المؤلفون: Fernández-Huertas Moraga, Jesús, Ferrer-i-Carbonell, Ada, Saiz, Albert

المساهمون: Ministerio de Economía y Competitividad (España), Comunidad de Madrid

مصطلحات موضوعية: International migration, Native flight, Residential segregation, F22, J61, D33, Economía

الوصف: Strong political movements voicing opposition to immigration are on the upswing. Does such potential antagonism translate into residential dynamics? We study whether natives ed from immigrant areas in reaction to the largest and fastest migration shock in the OECD. The in ow{causing the population of Spain to grow by 10 percent between 1998 and 2008{represented a largely new phenomenon, the size of which had not been factored into previous expectations, thereby providing quasi-experimental sources of variance. Our results show that immigrant in ows caused mild native displacement from denser, established neighborhoods, but also more real estate development in these areas. In parallel, both natives and immigrants were collocating in booming suburban communities, resulting in no changes to overall measures of ethnic segregation. In light of the results, we argue that whenever ethnic-minority arrivals spur the creation of new neighborhoods, conventional empirical methods overstate the degree of native fight. ; Jesús Fernández-Huertas Moraga gratefully acknowledges the support from the Ministerio de Econom a, Industria y Competitividad (Spain), grants ECO2016-76402-R and MDM 2014-0431, and from the Comunidad de Madrid, MadEco-CM (S2015/HUM-3444).

العلاقة: Comunidad de Madrid. S2015/HUM-3444; Gobierno de España. ECO2016-76402-R; Gobierno de España. MDM 2014-0431; Fernández-Huertas Moraga, J., Ferrer-i-Carbonell, A., & Saiz, A. (2019). Immigrant locations and native residential preferences: Emerging ghettos or new communities? Journal of Urban Economics, 112, pp. 133-151.; http://hdl.handle.net/10016/35136Test; https://doi.org/10.1016/j.jue.2019.06.002Test; 133; 151; JOURNAL OF URBAN ECONOMICS; 112; AR/0000024996

الإتاحة: https://doi.org/10.1016/j.jue.2019.06.002Test
http://hdl.handle.net/10016/35136Test

المؤلفون: Ramió i Torrentà, Lluís, Álvarez Cermeño, José Carlos, Arroyo, R., Casanova Estruch, Bonaventura, Fernández, Óscar, García Merino, Juan Antonio, Hernández, M.A., Izquierdo, Guillermo, Martínez Yélamos, Sergio, Meca Lallana, José E., Moral, E., Olascoaga, Javier, Prieto, J.M., Saiz, Albert

المصدر: © Neurologia, 2018, vol. 33, núm. 5, p. 327-337 ; Articles publicats (IdIBGi)

مصطلحات موضوعية: Esclerosi múltiple -- Tractament, Multiple sclerosis -- Treatment

الوصف: Gait impairment, a frequent sign in multiple sclerosis (MS), places a major burden on patients since it results in progressive loss of personal and social autonomy, along with work productivity. This guide aims to provide recommendations on how to evaluate gait impairment and use prolonged-release fampridine (PR-fampridine) as treatment for MS patients with gait impairment in Spain. Development: PR-fampridine dosed at 10 mg every 12 hours is currently the only drug approved to treat gait impairment in adults with MS. Additionally, PR-fampridine has been shown in clinical practice to significantly improve quality of life (QoL) in patients who respond to treatment. Treatment response can be assessed with the Timed 25-Foot Walk (T25FW) or the 12-item MS Walking Scale (MSWS-12); tests should be completed before and after starting treatment. The minimum time recommended for evaluating treatment response is 2 weeks after treatment onset. Patients are considered responders and permitted to continue the treatment when they demonstrate a decrease in their T25FW time or an increase in MSWS-12 scores. A re-evaluation is recommended at least every 6 months. The SF-36 (Short Form-36) and the MSIS-29 (MS Impact Scale-29) tests are recommended for clinicians interested in performing a detailed QoL assessment. This drug is generally well-tolerated and has a good safety profile. It should be taken on an empty stomach and renal function must be monitored regularly. Conclusions: These recommendations will help ensure safer and more efficient prescription practices and easier management of PR-fampridine as treatment for gait impairment in Spanish adults with MS

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/issn/0213-4853; info:eu-repo/semantics/altIdentifier/eissn/1578-1968; http://hdl.handle.net/10256/16515Test

الإتاحة: https://doi.org/10.1016/j.nrl.2015.11.013Test
http://hdl.handle.net/10256/16515Test

