نتائج البحث

1

Haploinsufficiency of the NF1 gene is associated with protection against diabetes

المؤلفون: Sirkku Peltonen, Roope A. Kallionpää, Juha Peltonen, Hannu Järveläinen, Jussi Leppävirta, Kari Auranen, Minna Pöyhönen

المساهمون: HUSLAB, Department of Medical and Clinical Genetics, Helsinki University Hospital Area, HUS Diagnostic Center, University of Helsinki, Minna Pöyhönen / Principal Investigator

المصدر: Journal of Medical Genetics

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, medicine.medical_specialty, congenital, hereditary, and neonatal diseases and abnormalities, Neurofibromatosis 1, genetic association studies, Type 2 diabetes, Haploinsufficiency, Cohort Studies, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Diabetes mellitus, Genes, Neurofibromatosis 1, Genetics, medicine, Humans, autoimmune diseases, Neurofibromatosis, Child, neoplasms, Genetics (clinical), Proportional Hazards Models, genetic predisposition to disease, Proportional hazards model, business.industry, Genotype-Phenotype Correlations, 1184 Genetics, developmental biology, physiology, Middle Aged, medicine.disease, Obesity, eye diseases, 3. Good health, nervous system diseases, 030104 developmental biology, Diabetes Mellitus, Type 2, 030220 oncology & carcinogenesis, Relative risk, Cohort, diabetes mellitus, Female, 3111 Biomedicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5edef69a046d2c1f2d3fe99aed52bf3bTest
http://europepmc.org/articles/PMC8142421Test

2

Interleukin 1 receptor antagonist (IL1RN) gene variants predict radiographic severity of knee osteoarthritis and risk of incident disease

المؤلفون: Svetlana Krasnokutsky, Michael Doherty, Mukundan Attur, Steven B. Abramson, Marc C. Hochberg, Jose U. Scher, Anthony G. Wilson, Joanne M. Jordan, Hua Zhou, Jenny T. Bencardino, Virginia B. Kraus, Michelle S. Yau, Braxton D. Mitchell, Johathan Samuels

المصدر: Annals of the Rheumatic Diseases

مصطلحات موضوعية: 0301 basic medicine, rheumatoid arthritis, Male, medicine.medical_specialty, Knee Joint, Immunology, Single-nucleotide polymorphism, Osteoarthritis, Gastroenterology, Polymorphism, Single Nucleotide, Risk Assessment, Severity of Illness Index, General Biochemistry, Genetics and Molecular Biology, Arthritis, Rheumatoid, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Risk Factors, Internal medicine, medicine, Immunology and Allergy, Humans, genetics, Interleukin 6, Aged, 030203 arthritis & rheumatology, biology, business.industry, Haplotype, Middle Aged, Osteoarthritis, Knee, medicine.disease, Radiography, Interleukin 1 Receptor Antagonist Protein, 030104 developmental biology, Interleukin 1 receptor antagonist, interleukins, Haplotypes, inflammation, Rheumatoid arthritis, Case-Control Studies, Cohort, biology.protein, Female, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b1025117141e30339953eb62f337b1Test
http://europepmc.org/articles/PMC7034355Test

3

Novel self-amplificatory loop between T cells and tenocytes as a driver of chronicity in tendon disease

المؤلفون: Lucy MacDonald, Umberto G. Fazzi, Neal L. Millar, Emma Garcia-Melchor, Iain B. McInnes, Lindsay A. N. Crowe, Shatakshi Sood, Giacomo Cafaro, Michael McLean, Moeed Akbar

المصدر: Annals of the Rheumatic Diseases

مصطلحات موضوعية: 0301 basic medicine, Stromal cell, medicine.medical_treatment, T cell, T-Lymphocytes, Immunology, General Biochemistry, Genetics and Molecular Biology, Collagen Type I, Proinflammatory cytokine, Tendons, 03 medical and health sciences, 0302 clinical medicine, Rheumatology, Immunology and Allergy, Medicine, T-lymphocyte subsets, Humans, tendinopathy, Cells, Cultured, 030203 arthritis & rheumatology, Cluster of differentiation, business.industry, Cell adhesion molecule, Cell biology, Miscellaneous, Tenocytes, Collagen, type I, alpha 1, 030104 developmental biology, Cytokine, medicine.anatomical_structure, inflammation, Culture Media, Conditioned, T cell migration, Cytokines, Collagen, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5128618648c036bfac629da1c1787562Test
http://europepmc.org/articles/PMC8292554Test

4

Real-world insights on preferred treatments for steroid-refractory immune checkpoint inhibitor-induced pneumonitis

