التفاصيل البيبلوغرافية
| العنوان: |
The role of GABA A receptors in the analgesic effect of intra-paragigantocellularis lateralis injection of 17β-estradiol in male rat. |
| المؤلفون: |
Khakpay, Roghaieh1 rkhakpai@gmail.com, Azaddar, Maryam1, Khakpay, Fatemeh2, Hatami Nemati, Homeira1 |
| المصدر: |
Physiology & Pharmacology. 2015, Vol. 19, p99-106. 8p. |
| مصطلحات موضوعية: |
*GABA agents, *ALLOSTERIC regulation, *ESTRADIOL |
| مستخلص: |
Introduction: 17β-Estradiol modulates nociception by binding to the estrogenic receptors and also by allosteric interaction with other membrane-bound receptors like glutamate and GABA A receptors. In addition to its autonomic functions, paragigantocellularis lateralis (LPGi) is involved in the pain modulation, too. The aim of the current study was to investigate the involvement of the membrane-bound GABA A receptors in the pain modulatory effect of intra-LPGi injection of 17β-estradiol of male rats. Materials and Methods: This study was performed using male Wistar rats in the range of 200-270 g. In order to investigate the antinociceptive effect of intra-LPGi microinjection of 17β-estradiol, cannulation into the LPGi nucleus was performed. 500 nl of drugs were administered 15 minutes prior to formalin injection (50 µl of 4%). Then, formalin-induced paw jerking behaviour was recorded for 60 min. For assessing the role of the GABAA receptors in the estradiol induced pain modulation, 17β-estradiol was administered into the LPGi nucleus 15 min after the injection of 25 ng/µl bicuculline; and paw jerking frequency was recorded for 1 h. Results: The results of the current study showed that intra-LPGi injection of 0.8 µmol of 17β-estradiol attenuated the chronic phase (P<0.001) of paw jerking behaviour. Bicuculine -the GABA A receptor antagonist-significantly reduced the antinociceptive effect of intra-LPGi 17β-estradiol in the chronic phase (P<0.001). Conclusion: It may be concluded that the analgesic effect of intra-LPGi injection of 17β-estradiol on the formalin-induced inflammatory pain might be mediated via GABAA receptors. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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