A Circulating MicroRNA Signature Capable of Assessing the Risk of Hepatocellular Carcinoma in Cirrhotic Patients
| العنوان: | A Circulating MicroRNA Signature Capable of Assessing the Risk of Hepatocellular Carcinoma in Cirrhotic Patients |
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| المؤلفون: | Kung-Hao Liang, Ya-Hui Huang, Po-Yuan Ke, Chih-Lang Lin, Kwang-Huei Lin, Tai-Long Pan, Tsung-Hui Hu, Chao-Wei Hsu, Rong-Nan Chien, Chau-Ting Yeh |
| المصدر: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-12 (2017) |
| بيانات النشر: | Nature Publishing Group UK, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Liver Cirrhosis, Male, medicine.medical_specialty, Carcinoma, Hepatocellular, Hepatitis C virus, Science, medicine.disease_cause, Gastroenterology, Risk Assessment, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, microRNA, Medicine, Humans, Circulating MicroRNA, Aged, Hepatitis B virus, Multidisciplinary, business.industry, Incidence (epidemiology), Liver Neoplasms, Reproducibility of Results, Middle Aged, medicine.disease, Prognosis, digestive system diseases, Cross-Sectional Studies, ROC Curve, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Cohort, Etiology, 030211 gastroenterology & hepatology, Female, business, Biomarkers |
| الوصف: | With the availability of potent antiviral therapies, complete suppression of hepatitis B virus (HBV) replication and total eradication of hepatitis C virus (HCV) can now be achieved. Despite these advances, hepatocellular carcinoma (HCC) still develops in a substantial proportion of cirrhotic patients, suggesting that host factors remain critical. Dysregulation of miRNAs is noted in many cancers, and circulating miRNAs can be readily assayed. In this study, we aimed to develop a circulating miRNA signature to assess the risk of HCC in cirrhotic patients. We first discovered that HBV- and HCV-related cirrhotic patients had distinguishable circulating miRNA profiles. A cohort of 330 cirrhotic patients was then compared against a cohort of 42 early HCC patients with complete remission. A score comprising 5 miRNAs and a binary etiology variable was established that was capable of differentiating between these two groups (AUC = 72.5%, P P = 0.038). In summary, a circulating miRNA-based score was developed that is capable of assessing HCC risks in cirrhotic patients. |
| اللغة: | English |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::188fabea9aa3f065c57d5b12c5b52c4aTest http://europepmc.org/articles/PMC5428873Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....188fabea9aa3f065c57d5b12c5b52c4a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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