دورية أكاديمية
Expression of hMSH2 and hMLH1 in Colorectal Carcinomas with Microsatellite Instability
| العنوان: | Expression of hMSH2 and hMLH1 in Colorectal Carcinomas with Microsatellite Instability |
|---|---|
| المساهمون: | Hoguen Kim, Zhe Piao, Jae Woo Kim, Jin Sub Choi, Nam Kyu Kim, Jae Myun Lee, Jeon-Han Park, Kim, Nam Kyu |
| بيانات النشر: | Gustav Fischer Verlag |
| سنة النشر: | 1998 |
| مصطلحات موضوعية: | Adaptor Proteins, Signal Transducing, Adult, Aged, Blotting, Western, Carrier Proteins, Colorectal Neoplasms/genetics, Colorectal Neoplasms/metabolism, Colorectal Neoplasms/pathology, DNA Repair/genetics, DNA, Neoplasm/analysis, DNA-Binding Proteins, Female, Gene Expression Regulation, Neoplastic/genetics, Humans, Immunohistochemistry, Male, Microsatellite Repeats, Middle Aged, MutL Protein Homolog 1, MutS Homolog 2 Protein, Neoplasm Proteins/genetics, Neoplasm Proteins/metabolism, Nuclear Proteins, Polymerase Chain Reaction, Proto-Oncogene Proteins/genetics, Proto-Oncogene Proteins/metabolism |
| الوصف: | Warty carcinoma of the uterine cervix is a very rare specific variant of invasive squamous cell carcinoma, usually described as a hybrid feature of condyloma with invasive squamous cell carcinoma. Besides having the koilocytes and maturation of squamous epithelium, there is unequivocal stromal invasion. The feathery surface seems to be characteristic of warty carcinoma, differentiating it from condylomata acuminata or verrucous carcinoma. Using in situ polymerase chain reaction (IS-PCR) and in situ hybridization (ISH) as well as an immunohistochemical technique (IHC), we determined the amplification and expression of several human papilloma virus (HPV) types (6, 11, 33, 16 and 18) in nine warty carcinomas of the uterine cervix. We found amplified HPV predominantly in the nuclei of the feathery surface in all cases only when IS-PCR was applied, while it was detected only in five (55.6%) or six cases (66.7%) by conventional IHC or ISH, respectively. We found multiple types in the same lesion in six cases (66.7%) by IS-PCR, in comparison with ISH which detected a lower incidence (22.2%). This finding of coinfection is more consistent with that seen in low-grade squamous intraepithelial lesions (LSILs) of the uterine cervix than in high SIL. It is important to be aware of these distinct lesions in postmenopausal women with their characteristic feathery and thin surface, as well as a hybrid form of exophytic condyloma and stromal invasion, and frequent coinfection of multiple different HPVs as a type of LSILs. ; restriction |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English German French |
| تدمد: | 0344-0338 1618-0631 |
| العلاقة: | PATHOLOGY RESEARCH AND PRACTICE; J02474; OAK-1998-00021; https://ir.ymlib.yonsei.ac.kr/handle/22282913/176292Test; 9542742; http://www.sciencedirect.com/science/article/pii/S0344033898801313Test; T199800396; PATHOLOGY RESEARCH AND PRACTICE, Vol.194(1) : 3-9, 1998 |
| DOI: | 10.1016/S0344-0338(98)80131-3 |
| الإتاحة: | https://doi.org/10.1016/S0344-0338Test(98)80131-3 https://ir.ymlib.yonsei.ac.kr/handle/22282913/176292Test http://www.sciencedirect.com/science/article/pii/S0344033898801313Test |
| حقوق: | CC BY-NC-ND 2.0 KR |
| رقم الانضمام: | edsbas.5396A0EF |
| قاعدة البيانات: | BASE |
| تدمد: | 03440338 16180631 |
|---|---|
| DOI: | 10.1016/S0344-0338(98)80131-3 |