دورية أكاديمية
CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells
| العنوان: | CPP-Ts: a new intracellular calcium channel modulator and a promising tool for drug delivery in cancer cells |
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| المؤلفون: | Oliveira-Mendes, Bárbara Bruna Ribeiro de, Horta, Carolina Campolina Rebello, do Carmo, Anderson Oliveira, Biscoto, Gabriela Lago, Sales-Medina, Douglas Ferreira, Leal, Hortênsia Gomes, Brandão-Dias, Pedro Ferreira Pinto, Miranda, Sued Eustáquio Mendes, Aguiar, Carla Jeane, Cardoso, Valbert Nascimento, de Barros, André Luis Branco, Chávez-Olortégui, Carlos, Leite, M. Fátima, Kalapothakis, Evanguedes |
| المصدر: | Scientific Reports ; volume 8, issue 1 ; ISSN 2045-2322 |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Multidisciplinary |
| الوصف: | Scorpion sting envenoming impacts millions of people worldwide, with cardiac effects being one of the main causes of death on victims. Here we describe the first Ca 2+ channel toxin present in Tityus serrulatus ( Ts ) venom, a cell penetrating peptide (CPP) named CPP-Ts. We show that CPP-Ts increases intracellular Ca 2+ release through the activation of nuclear InsP3R of cardiomyocytes, thereby causing an increase in the contraction frequency of these cells. Besides proposing a novel subfamily of Ca 2+ active toxins, we investigated its potential use as a drug delivery system targeting cancer cell nucleus using CPP-Ts’s nuclear-targeting property. To this end, we prepared a synthetic CPP-Ts sub peptide 14–39 lacking pharmacological activity which was directed to the nucleus of specific cancer cell lines. This research identifies a novel subfamily of Ca 2+ active toxins and provides new insights into biotechnological applications of animal venoms. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1038/s41598-018-33133-3 |
| الإتاحة: | https://doi.org/10.1038/s41598-018-33133-3Test https://www.nature.com/articles/s41598-018-33133-3.pdfTest https://www.nature.com/articles/s41598-018-33133-3Test |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test ; https://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.2C17FCAA |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41598-018-33133-3 |
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