التفاصيل البيبلوغرافية
| العنوان: |
Cardiac biomarkers retain prognostic significance in patients with heart failure and chronic obstructive pulmonary disease |
| المؤلفون: |
Vergaro, Giuseppe, Aimo, Alberto, Januzzi, James L., Richards, A. Mark, Lam, Carolyn S.P., Latini, Roberto, Staszewsky, Lidia, Anand, Inder S., Ueland, Thor, Rocca, Hans-Peter Brunner-La, Bayes-Genis, Antoni, Lupón, Josep, de Boer, Rudolf A., Yoshihisa, Akiomi, Takeishi, Yasuchika, Gustafsson, Ida, Eggers, Kai M., Huber, Kurt, Gamble, Greg D., Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze P., Troughton, Richard, Doughty, Robert N., Emdin, Michele, Passino, Claudio |
| المصدر: |
Journal of Cardiovascular Medicine ; volume 23, issue 1, page 28-36 ; ISSN 1558-2027 1558-2035 |
| بيانات النشر: |
Ovid Technologies (Wolters Kluwer Health) |
| سنة النشر: |
2021 |
| الوصف: |
Aims Chronic obstructive pulmonary disease (COPD) is a frequent comorbidity in patients with heart failure (HF). We assessed the influence of COPD on circulating levels and prognostic value of three HF biomarkers: N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity troponin T (hs-TnT), and soluble suppression of tumorigenesis-2 (sST2). Methods Individual data from patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values ( n = 8088) were analysed. A subgroup ( n = 3414) had also sST2 values. Results Patients had a median age of 66 years (interquartile interval 57–74), 77% were men and 82% had HF with reduced ejection fraction. NT-proBNP, hs-TnT and sST2 were 1207 ng/l (487–2725), 17 ng/l (9–31) and 30 ng/ml (22–44), respectively. Patients with COPD ( n = 1249, 15%) had higher NT-proBNP ( P = 0.042) and hs-TnT ( P < 0.001), but not sST2 ( P = 0.165). Over a median 2.0-year follow-up (1.5–2.5), 1717 patients (21%) died, and 1298 (16%) died from cardiovascular causes; 2255 patients (28%) were hospitalized for HF over 1.8 years (0.9–2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status. The best cut-offs from receiver-operating characteristics analysis were higher in patients with COPD than in those without. Patients with all three biomarkers higher than or equal to end-point- and COPD-status-specific cut-offs were also those with the worst prognosis. Conclusions Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.2459/jcm.0000000000001281 |
| DOI: |
10.2459/JCM.0000000000001281 |
| الإتاحة: |
https://doi.org/10.2459/jcm.0000000000001281Test |
| رقم الانضمام: |
edsbas.BBEB2466 |
| قاعدة البيانات: |
BASE |
