دورية أكاديمية
The Brain at High Altitude: From Molecular Signaling to Cognitive Performance
| العنوان: | The Brain at High Altitude: From Molecular Signaling to Cognitive Performance |
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| المؤلفون: | Aboouf, Mostafa A, Thiersch, Markus, Soliz, Jorge, Gassmann, Max, Schneider Gasser, Edith M |
| المصدر: | Aboouf, Mostafa A; Thiersch, Markus; Soliz, Jorge; Gassmann, Max; Schneider Gasser, Edith M (2023). The Brain at High Altitude: From Molecular Signaling to Cognitive Performance. International Journal of Molecular Sciences, 24(12):10179. |
| بيانات النشر: | MDPI Publishing |
| سنة النشر: | 2023 |
| المجموعة: | University of Zurich (UZH): ZORA (Zurich Open Repository and Archive |
| مصطلحات موضوعية: | Neuroscience Center Zurich, Zurich Center for Integrative Human Physiology (ZIHP), Institute of Veterinary Physiology, 570 Life sciences, biology, Inorganic Chemistry, Organic Chemistry, Physical and Theoretical Chemistry, Computer Science Applications, Spectroscopy, Molecular Biology, General Medicine, Catalysis |
| الوصف: | The brain requires over one-fifth of the total body oxygen demand for normal functioning. At high altitude (HA), the lower atmospheric oxygen pressure inevitably challenges the brain, affecting voluntary spatial attention, cognitive processing, and attention speed after short-term, long-term, or lifespan exposure. Molecular responses to HA are controlled mainly by hypoxia-inducible factors. This review aims to summarize the cellular, metabolic, and functional alterations in the brain at HA with a focus on the role of hypoxia-inducible factors in controlling the hypoxic ventilatory response, neuronal survival, metabolism, neurogenesis, synaptogenesis, and plasticity. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| العلاقة: | https://www.zora.uzh.ch/id/eprint/234602/1/ZORA_pdf_version_1686823453.pdfTest; info:pmid/37373327; urn:issn:1422-0067 |
| DOI: | 10.5167/uzh-234602 |
| DOI: | 10.3390/ijms241210179 |
| الإتاحة: | https://doi.org/10.5167/uzh-23460210.3390/ijms241210179Test https://www.zora.uzh.ch/id/eprint/234602Test/ https://www.zora.uzh.ch/id/eprint/234602/1/ZORA_pdf_version_1686823453.pdfTest |
| حقوق: | info:eu-repo/semantics/openAccess ; Creative Commons: Attribution 4.0 International (CC BY 4.0) ; http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.5E0C36A3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 14220067 |
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| DOI: | 10.5167/uzh-234602 |