المؤلفون: Posada, Itziar M. D., Lectez, Benoit, Sharma, Mukund, Oetken-Lindholm, Christina, Yetukuri, Laxman, Zhou, Yong, Aittokallio, Tero, Abankwa, Daniel

المساهمون: Institute for Molecular Medicine Finland, University of Helsinki, Tero Aittokallio / Principal Investigator, Bioinformatics

مصطلحات موضوعية: mTORC1, Ras, rapamycin, galectin, cancer stem cells, K-RAS, MEMBRANE ORIENTATION, MTOR INHIBITORS, PROTEINS, TARGET, MODEL, HRAS, NANOCLUSTERS, METASTASIS, ACTIVATION, 3122 Cancers

وصف الملف: application/pdf

العلاقة: This work was supported by the Academy of Finland grants (#292611) to TA and (#252381, 256440, 281497), the Sigrid Juselius Foundation, and the Jane and Aatos Erkko Foundation grants to DA. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.; Posada , I M D , Lectez , B , Sharma , M , Oetken-Lindholm , C , Yetukuri , L , Zhou , Y , Aittokallio , T & Abankwa , D 2017 , ' Rapalogs can promote cancer cell stemness in vitro in a Galectin-1 and H-ras-dependent manner ' , Oncotarget , vol. 8 , no. 27 , pp. 44550-44566 . https://doi.org/10.18632/oncotarget.17819Test; ORCID: /0000-0002-0886-9769/work/41148402; 85021842962; 83ccf1c4-6e75-477a-acba-e7edce16c74d; http://hdl.handle.net/10138/214063Test; 000405498000078

الإتاحة: http://hdl.handle.net/10138/214063Test

المؤلفون: Franco Cortese, Darla Karpinsky-Semper, Alex Zhavoronkov, Leslie C. Jellen, Alexander Aliper, Artem V. Artemov, Andrew G. Swick, Alexey Moskalev

المصدر: Aging (Albany NY)

مصطلحات موضوعية: 0301 basic medicine, Aging, Computational biology, compound screening, Machine Learning, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Databases, Genetic, Drug Discovery, Screening method, Medicine, Humans, Gene Regulatory Networks, Molecular Targeted Therapy, Protein Interaction Maps, Protein Kinase Inhibitors, natural, Sirolimus, Molecular Structure, business.industry, rapamycin, TOR Serine-Threonine Kinases, Molecular Mimicry, deep learning, Computational Biology, Cell Biology, Experimental validation, Geroprotector, Discovery and development of mTOR inhibitors, Metformin, High-Throughput Screening Assays, 030104 developmental biology, Chronic disease, chemistry, 030220 oncology & carcinogenesis, Dietary Supplements, geroprotector, nutraceutical, Neural Networks, Computer, business, Isoliquiritigenin, medicine.drug, Research Paper, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4085f985e3077bd427a25233052bfc2bTest
http://europepmc.org/articles/PMC5723685Test

المؤلفون: Sajjad Hussain, Paul J. Galardy, Tibor Bedekovics

المصدر: Oncotarget

مصطلحات موضوعية: Oncogene, protein synthesis, animal model, lymphoma, Biology, medicine.disease, Discovery and development of mTOR inhibitors, Lymphoma, Animal model, medicine.anatomical_structure, Editorial, Oncology, Protein biosynthesis, medicine, Cancer research, B cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::293de77e4224ce63a19fa49c03a919e8Test
http://europepmc.org/articles/PMC6718265Test

المؤلفون: Christos Demosthenous, Eduardo M. Sotomayor, Matthew J. Maurer, Brian K. Link, Ahmet Dogan, Mamta Gupta, Linda Wellik, Kristen Hege, Thomas E. Witzig, Jing Jing Han, Mary Stenson

