10438Test
https://doi.org/10.1038/10.1038/ncomms10438Test
https://hdl.handle.net/20.500.12105/7870Test