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المؤلفون: Ryo Miyamoto, Takashi Kumasaka, Shigeyuki Matsumoto, Tohru Kataoka, Takashi Kawamura, Mitsugu Araki, Fumi Shima, Haruka Taniguchi-Tamura, Chiemi Tsuda, Yasushi Okuno
المصدر: Biochemical and Biophysical Research Communications. 565:85-90
مصطلحات موضوعية: 0301 basic medicine, Mutant, Molecular Conformation, Biophysics, Guanosine, Oncogenic mutant, Crystal structure, Crystallography, X-Ray, medicine.disease_cause, Biochemistry, Proto-Oncogene Proteins p21(ras), 03 medical and health sciences, Molecular dynamics, chemistry.chemical_compound, Residue (chemistry), 0302 clinical medicine, Molecular dynamics simulation, medicine, Humans, Molecular Biology, X-ray crystallography, Mutation, Chemistry, Cell Biology, State transition, 030104 developmental biology, 030220 oncology & carcinogenesis, Intramolecular force, Guanosine Triphosphate, Structural communication, Ras
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ad871a0c14a241079777a22fba1d2f9Test
https://hdl.handle.net/20.500.14094/0100476443Test -
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المؤلفون: Hong Yan, Mengxu Zhu, Debby D. Wang
المصدر: BMC Molecular and Cell Biology, Vol 22, Iss 1, Pp 1-13 (2021)
BMC Molecular and Cell Biologyمصطلحات موضوعية: 0301 basic medicine, Lung Neoplasms, Genotype, Receptor, ErbB-2, Mutant, Geometric properties, Drug resistance, Molecular Dynamics Simulation, Receptor, IGF Type 1, 03 medical and health sciences, 0302 clinical medicine, Molecular dynamics (MD) simulations, medicine, Humans, Epidermal growth factor receptor, Molecular Biology, Protein Kinase Inhibitors, biology, QH573-671, Chemistry, Wild type, Cancer, Cell Biology, Proto-Oncogene Proteins c-met, medicine.disease, Epidermal growth factor receptor (EGFR), ErbB Receptors, Crosstalk (biology), 030104 developmental biology, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, Cancer research, biology.protein, Signaling crosstalk, Mutant Proteins, Signal transduction, Cytology, Tyrosine kinase, EGFR signaling, Signal Transduction, Research Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::200076283f76b06da3ae47d3936f0648Test
https://doaj.org/article/72ff0c4962e545c9be5a7f5d28eacb98Test -
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المؤلفون: Yejia Zhang, Maurizio Pacifici, Gabriella Cs-Szabo, Zuozhen Tian, Ling Qin, Motomi Enomoto-Iwamoto, David Gerard, Frances S. Shofer, Lutian Yao
المصدر: Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reportsمصطلحات موضوعية: 0301 basic medicine, Cell biology, Proteolysis, Science, Mutant, Gene Expression, Diseases, Pathogenesis, Degeneration (medical), Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Antigens, CD, medicine, Animals, Intervertebral Disc, chemistry.chemical_classification, Inflammation, Multidisciplinary, medicine.diagnostic_test, Wild type, Membrane Proteins, Intervertebral disc, Molecular biology, Mice, Mutant Strains, CXCL1, ADAM Proteins, 030104 developmental biology, medicine.anatomical_structure, Enzyme, chemistry, Medicine, ADAM8, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::72c58dbb05da015fe56faa45cf602c63Test
https://doaj.org/article/29482a7dd36f42fc82304c841792897bTest -
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المؤلفون: Jose R. Pinto, Maike Schuldt, Jiayi Pei, Jamie R. Johnston, Michelle Michels, Huan He, Jolanda van der Velden, Corrado Poggesi, Diederik W. D. Kuster, Magdalena Harakalova, Roy Huurman
المساهمون: Physiology, ACS - Heart failure & arrhythmias, Cardiology
المصدر: Journal of Molecular and Cellular Cardiology, 150, 77-90. Academic Press Inc.
