دورية أكاديمية
Urinary Biomarkers as a Proxy for Congenital Central Hypoventilation Syndrome Patient Follow-Up
| العنوان: | Urinary Biomarkers as a Proxy for Congenital Central Hypoventilation Syndrome Patient Follow-Up |
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| المؤلفون: | Marta Peruzzi, Matteo Ramazzotti, Roberta Damiano, Marzia Vasarri, Giancarlo la Marca, Cinzia Arzilli, Raffaele Piumelli, Niccolò Nassi, Donatella Degl'Innocenti |
| المصدر: | Antioxidants, Vol 11, Iss 929, p 929 (2022) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2022 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | CCHS, rare disease, oxidative stress, urinary biomarkers, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Congenital Central Hypoventilation Syndrome (CCHS) is a rare genetic disorder of the autonomic nervous system and in particular of the respiratory control during sleep. No drug therapy is, to date, available; therefore, the survival of these patients depends on lifelong ventilatory support during sleep. Reactive oxygen species (ROS)-induced oxidative stress is a recognized risk factor involved in the pathogenesis of several chronic diseases. Therefore, monitoring systemic oxidative stress could provide important insights into CCHS outcomes. Because ROS-induced oxidative products are excreted as stable metabolites in urine, we performed an HPLC-MS/MS analysis for the quantitative determination of the three main representative oxidative biomarkers (i.e., diY, MDA, and 8-OHdG) in the urine of CCHS patients. Higher levels of urinary MDA were found in CCHS patients compared with age-matched control subjects. The noteworthy finding is the identification of urinary MDA as relevant biomarker of systemic oxidative status in CCHS patients. This study is a concise and smart communication about the impact that oxidative stress has in CCHS, and suggests the monitoring of urinary MDA levels as a useful tool for the management of these patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-3921 |
| العلاقة: | https://www.mdpi.com/2076-3921/11/5/929Test; https://doaj.org/toc/2076-3921Test; https://doaj.org/article/50b93089472b4fee9576aa8aa421c28eTest |
| DOI: | 10.3390/antiox11050929 |
| الإتاحة: | https://doi.org/10.3390/antiox11050929Test https://doaj.org/article/50b93089472b4fee9576aa8aa421c28eTest |
| رقم الانضمام: | edsbas.DB52AF4D |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20763921 |
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| DOI: | 10.3390/antiox11050929 |