التفاصيل البيبلوغرافية
| العنوان: |
Impact of micronutrient supplementation during pregnancy on birth weight, duration of gestation, and perinatal mortality in rural western China: double blind cluster randomised controlled trial. |
| المؤلفون: |
Lingxia Zeng, Dibley, Michael J., Yue Cheng, Shaonong Dang, Suying Chang, Lingzhi Kong, Hong Yan |
| المصدر: |
BMJ: British Medical Journal (International Edition); 11/22/2008, Vol. 337 Issue 7680, p1211-1215, 5p, 1 Chart, 1 Graph |
| مصطلحات موضوعية: |
RANDOMIZED controlled trials, DIETARY supplements, INFANT health, MICRONUTRIENTS, FOLIC acid, PHYSIOLOGICAL effects of iron, NEONATAL mortality, MATERNAL health |
| مصطلحات جغرافية: |
CHINA |
| مستخلص: |
Objective To examine the impact of antenatal supplementation with multiple micronutrients or iron and folic acid compared with folic acid alone on birth weight, duration of gestation, and maternal haemoglobin concentration in the third trimester. Design Cluster randomised double blind controlled trial. Setting Two rural counties in north west China. Participants 5828 pregnant women and 4697 live births. Interventions Villages were randomised for all pregnant women to take either daily folie acid (control), iron with folie acid, or multiple micronutrients with a recommended allowance of 15 vitamins and minerals. Main outcome measures Birth weight, length, and head circumference measured within 72 hours after delivery. Neonatal survival assessed at the six week follow-up visit. Results Birth weight was 42 g (95% confidence interval 7 to 78 g) higher in the multiple micronutrients group compared with the folie acid group. Duration of gestation was 0. 23 weeks (0.10 to 0.36 weeks) longer in the iron-folic acid group and 0.19 weeks (0.06 to 0.32 weeks) longer in the multiple micronutrients group. Iron-folic acid was associated with a significantly reduced risk of early preterm delivery (<34 weeks) (relative risk 0.50, 0.27 to 0.94, P=0.031). There was a significant increase in haemoglobin concentration in both iroh-folic acid (5.0 g/l, 2.0 to 8.0 g/l, P=0.001) and multiple micronutrients (6.9 g/l, 4.1 to 9.6 g/l, P<0.001) groups compared with folie acid alone. In post hoc analyses there were no significant differences for perinatal mortality, but iron-folic acid was associated with a significantly reduced early neonatal mortality by 54% (relative risk 0.46, 0.21 to 0.98). Conclusion In rural populations in China antenatal ¦supplementation with iron-folic acid was associated with longer gestation and a reduction in early neonatal mortality compared with folie acid. Multiple micronutrients were associated with modestly increased birth weight compared with folic acid, but, despite this weight gain, there was no significant reduction in early neonatal mortality. Pregnant women in developing countries need sufficient doses of iron in nutrient supplements to maximise reductions in neonatal mortality. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