Schuldt, M, Johnston, J R, He, H, Huurman, R, Pei, J, Harakalova, M, Poggesi, C, Michels, M, Kuster, D W D, Pinto, J R & van der Velden, J 2021, ' Mutation location of HCM-causing troponin T mutations defines the degree of myofilament dysfunction in human cardiomyocytes ', Journal of Molecular and Cellular Cardiology, vol. 150, pp. 77-90 . https://doi.org/10.1016/j.yjmcc.2020.10.006Test
Journal of Molecular and Cellular Cardiology, 150, 77-90. Academic Pressمصطلحات موضوعية: Adult, Male, 0301 basic medicine, Myofilament, Adolescent, TNNT2, Mutant, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, Myofibrils, Troponin T, Troponin complex, SDG 3 - Good Health and Well-being, Mutant protein, Humans, Myocytes, Cardiac, RNA, Messenger, Molecular Biology, Aged, biology, Chemistry, Cardiomyopathy, Hypertrophic, Middle Aged, Troponin, Molecular biology, 030104 developmental biology, Mutation, Mutation (genetic algorithm), biology.protein, Calcium, Female, Mutant Proteins, Cardiology and Cardiovascular Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4902dc1d40840020e52ff33cf96d21Test
https://doi.org/10.1016/j.yjmcc.2020.10.006Test -
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المؤلفون: Glen R. Monroe, Hannah S. van Meurs, S. T. Paijens, Gijs van Haaften, Edith D.J. Peters, Ferdinando Sereno, Joline F. Roze, Hans W. Nijman, J. W. Groeneweg, Luc R.C.W. van Lonkhuijzen, Anna G.J. Brink, Ronald P. Zweemer, Jurgen M.J. Piek, Christianne A.R. Lok
المساهمون: Obstetrics and Gynaecology, CCA - Imaging and biomarkers, Translational Immunology Groningen (TRIGR), Targeted Gynaecologic Oncology (TARGON)
المصدر: Gynecologic oncology, 162(2), 413-420. Academic Press Inc.
Gynecologic Oncology, 162(2), 413-420. ACADEMIC PRESS INC ELSEVIER SCIENCEمصطلحات موضوعية: Forkhead Box Protein L2, 0301 basic medicine, Mutant, Granulosa cell tumor, medicine.disease_cause, Circulating Tumor DNA, chemistry.chemical_compound, 0302 clinical medicine, Medicine, Digital polymerase chain reaction, Prospective Studies, Promoter Regions, Genetic, Telomerase, Aged, 80 and over, Ovarian Neoplasms, Mutation, ORIGIN, Obstetrics and Gynecology, Middle Aged, Oncology, 030220 oncology & carcinogenesis, Biomarker (medicine), Female, FOXL2, SERUM INHIBIN, TERT, 03 medical and health sciences, HORMONE, AGE, Biomarkers, Tumor, Humans, Tert promoter mutation, TERM-FOLLOW-UP, Aged, business.industry, INHIBIN-B, ctDNA, Biomarker, medicine.disease, Molecular biology, 030104 developmental biology, chemistry, MARKER, OVARY, Neoplasm Recurrence, Local, business, Ovarian cancer, DNA, Hormone
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2b598d94e5a6a244c2f65ae9bd3ca4Test
https://research.rug.nl/en/publications/e55ba04f-bee6-4aa2-b53f-c586e71850f5Test -
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المؤلفون: Xibo Zhang, Wenfeng Wang, Zinian Zhu, Bashan Zhang, Xueming Zhou, Beijing Luo, Rong Li, Aijiao Ding
المصدر: Annals of Human Genetics
مصطلحات موضوعية: animal structures, Mutant, Wnt1 Protein, Biology, medicine.disease_cause, WNT/β‐catenin signaling pathway, 03 medical and health sciences, Osteoclast, Genetics, medicine, Humans, Phosphorylation, Genetics (clinical), Cells, Cultured, beta Catenin, 030304 developmental biology, 0303 health sciences, Mutation, Glycogen Synthase Kinase 3 beta, Osteoblasts, 030305 genetics & heredity, Wnt signaling pathway, Wild type, Osteoblast, Cell Differentiation, Original Articles, Osteogenesis Imperfecta, medicine.disease, Molecular biology, AR‐OI, medicine.anatomical_structure, Phenotype, Gene Expression Regulation, RANKL, Osteogenesis imperfecta, embryonic structures, mutant WNT1, biology.protein, Original Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52114dd46d640c060a9e4e7d66db9d93Test
http://europepmc.org/articles/PMC7590185Test -
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المؤلفون: Anoop Arunagiri, Peter Arvan, Billy Tsai, Michael A. Weiss, Anis Hassan, Leena Haataja, Ming Liu, Balamurugan Dhayalan, Kaitlin Regan
المصدر: Cellular and Molecular Life Sciences
مصطلحات موضوعية: 0301 basic medicine, Protein Folding, Adolescent, Stereochemistry, Mutant, Protein trafficking, Mutation, Missense, 030209 endocrinology & metabolism, Endoplasmic Reticulum, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Insulin-Secreting Cells, Missense mutation, Insulin, Humans, Cysteine, Disulfides, Disulfide bonds, Beta (finance), Molecular Biology, Cells, Cultured, Proinsulin, Pharmacology, chemistry.chemical_classification, Endoplasmic reticulum, Diabetes, ER retention, Cell Biology, Folding (chemistry), 030104 developmental biology, chemistry, Diabetes Mellitus, Type 2, Thiol, Molecular Medicine, Original Article
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48895c1d89b88134df0a713900dad9b1Test
http://europepmc.org/articles/PMC8316239Test -
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المؤلفون: Hong-Wei Wang, Huizhen Zhao, Yuelei Shen, Youchun Wang, Jiajing Wu, Weijin Huang, Jingshu Xie, Jianhui Nie, Lei Chen, Jiawei Yao, Meiyu Wang, Shuo Liu, Yabo Zhang, Jianhui Li, Liu Yacui, Chuan Liu, Yi Yang
المصدر: Cell Discovery, Vol 7, Iss 1, Pp 1-11 (2021)
Cell Discoveryمصطلحات موضوعية: Pattern recognition receptors, 0301 basic medicine, biology, Coronavirus disease 2019 (COVID-19), QH573-671, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Mutant, Rational design, Cell Biology, Biochemistry, Virology, Article, Epitope, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Epitope mapping, Cryoelectron microscopy, Genetics, biology.protein, Antibody, Neutralizing antibody, Cytology, Molecular Biology, 030217 neurology & neurosurgery
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8038c5a791aa55e44adaad718addf35bTest
https://doaj.org/article/f5f86f3f49c4408b9fa670089359cb99Test -
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المؤلفون: Teruhisa Tsuzuki, Kenichi Masumura, Michi Matsumoto, Yasunobu Aoki, Michiyo Matsumoto, Mizuki Ohno, Takehiko Nohmi
المصدر: Genes and Environment, Vol 43, Iss 1, Pp 1-11 (2021)
Genes and Environmentمصطلحات موضوعية: 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, Social Psychology, Mutant, Transgenic rodent assay, Environmental Science (miscellaneous), QH426-470, medicine.disease_cause, Single-base deletion, Mismatch repair, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Adenine nucleotide, medicine, Genetics, QH540-549.5, Mutation, Ecology, Chemistry, Research, Mutagenesis, nutritional and metabolic diseases, Molecular biology, Small intestine, digestive system diseases, 030104 developmental biology, medicine.anatomical_structure, Potassium bromate, MSH2, Oxidative stress, 030220 oncology & carcinogenesis, Tumorigenesis, Carcinogenesis
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d3ed5b6ee94313e6ddb981665f099feTest
https://doaj.org/article/d0f190b721784fe9a066c6b40e96ba1bTest -
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المؤلفون: Weian Zhao, Jie Tian, Qian lu, Bo Pan, Lingjuan Liu, Jing Luo
المصدر: Genes and Diseases, Vol 8, Iss 4, Pp 569-579 (2021)
Genes & Diseasesمصطلحات موضوعية: 0301 basic medicine, Medicine (General), PDE4D reduction, Mutant, macromolecular substances, QH426-470, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, R5-920, Full Length Article, Gene expression, Troponin I, Genetics, Molecular Biology, Genetics (clinical), Actin, cTnIR93H, biology, Chemistry, Histone modifications, Wild type, Phosphodiesterase, Cell Biology, HDAC1, Cell biology, 030104 developmental biology, Histone, 030220 oncology & carcinogenesis, biology.protein, EGCG
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e3e9f0d022307cf0a981880312ee59fTest
http://www.sciencedirect.com/science/article/pii/S235230422030012XTest