المؤلفون: Keshavan, Anisha, Paul, Friedemann, Beyer, Mona K., Zhu, Alyssa H., Papinutto, Nico, Shinohara, Russell T., Stern, William, Amann, Michael, Bakshi, Rohit, Bischof, Antje, Carriero, Alessandro, Comabella, Manuel, Crane, Jason C., d'Alfonso, Sandra, Demaerel, Philippe, Dubois, Benedicte, Filippi, Massimo, Fleischer, Vinzenz, Fontaine, Bertrand, Gaetano, Laura, Goris, An, Graetz, Christiane, Gröger, Adriane, Groppa, Sergiu, Hafler, David A., Harbo, Hanne F., Hemmer, Bernhard, Jordan, Kesshi, Kappos, Ludwig, Kirkish, Gina, Llufriu, Sara, Magon, Stefano, Martinelli-Boneschi, Filippo, Mccauley, Jacob L., Montalban, Xavier, Mühlau, Mark, Pelletier, Daniel, Pattany, Pradip M., Pericak-Vance, Margaret, Cournu-Rebeix, Isabelle, Rocca, Maria A., Rovira, Alex, Schlaeger, Regina, Saiz, Albert, Sprenger, Till, Stecco, Alessandro, Uitdehaag, Bernard M.J., Villoslada, Pablo, Wattjes, Mike P., Weiner, Howard, Wuerfel, Jens, Zimmer, Claus, Zipp, Frauke, Hauser, Stephen L., Oksenberg, Jorge R., Henry, Roland G.

المساهمون: Bioengineering Graduate Program (joint degree with UCSF), Department of Bioengineering Berkeley, University of California Berkeley (UC Berkeley), University of California (UC)-University of California (UC)-University of California Berkeley (UC Berkeley), University of California (UC)-University of California (UC)-University of California San Francisco (UC San Francisco), University of California (UC), Department of Neurology San Francisco, University of California San Francisco (UC San Francisco), University of California (UC)-University of California (UC), Max Delbrueck Centre for Molecular Medicine, NeuroCure Clinical Research Center and Clinical and Experimental Multiple Sclerosis Research Center, Charité - UniversitätsMedizin = Charité - University Hospital Berlin, Department of Radiology and Nuclear Medicine, Oslo University Hospital Oslo, Department of Biostatistics and Epidemiology Philadelphia, Perelman School of Medicine, University of Pennsylvania-University of Pennsylvania, Department of Neurology Suisse, University Hospital Basel Basel, Medical Image Analysis Center (MIAC AG), Brigham and Women's Hospital Boston, Clinical Immunology, Department of Translational Medicine, UPO University, Vall d'Hebron University Hospital Barcelona, Department of Radiology and Biomedical Imaging San Francisco, Department of Health Sciences, UPO University, Department of Radiology Leuven, University Hospitals Leuven Leuven, Department of Neurosciences Leuven, University of Leuven K.U.Leuven, Institute of Experimental Neurology, Milan, Johannes Gutenberg - Universität Mainz = Johannes Gutenberg University (JGU), Focus Program Translational Neuroscience (FTN) and Immunotherapy (FZI), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Departments of Neurology and Immunobiology Yale, Yale School of Medicine New Haven, Connecticut (YSM), Department of Neurology Oslo, Akershus University Hospital Lørenskog, Klinikum rechts der Isar (MRI TUM), Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM), Munich Cluster of Systems Neurology (SyNery), Center for Neuroimmunology, Service of Neurology, Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Neuroimaging Research Unit, Scientific Institute and University Hospital San Raffaele, Milan, John P. Hussman Institute for Human Genomics, University of Miami Leonard M. Miller School of Medicine (UMMSM), Department of Radiology Miami, DKD Helios Klinik Wiesbaden, Section of Neuroradiology Novara, Maggiore Hospital, VU University Medical Center Amsterdam, Dept Neuroradiology Munich, Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM)-Technische Universität Munchen - Technical University Munich - Université Technique de Munich (TUM)

المصدر: ISSN: 1053-8119.

مصطلحات موضوعية: [INFO.INFO-IM]Computer Science [cs]/Medical Imaging

الوصف: International Multiple Sclerosis Genetics Consortium ; International audience ; A concern for researchers planning multisite studies is that scanner and T1-weighted sequence-related biases on regional volumes could overshadow true effects, especially for studies with a heterogeneous set of scanners and sequences. Current approaches attempt to harmonize data by standardizing hardware, pulse sequences, and protocols, or by calibrating across sites using phantom-based corrections to ensure the same raw image intensities. We propose to avoid harmonization and phantom-based correction entirely. We hypothesized that the bias of estimated regional volumes is scaled between sites due to the contrast and gradient distortion differences between scanners and sequences. Given this assumption, we provide a new statistical framework and derive a power equation to define inclusion criteria for a set of sites based on the variability of their scaling factors. We estimated the scaling factors of 20 scanners with heterogeneous hardware and sequence parameters by scanning a single set of 12 subjects at sites across the United States and Europe. Regional volumes and their scaling factors were estimated for each site using Freesurfer's segmentation algorithm and ordinary least squares, respectively. The scaling factors were validated by comparing the theoretical and simulated power curves, performing a leave-one-out calibration of regional volumes, and evaluating the absolute agreement of all regional volumes between sites before and after calibration. Using our derived power equation, we were able to define the conditions under which harmonization is not necessary to achieve 80% power. This approach can inform choice of processing pipelines and outcome metrics for multisite studies based on scaling factor variability across sites, enabling collaboration between clinical and research institutions.

