التفاصيل البيبلوغرافية
العنوان:
Common Genetic Variation In Cellular Transport Genes and Epithelial Ovarian Cancer (EOC) Risk
المؤلفون:
Ganna Chornokur , Hui-Yi Lin , Jonathan P Tyrer , Kate Lawrenson , Joe Dennis , Ernest K Amankwah , Xiaotao Qu , Ya-Yu Tsai , Heather S L Jim , Zhihua Chen , Ann Y Chen , Jennifer Permuth-Wey , Katja K H Aben , Hoda Anton-Culver , Natalia Antonenkova , Fiona Bruinsma , Elisa V Bandera , Yukie T Bean , Matthias W Beckmann , Maria Bisogna , Line Bjorge , Natalia Bogdanova , Louise A Brinton , Angela Brooks-Wilson , Clareann H Bunker , Ralf Butzow , Ian G Campbell , Karen Carty , Jenny Chang-Claude , Linda S Cook , Daniel W Cramer , Julie M Cunningham , Cezary Cybulski , Agnieszka Dansonka-Mieszkowska , Andreas du Bois , Evelyn Despierre , Ed Dicks , Jennifer A Doherty , Thilo Dörk , Matthias Dürst , Douglas F Easton , Diana M Eccles , Robert P Edwards , Arif B Ekici , Peter A Fasching , Brooke L Fridley , Yu-Tang Gao , Aleksandra Gentry-Maharaj , Graham G Giles , Rosalind Glasspool , Marc T Goodman , Jacek Gronwald , Patricia Harrington , Philipp Harter , Alexander Hein , Florian Heitz , Michelle A T Hildebrandt , Peter Hillemanns , Claus K Hogdall , Estrid Hogdall , Satoyo Hosono , Anna Jakubowska , Allan Jensen , Bu-Tian Ji , Beth Y Karlan , Linda E Kelemen , Mellissa Kellar , Lambertus A Kiemeney , Camilla Krakstad , Susanne K Kjaer , Jolanta Kupryjanczyk , Diether Lambrechts , Sandrina Lambrechts , Nhu D Le , Alice W Lee , Shashi Lele , Arto Leminen , Jenny Lester , Douglas A Levine , Dong Liang , Boon Kiong Lim , Jolanta Lissowska , Karen Lu , Jan Lubinski , Lene Lundvall , Leon F A G Massuger , Keitaro Matsuo , Valerie McGuire , John R McLaughlin , Iain McNeish , Usha Menon , Roger L Milne , Francesmary Modugno , Kirsten B Moysich , Roberta B Ness , Heli Nevanlinna , Ursula Eilber , Kunle Odunsi , Sara H Olson , Irene Orlow , Sandra Orsulic , Rachel Palmieri Weber , James Paul , Celeste L Pearce , Tanja Pejovic , Liisa M Pelttari , Malcolm C Pike , Elizabeth M Poole , Harvey A Risch , Barry Rosen , Mary Anne Rossing , Joseph H Rothstein , Anja Rudolph , Ingo B Runnebaum , Iwona K Rzepecka , Helga B Salvesen , Eva Schernhammer , Ira Schwaab , Xiao-Ou Shu , Yurii B Shvetsov , Nadeem Siddiqui , Weiva Sieh , Honglin Song , Melissa C Southey , Beata Spiewankiewicz , Lara Sucheston , Soo-Hwang Teo , Kathryn L Terry , Pamela J Thompson , Lotte Thomsen , Ingvild L Tangen , Shelley S Tworoger , Anne M van Altena , Robert A Vierkant , Ignace Vergote , Christine S Walsh , Shan Wang-Gohrke , Nicolas Wentzensen , Alice S Whittemore , Kristine G Wicklund , Lynne R Wilkens , Anna H Wu , Xifeng Wu , Yin-Ling Woo , Hannah Yang , Wei Zheng , Argyrios Ziogas , Hanis N Hasmad , Andrew Berchuck , Georgia Chenevix-Trench , AOCS management group , Edwin S Iversen , Joellen M Schildkraut , Susan J Ramus , Ellen L Goode , Alvaro N A Monteiro , Simon A Gayther , Steven A Narod , Paul D P Pharoah , Thomas A Sellers , Catherine M Phelan
المساهمون:
Agoulnik, Irina U, Department of Pathology, Medicum, Department of Obstetrics and Gynecology, Clinicum, HUS Gynecology and Obstetrics
المصدر:
PloS one, vol 10, iss 6
بيانات النشر:
Public Library of Sciene, 2015.
سنة النشر:
2015
مصطلحات موضوعية:
endocrine system diseases , lcsh:Medicine , Genome-wide association study , Carcinoma, Ovarian Epithelial , Bioinformatics , 0302 clinical medicine , 3123 Gynaecology and paediatrics , Neoplasms , Ovarian Epithelial , Odds Ratio , 2.1 Biological and endogenous factors , Neoplasms, Glandular and Epithelial , Aetiology , lcsh:Science , FAMILY SLC25 , Cancer , Ovarian Neoplasms , African Americans , 0303 health sciences , Multidisciplinary , Women's cancers Radboud Institute for Molecular Life Sciences [Radboudumc 17] , COLON-CANCER , Glandular and Epithelial , Single Nucleotide , 3. Good health , Ovarian Cancer , Serous fluid , Urological cancers Radboud Institute for Health Sciences [Radboudumc 15] , Female , HEPHAESTIN , Research Article , EXPRESSION , Risk , medicine.medical_specialty , CARCINOMA , General Science & Technology , 3122 Cancers , Single-nucleotide polymorphism , Biology , Polymorphism, Single Nucleotide , Georgia Chenevix-Trench , 03 medical and health sciences , Rare Diseases , Molecular genetics , medicine , Carcinoma , Genetics , SNP , BREAST-CANCER , Humans , Genetic Predisposition to Disease , Hormone transport , UDP-GLUCURONOSYLTRANSFERASES , GENOME-WIDE ASSOCIATION , Polymorphism , Alleles , Genetic Association Studies , 030304 developmental biology , Asian , lcsh:R , IRON TRANSPORT , Genetic Variation , Biological Transport , medicine.disease , POLYMORPHISM , Black or African American , Asian Americans , Case-Control Studies , Cancer research , lcsh:Q , 3111 Biomedicine , Ovarian cancer , AOCS management group , Carrier Proteins , 030217 neurology & neurosurgery
الوصف:
Contains fulltext : 154822.PDF (Publisher’s version ) (Open Access) BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. METHODS: In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q
وصف الملف:
Electronic-eCollection; application/pdf; text
اللغة:
English
تدمد:
1932-6203
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b2736deb859acb3df6fa00e6b6f117dTest http://dx.plos.org/10.1371/journal.pone.0128106Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....0b2736deb859acb3df6fa00e6b6f117d
قاعدة البيانات:
OpenAIRE