المؤلفون: Gatti-Mays, Margaret, Gulley, James L

المصدر: Journal for ImmunoTherapy of Cancer, Vol 9, Iss 2 (2021)
Journal for Immunotherapy of Cancer

مصطلحات موضوعية: 0301 basic medicine, Oncology, Cancer Research, medicine.medical_specialty, Immune checkpoint inhibitors, medicine.medical_treatment, Immunology, programmed cell death 1 receptor, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, polycyclic compounds, medicine, Immunology and Allergy, Adverse effect, RC254-282, Pneumonitis, Pharmacology, business.industry, Incidence (epidemiology), Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Immunotherapy, Programmed Cell Death 1 Receptor, medicine.disease, Clinical trial, Editorial, 030104 developmental biology, 030220 oncology & carcinogenesis, Molecular Medicine, immunotherapy, Steroid refractory, business, guidelines as topic, hormones, hormone substitutes, and hormone antagonists

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c649cef396578a61a9a2f9dc3a664994Test
https://jitc.bmj.com/content/9/2/e002252.fullTest

5

Hepatitis B virus reactivation in cancer patients with positive Hepatitis B surface antigen undergoing PD-1 inhibition

المؤلفون: Yuxiang Ma, Ming Zhao, Yan Huang, Xiuyu Cai, Wenqi Jiang, Yixin Zhou, Hongyun Zhao, Chen Chen, Xiaoshi Zhang, Wenfeng Fang, Zuan Lin, Shaodong Hong, Li Zhang, Xuanye Zhang, Rui-Hua Xu, Yunpeng Yang, Bei Zhang

المصدر: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-10 (2019)
Journal for Immunotherapy of Cancer

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, HBsAg, medicine.medical_treatment, Programmed Cell Death 1 Receptor, medicine.disease_cause, Gastroenterology, B7-H1 Antigen, Antineoplastic Agents, Immunological, 0302 clinical medicine, Risk Factors, Neoplasms, PD-1, Immunology and Allergy, Cancer, biology, Checkpoint, virus diseases, Middle Aged, Reactivation, Hepatitis B, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, virology, Oncology, 030220 oncology & carcinogenesis, Molecular Medicine, Female, Immunotherapy, Safety, Antibody, liver disease, Research Article, Adult, PD-L1, medicine.medical_specialty, Hepatitis B virus, Immunology, Antiviral Agents, lcsh:RC254-282, Young Adult, 03 medical and health sciences, Internal medicine, Biomarkers, Tumor, medicine, Humans, Retrospective Studies, Pharmacology, Hepatitis, Chemotherapy, Hepatitis B Surface Antigens, business.industry, medicine.disease, digestive system diseases, 030104 developmental biology, Alanine transaminase, Commentary, biology.protein, Virus Activation, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea49583d5b5c254a92def2d9371d965Test
http://link.springer.com/article/10.1186/s40425-019-0808-5Test

6

Moving forward to address key unanswered questions on targeting PD-1/PD-L1 in cancer: limitations in preclinical models and the need to incorporate human modifying factors

المؤلفون: William J. Murphy, Catherine T. Le

المصدر: Journal for ImmunoTherapy of Cancer, Vol 7, Iss 1, Pp 1-5 (2019)
Journal for immunotherapy of cancer, vol 7, iss 1
Journal for Immunotherapy of Cancer

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Exhaustion, Cell, Programmed Cell Death 1 Receptor, Drug Evaluation, Preclinical, B7-H1 Antigen, Mice, Antineoplastic Agents, Immunological, 0302 clinical medicine, T-cell, Neoplasms, PD-1, Immunology and Allergy, 2.1 Biological and endogenous factors, Molecular Targeted Therapy, Aetiology, Cancer, biology, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Preclinical, medicine.anatomical_structure, Immunological, Oncology, 5.1 Pharmaceuticals, Priming, 030220 oncology & carcinogenesis, Disease Progression, Molecular Medicine, Development of treatments and therapeutic interventions, Signal Transduction, PD-L1, Cell type, T cell, Immunology, Antineoplastic Agents, lcsh:RC254-282, 03 medical and health sciences, Immune checkpoint inhibitors, Immune system, Rare Diseases, medicine, Animals, Humans, Pharmacology, business.industry, Animal, Xenograft Model Antitumor Assays, Immune checkpoint, Blockade, Disease Models, Animal, 030104 developmental biology, Orphan Drug, Good Health and Well Being, Preclinical modeling, Tumor progression, Disease Models, Commentary, biology.protein, Drug Evaluation, business, Neuroscience