العلاقة: hal-01311572; https://hal.sorbonne-universite.fr/hal-01311572Test; https://hal.sorbonne-universite.fr/hal-01311572/documentTest; https://hal.sorbonne-universite.fr/hal-01311572/file/1-s2.0-S1053811916002561-main.pdfTest

الإتاحة: https://doi.org/10.1016/j.neuroimage.2016.03.051Test
https://hal.sorbonne-universite.fr/hal-01311572Test
https://hal.sorbonne-universite.fr/hal-01311572/documentTest
https://hal.sorbonne-universite.fr/hal-01311572/file/1-s2.0-S1053811916002561-main.pdfTest

المؤلفون: Solana, Elisabeth, Martinez-Heras, Eloy, Martinez-Lapiscina, Elena H., Sepulveda, Maria, Sola-Valls, Nuria, Bargalló, Nuria, Berenguer, Joan, Blanco, Yolanda, Andorra, Magi, Pulido-Valdeolivas, Irene, Zubizarreta, Irati, Saiz, Albert, Llufriu, Sara

مصطلحات موضوعية: Regular Article, psy

الوصف: Patients with multiple sclerosis (MS) display reduced structural connectivity among brain regions, but the pathogenic mechanisms underlying network disruption are still unknown. We aimed to investigate the association between the loss of diffusion-based structural connectivity, measured with graph theory metrics, and magnetic resonance (MR) markers of microstructural damage. Moreover, we evaluated the cognitive consequences of connectivity changes. We analysed the frontoparietal network in 102 MS participants and 25 healthy volunteers (HV). MR measures included radial diffusivity (RD), as marker of demyelination, and ratios of myo-inositol, N-acetylaspartate and glutamate+glutamine with creatine in white (WM) and grey matter as markers of astrogliosis, neuroaxonal integrity and glutamatergic neurotoxicity. Patients showed decreased global and local efficiency, and increased assortativity (p < 0.01) of the network, as well as increased RD and myo-inositol, and decreased N-acetylaspartate in WM compared with HV (p < 0.05). In patients, the age-adjusted OR of presenting abnormal global and local efficiency was increased for each increment of 0.01 points in RD and myo-inositol, while it was decreased for each increment of 0.01 points in N-acetylaspartate (the increase of N-acetylaspartate reduced the risk of having abnormal connectivity), all in WM. In a multiple logistic regression analysis, the OR of presenting abnormal global efficiency was 0.95 (95% confidence interval, CI: 0.91–0.99, p = 0.011) for each 0.01 increase in N-acetylaspartate, and the OR of presenting abnormal local efficiency was 1.39 (95% CI: 1.14–1.71, p = 0.001) for each 0.01 increase in RD. Patients with abnormal efficiency had worse performance in attention, working memory and processing speed (p < 0.05). In conclusion, patients with MS exhibit decreased structural network efficiency driven by diffuse microstructural impairment of the WM, probably related to demyelination, astroglial and neuroaxonal damage. The accumulation of .

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072676Test/

الإتاحة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072676Test/

المؤلفون: Glaeser, Edward, Gyourko, Joseph, Saiz, Albert

مصطلحات موضوعية: archi, envir

الوصف: Like many other assets, housing prices are quite volatile relative to observable changes in fundamentals. If we are going to understand boom-bust housing cycles, we must incorporate housing supply. In this paper, we present a simple model of housing bubbles that predicts that places with more elastic housing supply have fewer and shorter bubbles, with smaller price increases. However, the welfare consequences of bubbles may actually be higher in more elastic places because those places will overbuild more in response to a bubble. The data show that the price run-ups of the 1980s were almost exclusively experienced in cities where housing supply is more inelastic. More elastic places had slightly larger increases in building during that period. Over the past five years, a modest number of more elastic places also experienced large price booms, but as the model suggests, these booms seem to have been quite short. Prices are already moving back towards construction costs in those areas. ; Economics

العلاقة: http://nrs.harvard.edu/urn-3:HUL.InstRepos:2962640Test

الإتاحة: http://nrs.harvard.edu/urn-3:HUL.InstRepos:2962640Test