Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases
| العنوان: | Molecular functions and clinical impact of thyroid hormone-triggered autophagy in liver-related diseases |
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| المؤلفون: | Kwang-Huei Lin, Chung-Ying Tsai, Ming-Ming Tsai, Hsiang-Cheng Chi, Chau-Ting Yeh |
| المصدر: | Journal of Biomedical Science, Vol 26, Iss 1, Pp 1-15 (2019) Journal of Biomedical Science |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Thyroid Hormones, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, lcsh:Medicine, Review, Mitochondrion, Biology, Mice, medicine, Autophagy, Animals, Homeostasis, Humans, Pharmacology (medical), Molecular Biology, Thyroid hormone receptor, Catabolism, Liver Neoplasms, Biochemistry (medical), Fatty liver, Thyroid, lcsh:R, non-alcoholic fatty liver disease, Cell Biology, General Medicine, hepatocellular carcinoma, medicine.disease, Rats, Thyroid hormone, medicine.anatomical_structure, Liver, Cancer research, Hormone |
| الوصف: | The liver is controlled by several metabolic hormones, including thyroid hormone, and characteristically displays high lysosomal activity as well as metabolic stress-triggered autophagy, which is stringently regulated by the levels of hormones and metabolites. Hepatic autophagy provides energy through catabolism of glucose, amino acids and free fatty acids for starved cells, facilitating the generation of new macromolecules and maintenance of the quantity and quality of cellular organelles, such as mitochondria. Dysregulation of autophagy and defective mitochondrial homeostasis contribute to hepatocyte injury and liver-related diseases, such as non-alcoholic fatty liver disease (NAFLD) and liver cancer. Thyroid hormones (TH) mediate several critical physiological processes including organ development, cell differentiation, metabolism and cell growth and maintenance. Accumulating evidence has revealed dysregulation of cellular TH activity as the underlying cause of several liver-related diseases, including alcoholic or non-alcoholic fatty liver disease and liver cancer. Data from epidemiologic, animal and clinical studies collectively support preventive functions of THs in liver-related diseases, highlighting the therapeutic potential of TH analogs. Elucidation of the molecular mechanisms and downstream targets of TH should thus facilitate the development of therapeutic strategies for a number of major public health issues. Here, we have reviewed recent studies focusing on the involvement of THs in hepatic homeostasis through induction of autophagy and their implications in liver-related diseases. Additionally, the potential underlying molecular pathways and therapeutic applications of THs in NAFLD and HCC are discussed. |
| اللغة: | English |
| تدمد: | 1423-0127 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9b16677d361b99396745fdfcbc35503Test http://link.springer.com/article/10.1186/s12929-019-0517-xTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....a9b16677d361b99396745fdfcbc35503 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230127 |
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