Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China
| العنوان: | Prevalence and characteristics of mouse mammary tumor virus-like virus associated breast cancer in China |
|---|---|
| المؤلفون: | Jun Lin, Ya-Dan Li, Xiao-Li Zhang, Qiang Shu, Ming Yang, Xian Wang, Faliang Wang, Yongfang Yue, Hongchuan Jin |
| المصدر: | Infectious Agents and Cancer, Vol 16, Iss 1, Pp 1-14 (2021) Infectious Agents and Cancer |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Cancer Research, medicine.medical_specialty, Epidemiology, M.castaneus mouse, viruses, Infectious and parasitic diseases, RC109-216, Virus, law.invention, Mouse mammary tumor virus-like virus (MMTV-LV), 03 medical and health sciences, 0302 clinical medicine, Breast cancer, law, Internal medicine, Breast Fibroadenoma, medicine, skin and connective tissue diseases, Polymerase chain reaction, RC254-282, 030304 developmental biology, 0303 health sciences, Mammary tumor, biology, business.industry, Mouse mammary tumor virus, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, biology.organism_classification, M. domesticus mouse, Infectious Diseases, 030220 oncology & carcinogenesis, House mice, M.musculus mouse, business, Research Article |
| الوصف: | Background Despite extensive molecular epidemiological studies, the prevalence and characteristics of Mouse Mammary Tumor Virus-Like Virus (MMTV-LV) in Chinese women breast cancer are still unclear. Besides, the prevalence of MMTV-LV in women breast cancer tissue varies in different countries and its dependent factors remain inconclusive. Methods In the first part of the study, a case-control study was performed. 119 breast cancer samples (84 from Northern China and 35 from Southern China) and 50 breast fibroadenoma specimens were collected from Chinese women patients. MMTV-like env sequence and the homology to MMTV env gene were analysed by semi-nested polymerase chain reaction (PCR). We also explored the association of MMTV-LV prevalence with sample sources (Southern and Northern China) and patients’ clinicopathological characteristics. To investigate the dependent factors of the prevalence of MMTV-LV in breast cancer worldwide, a meta-analysis was conducted in the second part of the study. Results We found that the prevalence of MMTV-LV was much higher in breast cancer tissues (17.65%) than that in breast fibroadenoma specimens (4.00%) (P P P Conclusion The distribution of house mice may be a crucial environmental factor that explains the geographic differences in human breast cancer incidence. Our findings may provide a potential avenue of prevention, diagnosis and treatment for breast cancer. |
| اللغة: | English |
| تدمد: | 1750-9378 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdc54b8ec67617c3ac417fa44ccffcedTest https://doaj.org/article/2934e3f6ede04b1daee399d9bbae5386Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bdc54b8ec67617c3ac417fa44ccffced |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17509378 |
|---|