Radiosensitization of Hepatocellular Carcinoma through Targeting Radio-Associated MicroRNA
| العنوان: | Radiosensitization of Hepatocellular Carcinoma through Targeting Radio-Associated MicroRNA |
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| المؤلفون: | Kwang-Huei Lin, Cheng Yi Chen, Chau Ting Yeh, Cheng Heng Wu |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 21, Iss 5, p 1859 (2020) |
| بيانات النشر: | MDPI, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Carcinoma, Hepatocellular, DNA Repair, DNA repair, medicine.medical_treatment, Review, medicine.disease_cause, Radiation Tolerance, Catalysis, Metastasis, lcsh:Chemistry, Inorganic Chemistry, liver cancer, microRNA, medicine, Animals, Humans, Physical and Theoretical Chemistry, lcsh:QH301-705.5, Molecular Biology, 3' Untranslated Regions, Spectroscopy, business.industry, Organic Chemistry, Liver Neoplasms, apoptosis, Cancer, General Medicine, Cell cycle, medicine.disease, Computer Science Applications, Radiation therapy, radiation, MicroRNAs, lcsh:Biology (General), lcsh:QD1-999, Cancer research, DNA damage, cell cycle, Liver cancer, Carcinogenesis, business, Signal Transduction |
| الوصف: | Hepatocellular carcinoma (HCC) is the fourth leading cause of cancer-related deaths worldwide. For patients who are resistant to monotherapy, multimodal therapy is a basic oncologic principle that incorporates surgery, radiotherapy (RT), and chemotherapy providing survival benefits for patients with most types of cancer. Although liver has low tolerance for radiation, high-precision RT for local HCC minimizes the likelihood of radiation-induced liver disease (RILD) in noncancerous liver tissue. RT have several therapeutic benefits, including the down-staging of tumors to make them resectable and repression of metastasis. The DNA damage response (DDR) is a cellular response to irradiation (IR), including DNA repair of injured cells and induction of programmed cell death, thereby resulting in maintenance of cell homeostasis. Molecules that block the activity of proteins in DDR pathways have been found to enhance radiotherapeutic effects. These molecules include antibodies, kinase inhibitors, siRNAs and miRNAs. MicroRNAs (miRNAs) are short non-coding regulatory RNAs binding to the 3′-untranslated regions (3′-UTR) of the messenger RNAs (mRNAs) of target genes, regulating their translation and expression of proteins. Thus, miRNAs and their target genes constitute complicated interactive networks, which interact with other molecules during carcinogenesis. Due to their promising roles in carcinogenesis, miRNAs were shown to be the potential factors that mediated radiosensitivity and optimized outcomes of the combination of systemic therapy and radiotherapy. |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae2ad9d7e1d3181ca4314100083eb1cTest http://europepmc.org/articles/PMC7084923Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3ae2ad9d7e1d3181ca4314100083eb1c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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