التفاصيل البيبلوغرافية
| العنوان: |
Transarterial Chemoembolization of Metastatic Colorectal Carcinoma with Drug-Eluting Beads, Irinotecan (DEBIRI): Multi-Institutional Registry. |
| المؤلفون: |
Martin, Robert C. G., Joshi, Jonathan, Robbins, Ken, Tomalty, Dana, O'Hara, Ryan, Tatum, Cliff |
| المصدر: |
Journal of Oncology; 2009, p1-6, 6p, 1 Chart |
| مصطلحات موضوعية: |
COLON cancer treatment, DRUG therapy, THERAPEUTICS, DRUG side effects, MEDIAN (Mathematics), RESPONSE rates, TUMOR treatment, CANCER treatment, DRUG administration, EDUCATION |
| مستخلص: |
The purpose of this study was to evaluate the patient tolerance and efficacy of delivering locoregional chemotherapy to metastatic colorectal (MC) hepaticmetastases via hepatic trans-arterial approach using irinotecan loaded drug eluting beads. This open-label, multi-center, single arm study included 30 MC patients, who had failed first line therapy. Of the 57 total embolization sessions, 12 (21% of sessions) were associated with adverse reactions during or after the treatment. After a median followup of 9 months, response rates by modified RECIST were 75% at 3 months and 66% at 6 months. Hepatic trans-arterial therapy using Irinotecan loaded DC Bead™ was safe and effective in the treatment of MCC as demonstrated by a minimal complication rate and acceptable tumor response. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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