دورية أكاديمية
Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific
| العنوان: | Ethnic differences in atrial fibrillation in patients with heart failure from Asia-Pacific |
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| المؤلفون: | Tan, Eugene S J, Tay, Wan Ting, Teng, Tiew-Hwa Katherine, Sim, David, Leong, Kui Toh Gerard, Yeo, Poh Shuan Daniel, Ong, Hean Yee, Jaufeerally, Fazlur, Ng, Tze Pin, Poppe, Katrina, Lund, Mayanna, Devlin, Gerard, Troughton, Richard W, Ling, Lieng Hsi, Richards, Arthur Mark, Doughty, Robert N, Lam, Carolyn S P |
| بيانات النشر: | BMJ Publishing Group Ltd |
| سنة النشر: | 2019 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | Heart failure and cardiomyopathies |
| الوصف: | Objective Ethnic differences in the prevalence of atrial fibrillation (AF) in heart failure (HF) remain unclear. We compared the prevalence and clinical correlates of AF among different ethnicities in an Asian-Pacific population with HF. Methods Patients with validated HF were prospectively studied across Singapore and New Zealand (NZ). Results Among 1746 patients with HF (62% Asian, 26% women, mean age 66 (SD 13) years, mean ejection fraction (EF) 37 (SD 16%), 39% had AF. The prevalence of AF was markedly lower in Singapore-Asians than NZ-Europeans (24% vs 63%; p<0.001), even after adjusting for age, clinical and echocardiographic covariates, regardless of EF group (p interaction for EF=0.39). Patients with AF were older, had higher body mass index and were more likely to have a history of hypertension, stroke, peripheral vascular disease, renal disease, chronic respiratory disease and increased alcohol intake, but less likely to have diabetes. Clinical correlates were similar for Asians and NZ-Europeans, except diabetes: Asian diabetic patients with HF had less AF compared with Asian patients without diabetes (OR 0.66, 95% CI 0.50 to 0.88), whereas among NZ-Europeans there was no significant association between diabetes and AF (OR 1.22, 95% CI 0.85 to 1.75) (p interaction for ethnicity=0.01). AF was associated with a higher crude composite outcome of mortality and HF hospitalisations at 2 years (HR 1.19, 95% CI 1.02 to 1.38). Conclusion There is a strikingly lower prevalence of AF among Asian compared with NZ-European patients with HF. The underlying mechanisms for the lower prevalence of AF among Asians, particularly in the presence of diabetes, deserve further study. Trial registration number ACTRN12610000374066. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://heart.bmj.com/cgi/content/short/105/11/842Test; http://dx.doi.org/10.1136/heartjnl-2018-314077Test |
| DOI: | 10.1136/heartjnl-2018-314077 |
| الإتاحة: | https://doi.org/10.1136/heartjnl-2018-314077Test http://heart.bmj.com/cgi/content/short/105/11/842Test |
| حقوق: | Copyright (C) 2019, BMJ Publishing Group Ltd |
| رقم الانضمام: | edsbas.3BEC5B7F |
| قاعدة البيانات: | BASE |
| DOI: | 10.1136/heartjnl-2018-314077 |
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