المصدر: Oncotarget

مصطلحات موضوعية: Aggressive lymphoma, Cell Cycle Proteins, CC214-1, Eukaryotic initiation factor 4F, chemistry.chemical_compound, 0302 clinical medicine, Molecular Targeted Therapy, RNA, Neoplasm, Cyclin D3, Phosphorylation, RNA, Small Interfering, Tumor Stem Cell Assay, 0303 health sciences, dual mTOR inhibitors, Hematology, EIF4G, TOR Serine-Threonine Kinases, EIF4E, Imidazoles, 3. Good health, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, Pyrazines, RNA Interference, Lymphoma, Large B-Cell, Diffuse, Translation initiation complex, Research Paper, RNA Caps, medicine.medical_specialty, lymphoma, Biology, Proto-Oncogene Proteins c-myc, 03 medical and health sciences, Internal medicine, Cell Line, Tumor, medicine, Humans, Neoplasm Invasiveness, Protein Kinase Inhibitors, 030304 developmental biology, Adaptor Proteins, Signal Transducing, medicine.disease, Phosphoproteins, Lymphoma, Eukaryotic Initiation Factor-4E, HEK293 Cells, chemistry, Eukaryotic Initiation Factor-4F, eIF4E, Protein Biosynthesis, Cancer research, Eukaryotic Initiation Factor-4G, Diffuse large B-cell lymphoma, Protein Processing, Post-Translational, translation initiation complex

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a65b53807ffed20b5e09b573edda0d9Test
http://europepmc.org/articles/PMC4496233Test

المؤلفون: Jennifer J. Wheler, David S. Hong, Aung Naing, Philip James Stephens, Apostolia Maria Tsimberidou, Razelle Kurzrock, Bettzy Stephen, Roman Yelensky, Filip Janku, Stephen G. Swisher, Gerald S. Falchook, Thorunn Helgason

المصدر: Oncotarget

مصطلحات موضوعية: Oncology, Adult, Male, medicine.medical_specialty, mTOR inhibitors, Thymoma, medicine.medical_treatment, Targeted therapy, Internal medicine, medicine, Humans, Protein Kinase Inhibitors, Thymic carcinoma, Survival analysis, Aged, Retrospective Studies, response, business.industry, Medical record, TOR Serine-Threonine Kinases, Retrospective cohort study, Middle Aged, medicine.disease, targeted therapy, Research Papers, Survival Analysis, United States, Surgery, Clinical trial, Regimen, Female, business, thymic carcinoma, advanced thymoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d1e4f0170d2ec67746800a7a042bd83Test
http://europepmc.org/articles/PMC3757246Test

المؤلفون: Günter Schneider, Philipp Eser, Roland M. Schmid, Dieter Saur, Philipp Pagel, Stefan Eser, Barbara Seidler, Marlena Messer, Melanie Szameitat, Maximilian Reichert, Mariel C. Paul, Patrick Wenzel, Sandra Diersch, Irene Esposito

المصدر: Oncotarget
Web of Science

مصطلحات موضوعية: endocrine system diseases, pancreatic cancer, Cell Growth Processes, Biology, P110α, medicine.disease_cause, Transfection, PI3K, Efemp1, Mice, Pancreatic cancer, Cell Line, Tumor, medicine, Carcinoma, Animals, Humans, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Mice, Knockout, Extracellular Matrix Proteins, Kinase, TOR Serine-Threonine Kinases, Cancer, p27, medicine.disease, Discovery and development of mTOR inhibitors, Xenograft Model Antitumor Assays, digestive system diseases, Pancreatic Neoplasms, Disease Models, Animal, Oncology, Immunology, Cancer research, Bez235, KRAS, Phosphatidylinositol 3-Kinase, Cyclin-Dependent Kinase Inhibitor p27, Research Paper, Carcinoma, Pancreatic Ductal, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8754d7d4776682fd83a8f533c9cfce2eTest
http://europepmc.org/articles/PMC3712573Test

المؤلفون: Liangliang Wu, Hao Wu, Hongyu Jiang, Meiqing Lou, Jinying Zhang, Fei Shi, Tianyi Liu, Qiyan Wu, Hongyu Liu

المصدر: Oncotarget

مصطلحات موضوعية: Antitumor activity, Text mining, Oncology, In vivo, Chemistry, business.industry, Cancer research, Correction, DUAL (cognitive architecture), business, Discovery and development of mTOR inhibitors, PI3K/AKT/mTOR pathway, In vitro

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea2e26d46c6807856e5c81a06fa2bb41Test
http://europepmc.org/articles/PMC5908321Test

المؤلفون: Zhavoronkov, Alexander

المصدر: Oncotarget

مصطلحات موضوعية: mTOR inhibitors, mTOR, Rapamycin, News, gerosuppression

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::5989124d9f5bc2a609bee873cb7dd475Test
http://europepmc.org/articles/PMC4792609Test