دورية أكاديمية
Brain metastasis from hepatocellular carcinoma associated with hepatitis B virus
| العنوان: | Brain metastasis from hepatocellular carcinoma associated with hepatitis B virus |
|---|---|
| المؤلفون: | FRATI, ALESSANDRO, SALVATI, Maurizio, GIARNIERI, Enrico, FRATI, Luigi, A. Santoro, G. Rocchi |
| المساهمون: | Frati, Alessandro, Salvati, Maurizio, Giarnieri, Enrico, A., Santoro, G., Rocchi, Frati, Luigi |
| بيانات النشر: | APSIT ASSOC PROM STUD IMMUNOL TUMOR |
| سنة النشر: | 2002 |
| المجموعة: | Sapienza Università di Roma: CINECA IRIS |
| مصطلحات موضوعية: | brain metastasi, hepatitis b viru, hepatocellular carcinoma, p16, p53, prb |
| الوصف: | Four cases of brain metastasis from hepatocellular carcinoma (HCC) associated with hepatitis B virus (HBV) are reported in an area not endemic for HBV infection. Two cases are unusual, since cerebral metastases were the only secondary localization. In these cases, no other sites of metastasization were detected either before or immediately following neurosurgical treatment. In all cases the expression of pRB, p53 and p16 tumor suppressor protein was studied with immunohistochemistry, both, in the primary and metastatic lesions. The pRB expression was as follows: in two cases, lack and moderate expression were observed both, in the primary and in the metastases; in the other two, pRB was not detected. In all cases p 53 expression was negative both, in the primary and the metastases. P16 expression was moderately expressed in three cases, both in the primary and the metastases. In one case it was absent. Hepatocarcinogenesis is a multistep process, in which several oncogenes and oncosuppressor genes are involved. In four unusual cases of spread to the brain, we evidenced that tumor suppressor protein expression of p16, p53, and particularly pRB (its aberrated expression is usually associated with metastasis) were altered. We also suggest that HBV and its X protein (HBX) might play an important role in such aggressive behavior of the neoplasia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/12385572; info:eu-repo/semantics/altIdentifier/wos/WOS:000178372800003; volume:21; issue:3; firstpage:321; lastpage:327; numberofpages:7; journal:JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH; http://hdl.handle.net/11573/254724Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0036738578; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000178372800003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest; http://www.scopus.com/inward/record.url?eid=2-s2.0-0036738578&partnerID=65&md5=1bb15717ecfec30a3bab6b19be52b3cfTest |
| الإتاحة: | http://hdl.handle.net/11573/254724Test http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=000178372800003&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=0c7ff228ccbaaa74236f48834a34396aTest http://www.scopus.com/inward/record.url?eid=2-s2.0-0036738578&partnerID=65&md5=1bb15717ecfec30a3bab6b19be52b3cfTest |
| رقم الانضمام: | edsbas.A5542D3D |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |