Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats
| العنوان: | Obesity improves myocardial ischaemic tolerance and RISK signalling in insulin-insensitive rats |
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| المؤلفون: | Jason Nigel John Peart, D. Donner, Eugene F. Du Toit, John P. Headrick |
| المصدر: | Disease Models & Mechanisms, Vol 6, Iss 2, Pp 457-466 (2013) Disease Models & Mechanisms |
| بيانات النشر: | The Company of Biologists, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | medicine.medical_specialty, Cardiotonic Agents, Myocardial Infarction, Myocardial Ischemia, Neuroscience (miscellaneous), Medicine (miscellaneous), lcsh:Medicine, Myocardial Reperfusion Injury, Context (language use), In Vitro Techniques, Piperazines, General Biochemistry, Genetics and Molecular Biology, chemistry.chemical_compound, Thinness, Immunology and Microbiology (miscellaneous), Enos, Receptors, Opioid, delta, Lactate dehydrogenase, Internal medicine, Dietary Carbohydrates, medicine, lcsh:Pathology, Animals, Humans, Insulin, Obesity, Artery occlusion, Myocardial infarction, Phosphorylation, Cardioprotection, biology, business.industry, lcsh:R, medicine.disease, biology.organism_classification, Myocardial Contraction, Rats, Endocrinology, chemistry, Benzamides, Nitric Oxide Synthase, business, Protein Kinases, Reperfusion injury, Ex vivo, Signal Transduction, Research Article, lcsh:RB1-214 |
| الوصف: | Summary Obesity with associated metabolic disturbances worsens ischaemic heart disease outcomes, and rodent studies confirm that obesity with insulin-resistance impairs myocardial resistance to ischemia-reperfusion (I-R) injury. However, the effects of obesity per se are unclear, with some evidence for paradoxic cardioprotection (particularly in older subjects). We tested the impact of dietary obesity on I-R tolerance and reperfusion injury salvage kinase (RISK) signalling in hearts from middle-aged (10 months old) insulin-insensitive rats. Hearts from Wistar rats on either a 32-week control (CD) or high carbohydrate obesogenic (OB) diet were assessed for I-R resistance in vivo (45 minutes left anterior descending artery occlusion and 120 minutes reperfusion) and ex vivo (25 minutes ischemia and 60 minutes reperfusion). Expression and δ-opioid receptor (δ-OR) phospho-regulation of pro-survival (Akt/PKB, Erk1/2, eNOS) and pro-injury (GSK3β) enzymes were also examined. OB rats were heavier (764±25 versus 657±22 g for CD; P |
| اللغة: | English |
| تدمد: | 1754-8411 1754-8403 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::babdd7bca4693f9d7348172585e32988Test http://dmm.biologists.org/content/6/2/457Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....babdd7bca4693f9d7348172585e32988 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17548411 17548403 |
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